Results 11 to 20 of about 29,418 (143)

Mitochondrial fusion/fission dynamics in neurodegeneration and neuronal plasticity

Neurobiology of Disease, 2016
Mitochondria are dynamic organelles that continually move, fuse and divide. The dynamic balance of fusion and fission of mitochondria determines their morphology and allows their immediate adaptation to energetic needs, keeps mitochondria in good health ...
A.M. Bertholet, T. Delerue, A.M. Millet, M.F. Moulis, C. David, M. Daloyau, L. Arnauné-Pelloquin, N. Davezac, V. Mils, M.C. Miquel, M. Rojo, P. Belenguer   +11 more
doaj   +3 more sources

Targeting mitochondrial fusion and fission proteins for cardioprotection. [PDF]

J Cell Mol Med, 2020
AbstractNew treatments are needed to protect the myocardium against the detrimental effects of acute ischaemia/reperfusion (IR) injury following an acute myocardial infarction (AMI), in order to limit myocardial infarct (MI) size, preserve cardiac function and prevent the onset of heart failure (HF).
Hernandez-Resendiz S, Prunier F, Girao H, Dorn G, Hausenloy DJ, EU-CARDIOPROTECTION COST Action (CA16225).   +5 more
europepmc   +6 more sources

Mitochondrial fusion–fission dynamics and its involvement in colorectal cancer

Molecular Oncology
The incidence and mortality rates of colorectal cancer have elevated its status as a significant public health concern. Recent research has elucidated the crucial role of mitochondrial fusion–fission dynamics in the initiation and progression of ...
Zihong Wu, Chong Xiao, Fang Li, Wenbo Huang, Fengming You, Xueke Li   +5 more
doaj   +3 more sources

Mitochondrial fission and fusion [PDF]

Essays in Biochemistry, 2010
Mitochondria are highly dynamic cellular organelles, with the ability to change size, shape and position over the course of a few seconds. Many of these changes are related to the ability of mitochondria to undergo the highly co-ordinated processes of fission (division of a single organelle into two or more independent structures) or fusion (the ...
Iain, Scott, Richard J, Youle
openaire   +2 more sources

Mitochondrial fusion, fission, and mitochondrial toxicity [PDF]

Toxicology, 2017
Mitochondrial dynamics are regulated by two sets of opposed processes: mitochondrial fusion and fission, and mitochondrial biogenesis and degradation (including mitophagy), as well as processes such as intracellular transport. These processes maintain mitochondrial homeostasis, regulate mitochondrial form, volume and function, and are increasingly ...
Joel N, Meyer, Tess C, Leuthner, Anthony L, Luz   +2 more
openaire   +2 more sources

Mitochondrial Fission, Fusion, and Stress [PDF]

Science, 2012
Mitochondrial Dynamics Mitochondria—the powerhouses of the cell—are autonomous organelles with their own genomes. Within cells, mitochondria are remarkably dynamic, continually moving around the cytoplasm and undergoing fusion and fission reactions. Youle and van der Bliek (p. 1062 )
Richard J, Youle, Alexander M, van der Bliek   +1 more
openaire   +2 more sources

Mechanisms of Mitochondrial Fission and Fusion [PDF]

Cold Spring Harbor Perspectives in Biology, 2013
Mitochondria continually change shape through the combined actions of fission, fusion, and movement along cytoskeletal tracks. The lengths of mitochondria and the degree to which they form closed networks are determined by the balance between fission and fusion rates. These rates are influenced by metabolic and pathogenic conditions inside mitochondria
Alexander M, van der Bliek, Qinfang, Shen, Sumihiro, Kawajiri   +2 more
openaire   +2 more sources

Mitochondrial fission/fusion dynamics and apoptosis [PDF]

Mitochondrion, 2010
Mitochondria play an important role in the progression of apoptosis through the release of pro-apoptotic factors, such as cytochrome c, from the mitochondrial intermembrane space. During this process, mitochondrial networks are dramatically reorganised from long filamentous interconnected tubules into small punctate spheres.
MARTIN, SEAMUS, SHERIDAN, CLARE
openaire   +4 more sources

Dose-Dependent Response to the Environmental Pollutant Dichlorodipheniletylhene (DDE) in HepG2 Cells: Focus on Cell Viability and Mitochondrial Fusion/Fission Proteins

Toxics, 2021
Dichlorodiphenyldichloroethylene (DDE), the primary persistent metabolite of dichlorodiphenyltrichloroethane (DDT), has toxic effects on cells, but its dose-dependent impact on mitochondrial proteins involved in mitochondrial fusion and fission processes
Mario Alberto Burgos Aceves, Vincenzo Migliaccio, Marilena Lepretti, Gaetana Paolella, Ilaria Di Gregorio, Serena Penna, Caterina Faggio, Lillà Lionetti   +7 more
doaj   +1 more source

Enhanced mitochondrial fission suppresses signaling and metastasis in triple-negative breast cancer

Breast Cancer Research, 2020
Background Mitochondrial dynamics underlies malignant transformation, cancer progression, and response to treatment. Current research presents conflicting evidence for functions of mitochondrial fission and fusion in tumor progression.
Brock A. Humphries, Alyssa C. Cutter, Johanna M. Buschhaus, Yu-Chih Chen, Tonela Qyli, Dilrukshika S. W. Palagama, Samantha Eckley, Tanner H. Robison, Avinash Bevoor, Benjamin Chiang, Henry R. Haley, Saswat Sahoo, Phillip C. Spinosa, Dylan B. Neale, Jagadish Boppisetti, Debashis Sahoo, Pradipta Ghosh, Joerg Lahann, Brian D. Ross, Eusik Yoon, Kathryn E. Luker, Gary D. Luker   +21 more
doaj   +1 more source