Results 231 to 240 of about 49,263 (303)

Mitochondrial Fission Regulator 1-Like Protein Protects the Heart from Ischemia/Reperfusion Injury via Dual Mitochondrial Mechanisms. [PDF]

Research (Wash D C)
Wei M, Song Y, Zhu M, Hu X, Ma S, Zhang S, Xie P, Guo R, Ma Z, Hou X, Zhang S, Fan J, Yang X, Saleem A, Lan F, Liu X, Cui M.   +16 more
europepmc   +1 more source

Raptor and Drp1 Function Synthetically to Control Hypoxic Death and the Mitochondrial Network in Caenorhabditis elegans

The FASEB Journal, Volume 40, Issue 13, 15 July 2026.
Hypoxia results in fragmented mitochondria. Whether this fragmentation promotes or prevents cell death is unresolved. Caenorhabditis elegans mutants defective in mitochondrial fission and fusion coupled with a hypoxia resistant Raptor mutant demonstrated that hypoxia‐induced mitochondrial fragmentation occurs without an intact fission machinery and ...
Julien Goldstick, Diego Compte, Chun‐Ling Sun, Alison E. Ritter, C. Michael Crowder   +4 more
wiley   +1 more source

Histone deacetylase 7 mediates lipopolysaccharide-inducible mitochondrial fission in macrophages. [PDF]

J Cell Sci
Abrol R, Afroz SF, Curson JEB, Raven KD, Das Gupta K, Gunther KS, Jones A, Reid RC, Xiong Z, Gunter JH, Engel JA, Engwerda CR, Blumenthal A, Fairlie DP, Parton RG, Zuryn S, Kapetanovic R, Ramnath D, Sweet MJ.   +18 more
europepmc   +1 more source

α7nAChR agonist GTS‐21 ameliorates sepsis‐induced acute kidney injury via MEF2/PGC‐1α/HO‐1 axis in mice

Clinical and Translational Medicine, Volume 16, Issue 7, July 2026.
This diagram illustrates opposing pathways regulating AKI (acute kidney injury). The left pathway shows LPS/TLR4 triggering mitochondrial damage (low MMP, Cyt C release, ROS) leading to apoptosis. The right pathway shows α7nAChR agonists activating MEF2 to upregulate PGC‐1α/HO‐1, promoting mitochondrial biogenesis and inhibiting injury, highlighting ...
Yu‐Jia Tang, Hui‐Ying Liu, Na‐Qi Li, Xin Zhang, Yi‐Lu Lin, Yan Zhang, Yao Li, Jia‐Le Deng, Pei‐Lin Yang, Qing‐Min Meng, Yi‐Jin Tang, Zi‐Yue Zhang, Si‐Han Guan, Kai Kang, Hong‐Liang Wang, Yang Gao   +15 more
wiley   +1 more source

Sirtuin 4 Knockout Aggravates Sepsis-Induced Acute Liver Injury by Enhancing Mitochondrial Fission and Mitophagy in Hepatocytes. [PDF]

Mediators Inflamm
Li N, Ma D, Luo S, He A, Chang S.
europepmc   +1 more source

Pyruvate Kinase M2 Mediates Apigenin‐Induced Energy Crisis and Apoptosis in Colon Cancer Cells

Food Frontiers, Volume 7, Issue 4, July 2026.
Apigenin, a dietary flavonoid with low toxicity, induces profound bioenergetic collapse in colon cancer cells by downregulating PKM2. This metabolic crisis, characterized by suppressed glycolysis and mitochondrial dysfunction, ultimately triggers robust apoptosis.
Ke Zhang, Xingtao Zhou, Xujie Wang, Mingyong Xie   +3 more
wiley   +1 more source

Advances in the Neurotoxic Mechanisms of Acrylamide and Multitarget Intervention Strategies of Natural Products

Food Frontiers, Volume 7, Issue 4, July 2026.
This review summarizes recent advances in acrylamide neurotoxicity mechanisms and highlights the multitarget neuroprotective effects of diverse natural products while also addressing current challenges and future translational research directions.
Wen Du, Yifan Zhao, Li Dong, Chen Ma, Xiaosong Hu, Daotong Li, Fang Chen, Yinghua Luo   +7 more
wiley   +1 more source

Histone lactylation leads to perioperative neurocognitive disorders by promoting the expression of Ralbp1 and inducing excessive mitochondrial fission in hippocampal neurons. [PDF]

Cell Mol Life Sci
Meng F, Cao S, Wu W, Zhang M, Jing Q, Xie Z, Sun X, Song J, Fei M, Chen Q, Gao X, Li C.   +11 more
europepmc   +1 more source

Ischemia–Reperfusion Injury: Molecular Mechanisms and Therapeutic Interventions

MedComm, Volume 7, Issue 7, July 2026.
Multiorgan ischemia–reperfusion injury begins with ischemia‐induced ATP depletion and ionic imbalance, followed by reperfusion‐triggered mitochondrial ROS/RNS bursts, regulated cell death, and DAMP release. Sterile inflammation converges on endothelial–immune–coagulation crosstalk, where NETs drive immunothrombosis, no‐reflow, and remote organ injury ...
Peng An, Yi An, Mengwei Chen, Longlong Wu, Rong Wang   +4 more
wiley   +1 more source

GCN5L1 Aggravates Postherpetic Neuralgia Through Regulating Microglial Mitochondrial Fission-Fusion Homeostasis. [PDF]

J Cell Mol Med
Li W, Cao X, Wang S, Jin X, Wang H.
europepmc   +1 more source