Results 231 to 240 of about 57,770 (292)

Inhibition of Pathological Mitochondrial Fission in Retinal Pigment Epithelium Mitigates Choroidal Neovascularization. [PDF]

Invest Ophthalmol Vis Sci
Yasuda H, Nakamura S, Shirakawa A, Kuse Y, Shimazawa M.   +4 more
europepmc   +1 more source

LIN‐24 as a Molecular Switch: Dual Cytotoxic and Cytoprotective Roles of an Aerolysin‐Like Protein in C. elegans

Journal of Applied Toxicology, Volume 46, Issue 4, Page 1076-1082, April 2026.
ABSTRACT LIN‐24, an aerolysin‐like pore‐forming protein in Caenorhabditis elegans, exemplifies how ancient cytolytic mechanisms have evolved into regulated cellular processes. Initially identified for inducing nonapoptotic, engulfment‐dependent cell death in vulval precursor cells, LIN‐24 has emerged as a multifunctional regulator of metabolism, stress
Sharoen Yu Ming Lim
wiley   +1 more source

Mitochondrial Quality Control and Metabolic Reprogramming in Hepatocellular Carcinoma: Implications for Immunotherapy and Treatment Resistance. [PDF]

Cells
Zarlashat Y, Picca A.
europepmc   +1 more source

IL‐15 Links Muscle–Kidney Crosstalk to Preserving Podocyte Mitochondrial Fusion and Attenuating Diabetic Nephropathy

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 2, April 2026.
ABSTRACT Objectives High glucose induces mitochondrial dysfunction in podocytes, contributing to the development of diabetic nephropathy (DN). There is increasing evidence that muscles play a protective role by secreting myokines into the kidneys. Here, we investigated how skeletal muscle influences podocyte health via muscle–kidney crosstalk.
Yin Li, Jialing Rao, Weiyan Lai, Yuxiang Sun, Hongchun Lin, Jun Zhang, Zengchun Ye, Zhaoyong Hu, Hui Peng   +8 more
wiley   +1 more source

Mitochondria: the central hub linking exercise to enhanced cardiac function. [PDF]

Front Physiol
Cai J, Wang T, Li S.
europepmc   +1 more source

Clostridioides difficile‐Derived Extracellular Vesicles Induce Proinflammatory Responses in Macrophages

Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.
ABSTRACT Clostridioides difficile (CD) is a leading cause of antibiotic‐associated diarrhoea in both hospitalized and non‐hospitalized patients. This study explores the role of extracellular vesicles (EVs) derived from Clostridioides difficile strain 630 (CD630‐EVs), which released spherical EVs during in vitro culture, in modulating pro‐inflammatory ...
Fangfang Fan, Yu Zeng, Qianli Zhao, Tongxuan Su, Yining Shen, Wei Chen, Cen Jiang, Qi Ni, Yiyue Liu, Ru Fan, Danfeng Dong, Yibing Peng   +11 more
wiley   +1 more source

Unraveling the role of mitochondrial dysfunction in diabetic kidney disease: insights and interventions. [PDF]

Front Pharmacol
Fan Z, Luo P, Gao Y, Ma H, Fan J, Sanan S, Zhang P, Lu K, Xia H.   +8 more
europepmc   +1 more source

Cerebral Infarction: Epidemiology, Classification, Mechanisms, Diagnosis, and Management

MedComm, Volume 7, Issue 4, April 2026.
Within minutes after ischemia onset, deprivation of oxygen and glucose leads to rapid ATP depletion, resulting in failure of Na+/K+‐ATPase activity and membrane depolarization. This ionic imbalance promotes uncontrolled synaptic release of glutamate and excessive activation of postsynaptic NMDA and AMPA receptors.
Meibiao Zhang, Jianxun Hou, Jia Kuang, Lei Hao, Zhao Yang   +4 more
wiley   +1 more source

Hyperglycemia-Induced Endothelial Dysfunction: From Classical Pathogenetic Mechanisms to Emerging Insights into ACE2 Protective Action. [PDF]

Int J Mol Sci
Lodi G, Sergi D, Dipinto A, Bompan F, Secchiero P, Voltan R, Romani A.   +6 more
europepmc   +1 more source

Nanoceria Nanozyme Attenuates CoCl2‐Induced Oxidative Stress and Mitochondrial Dysfunction in H9c2 Cardiomyoblasts

Nano Select, Volume 7, Issue 4, April 2026.
This study shows that nanoceria protect H9c2 cardiomyoblasts from CoCl2‐induced chemical stress. Nanoceria reduces reactive oxygen species, preserves mitochondrial function, and regulates genes involved in antioxidant defense, intrinsic apoptosis, and inflammation. These findings highlight nanoceria's potential as a redox‐active nanozyme for protecting
Rukhsana Gul, Arwa Bazighifan, Mushtaq A. Dar, Shahid Nawaz, Assim A. Alfadda   +4 more
wiley   +1 more source