Results 211 to 220 of about 53,117 (300)

Role of mitochondrial dysfunction in muscle wasting in cancer cachexia: a narrative review. [PDF]

J Transl Med
Su X, Wang S, Qu Y, Wang Y, Tian Z, Chao X, Li Z, Ma D.   +7 more
europepmc   +1 more source

Dynamic Changes of Mitochondrial Fusion and Fission in Brain Injury after Cardiac Arrest in Rats. [PDF]

Biomed Res Int, 2017
Li Y, Tang Q, Wang P, Qin J, Wu H, Lin J, Huang Z.   +6 more
europepmc   +1 more source

Oncolytic Probiotics with Molecular Pili for Solid Tumor Therapy

Advanced Science, Volume 13, Issue 19, 2 April 2026.
This study identifies Lactobacillus rhamnosus as an intrinsic oncolytic agent that triggers tumor metabolic collapse via calcium‐dependent ROS bursts. By chemically anchoring collagen‐targeting “molecular pili” to the bacterial surface, the engineered non‐transgenic probiotic (LR@MP) achieves targeted colonization and potent solid tumor suppression ...
Haodong Ge, Chengsheng Ding, Xiao Yang, Si Gao, Changjie Yang, Yuchen Hou, Hongye Wang, Linke Bian, Hao Zhong, Yifan Qu, Luyang Zhang, Junjun Ma, Zhengwei Cai, Wenguo Cui, Minhua Zheng   +14 more
wiley   +1 more source

Mitochondrial quality control: a new mechanism for antiviral therapy. [PDF]

Front Immunol
Duan X, Lan W, Liu R, Zhang P, Chen S, Zhang Y, Zhang L, Li H, Liu S.   +8 more
europepmc   +1 more source

PIK3CA Mutations Downregulate PPT1 to Promote Adipogenesis by Suppressing P300 Depalmitoylation and Phase Separation

Advanced Science, Volume 13, Issue 19, 2 April 2026.
This study demonstrates that somatic PIK3CA mutations suppress PPT1 expression via activation of the PI3K–AKT–c‐JUN axis. This reduction in PPT1 weakens its interaction with P300, thereby increasing palmitoylation at C1176 of P300 and protecting P300 from lysosomal degradation.
Hongrui Chen, Zening Huang, Rui Chang, Wei Gao, Yajing Qiu, Bin Sun, Chen Hua, Xiaoxi Lin   +7 more
wiley   +1 more source

Investigating the Antidepressant Mechanism of Acupuncture with a Focus on Mitochondrial Homeostasis. [PDF]

Int J Gen Med
Wei Y, Ma Z, Xu N, He Y, Cao M, Wang L.
europepmc   +1 more source

Lactylation Reprogramming in the Bone Infection Microenvironment Identifies PGK1 K361 as a Potential Therapeutic Target for Osteogenic Dysfunction

Advanced Science, Volume 13, Issue 19, 2 April 2026.
Staphylococcus aureus (S. aureus) infection creates a high‐lactate microenvironment, promoting p300‐mediated lactylation of PGK1 at lysine 361 (K361). Lactylated PGK1 translocates to the mitochondrial outer membrane and interacts with VDAC3. This interaction triggers FtMt downregulation, iron accumulation, and excessive PINK1/Parkin‐mediated mitophagy,
Han‐jun Qin, Si‐ying He, Ting‐hui Xiao, Da‐mao Dai, Xin‐jia Hu, Nan Jiang   +5 more
wiley   +1 more source

Targeting NME3 to Restore Mitochondrial Fission-Fusion Balance Defines a Novel Disease-Modifying Strategy for Parkinson's Disease. [PDF]

CNS Neurosci Ther
Qiao C, Hu XQ, Xu SH, Yao MF, Liu JP, Cao L.   +5 more
europepmc   +1 more source

In Vitro Antimicrobial Activity and In Vivo Intestinal Barrier Regulation by Commiphora leptophloeos Bark Extract in 5‐Fluorouracil–Induced Mucositis

Chemistry &Biodiversity, Volume 23, Issue 4, April 2026.
ABSTRACT This study evaluated the phytochemical composition, antimicrobial activity, and in vivo protective effects of the hydroethanolic extract from Commiphora leptophloeos stem bark (HECL) against 5‐fluorouracil (5‐FU)‐induced intestinal mucositis. Despite the extensive traditional use of C.
Stphannie Jamyla de Araújo Barbosa, Renato Dantas‐Medeiros, Susana Barbosa Ribeiro, Amanda Silveira da Silva, Lucas Vinicius Souza de Carvalho, Rafaela Torres Dantas da Silva, Gerlane Coelho Bernardo Guerra, Raimundo Fernandes de Araújo Júnior, Nizyara Costa da Silva, Raphael Victor Silva Andrade, Gabrielle Marques de Paiva, Silvana Maria Zucolotto, Rafaela Alcindo Silva de Sousa Fé, Maria Laura de Souza Lima, Raphaël Grougnet, Sergio Ortiz, Ana Caroline Zanatta, Aurigena Antunes de Araújo   +17 more
wiley   +1 more source

Mechanisms and therapeutic potential of mitochondrial-targeted therapies in bone repair. [PDF]

Ann Med
Xu N, Ma W, Liu G, Yang F.
europepmc   +1 more source