Results 231 to 240 of about 43,432 (263)

Mitochondrial fission and fusion

Biochemistry (Moscow), 2015
Mitochondria are key cellular organelles responsible for many different functions. The molecular biology of mitochondria is continuously subject to comprehensive studies. However, detailed mechanisms of mitochondrial biogenesis are still unclear. Fusion and fission are among the most enigmatic processes connected with mitochondria.
M V, Patrushev, I O, Mazunin, E N, Vinogradova, P A, Kamenski   +3 more
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Mitochondrial fusion and fission are required for proper mitochondrial function and cell proliferation in fission yeast

The FEBS Journal, 2021
Mitochondria form a branched tubular network in many types of cells, depending on a balance between mitochondrial fusion and fission. How mitochondrial fusion and fission are involved in regulating mitochondrial function and cell proliferation is not well understood.
Fenfen Dong, Mengdan Zhu, Fan Zheng, Chuanhai Fu   +3 more
openaire   +2 more sources

A Lethal Defect of Mitochondrial and Peroxisomal Fission

New England Journal of Medicine, 2007
We report on a newborn girl with microcephaly, abnormal brain development, optic atrophy and hypoplasia, persistent lactic acidemia, and a mildly elevated plasma concentration of very-long-chain fatty acids. We found a defect of the fission of both mitochondria and peroxisomes, as well as a heterozygous, dominant-negative mutation in the dynamin-like ...
Waterham, Hans R., Koster, Janet, van Roermund, Carlo W. T., Mooyer, Petra A. W., Wanders, Ronald J. A., Leonard, James V.   +5 more
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Reciprocal Regulation of Mitochondrial Fission and Fusion

Trends in Biochemical Sciences, 2020
The dynamic processes of mitochondrial fission and fusion are tightly regulated, determine mitochondrial shape, and influence mitochondrial functions. For example, fission and fusion mediate energy output, production of reactive oxygen species (ROS), and mitochondrial quality control.
Rasha Sabouny, Timothy E. Shutt
openaire   +2 more sources

Mitochondrial Fission Mediates Endothelial Inflammation

Hypertension, 2020
Endothelial inflammation and mitochondrial dysfunction have been implicated in cardiovascular diseases, yet, a unifying mechanism tying them together remains limited. Mitochondrial dysfunction is frequently associated with mitochondrial fission/fragmentation mediated by the GTPase Drp1 (dynamin-related protein 1).
Steven J, Forrester, Kyle J, Preston, Hannah A, Cooper, Michael J, Boyer, Kathleen M, Escoto, Anthony J, Poltronetti, Katherine J, Elliott, Ryohei, Kuroda, Masashi, Miyao, Hiromi, Sesaki, Tomoko, Akiyama, Yayoi, Kimura, Victor, Rizzo, Rosario, Scalia, Satoru, Eguchi   +14 more
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Mitochondrial fusion and fission in the control of apoptosis

Trends in Cell Biology, 2005
Mitochondrial outer membrane permeabilization (MOMP) determines the point-of-no-return of most if not all signal-transduction cascades leading to cell death. It has been postulated that the molecular mechanism leading to MOMP could depend on the activation of the mitochondrial fission machinery mediated by proteins from the dynamin superfamily. However,
Jean-Luc, Perfettini, Thomas, Roumier, Guido, Kroemer   +2 more
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Mitochondrial fission in apoptosis, neurodegeneration and aging

Current Opinion in Cell Biology, 2003
A decline in mitochondrial function is well recognized in neurodegenerative diseases and aging, and is thought to play a causal role in their biology. Unfortunately, the molecular basis underlying this detrimental loss in mitochondrial function remains mysterious. Interestingly, mitochondria undergo frequent fission and fusion.
Ella, Bossy-Wetzel, Mark J, Barsoum, Adam, Godzik, Robert, Schwarzenbacher, Stuart A, Lipton   +4 more
openaire   +2 more sources

Mitochondrial Dynamics — Mitochondrial Fission and Fusion in Human Diseases

New England Journal of Medicine, 2013
Mitochondria fuse and divide in response to cell demands and environment. Alterations in mitochondrial dynamics underlie various human diseases, including cancer and neurologic and cardiovascular diseases. Defining the alterations may identify potential therapeutic targets.
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Mitochondrial Fission and Fusion in Human Diseases

New England Journal of Medicine, 2014
no ...
Sanchis-Gomar, F, Derbré, Frédéric
openaire   +4 more sources

Mitochondrial and peroxisomal fission in cortical neurogenesis

The International Journal of Biochemistry & Cell Biology
The human brain is unique in its cellular diversity, intricate cytoarchitecture, function, and complex metabolic and bioenergetic demands, for which mitochondria and peroxisomes are essential. Mitochondria are multifunctional organelles that coordinate various signaling pathways central to neurogenesis.
Gabriella L. Robertson, Caroline Bodnya, Vivian Gama   +2 more
openaire   +2 more sources