Results 201 to 210 of about 41,598 (256)

Diminazene Aceturate Ameliorates Hypertension‐Induced Cognitive Impairment by Disrupting the CCN1–Integrin αvβ6–TGF‐β Axis and Preserving Mitochondrial Integrity

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Hypertension drives cognitive decline through a previously unrecognized CCN1–integrin αvβ6–TGF‐β signaling axis that culminates in mitochondrial dysfunction and hippocampal neuronal injury. In this pathway, angiotensin II induces CCN1 upregulation, which activates αvβ6 integrin‐mediated release of latent TGF‐β, triggering SMAD2/3 phosphorylation and ...
Xufang Huo, Zhenyu Wu, Xinqian Zhou, Yuancheng Zhou, Jiming Liu, Hongbing Li, Yijiu Wu, You Huang, Guangling Feng, Xiaolin Hu, Qingfan Zeng   +10 more
wiley   +1 more source

Estrogen receptor β deficiency increases the susceptibility to ulcerative colitis by inducing mitochondrial fission and consequently accelerating senescence of colonic epithelial cells. [PDF]

Redox Biol
Guo Y, He Y, Zhu Y, Zhang W, Lin H, Zhao M, Zhang J, Bai Y, Wei Z, Xia Y, Dai Y.   +10 more
europepmc   +1 more source

Suppression of Rho-associated kinase 1 (ROCK1) promotes human hematopoietic stem cell expansion by attenuating mitochondrial fission. [PDF]

Leukemia
Wang X, Ramdas B, Kumar R, Zhang J, Kapur R, Kapur R.   +5 more
europepmc   +1 more source

Inhibition of DRP1-mediated Mitochondrial Fission and NRF2/HO-1/GPX4-mediated Ferroptosis by Mdivi-1 Protects Against Vascular Cognitive Impairment. [PDF]

Mol Neurobiol
Liu XM, Chen F, Cheng YJ, Wang DP.
europepmc   +1 more source

Mitochondrial fission process 1 protein: a comprehensive review of its core roles in mitochondrial dynamics, disease, and therapeutic targets. [PDF]

Front Cell Dev Biol
Ran Q, Gao C, Xiang C, He X, Zhang Y, Zhang Y, Chen H.   +6 more
europepmc   +1 more source

Mechanistic study of modulating mitochondrial fission and fusion to ameliorate neuropathic pain in mice. [PDF]

Sci Rep
Xie L, Cao J, Xu Y, Yang Q, Chang W, Song L, Sun Y.   +6 more
europepmc   +1 more source

Mitochondrial fission surveillance is coupled to Caenorhabditis elegans DNA and chromosome segregation integrity. [PDF]

PLoS Genet
Yang X, Wei R, Meng F, Liu D, Gong X, Ruvkun G, Wei W.   +6 more
europepmc   +1 more source

PHLPP1 regulates region-specific astroglial mitochondrial fission in response to oxidative stress in the male rat hippocampus. [PDF]

Sci Rep
Kim JE, Wang SH, Kang TC.
europepmc   +1 more source

Publisher Correction: Suppression of Rho-associated kinase 1 (ROCK1) promotes human hematopoietic stem cell expansion by attenuating mitochondrial fission. [PDF]

Leukemia
Wang X, Ramdas B, Kumar R, Zhang J, Kapur R.   +4 more
europepmc   +1 more source

Inhibition of mitochondrial fission protein Drp1 ameliorates skeletal myopathy in the D2-mdx model of Duchenne muscular dystrophy. [PDF]

Am J Physiol Cell Physiol
Rosen HG, Berger NJ, Hodge SN, Fujishiro A, Lourie J, Kapadia V, Duzz T, Linden MA, Jee E, Kim J, Kim Y, Zou K.   +11 more
europepmc   +1 more source