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Mitochondrial Fission and Fusion in Human Diseases

New England Journal of Medicine, 2014
no ...
Sanchis-Gomar, F, Derbré, Frédéric
openaire   +4 more sources

Intersection between Mitochondrial Permeability Pores and Mitochondrial Fusion/Fission

Neurochemical Research, 2007
The goal of this review is to highlight recent developments in the field of mitochondrial membrane processes, which provide new insights into the relation between mitochondrial fission/fusion events and the mitochondrial permeability transition (MPT).
Irina G, Gazaryan, Abraham M, Brown
openaire   +2 more sources

Mitochondrial fusion and fission are required for proper mitochondrial function and cell proliferation in fission yeast

The FEBS Journal, 2021
Mitochondria form a branched tubular network in many types of cells, depending on a balance between mitochondrial fusion and fission. How mitochondrial fusion and fission are involved in regulating mitochondrial function and cell proliferation is not well understood.
Fenfen Dong   +3 more
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Mitochondrial fission and fusion machineries

2004
Mitochondria are dynamic organelles, often fusing and dividing in response to changes in the cellular environment, during cell division and differentiation and under many other circumstances that affect mitochondrial function. Mitochondrial division is also an integral part of the apoptotic pathway in mammalian cells.
Lorena Griparic   +2 more
openaire   +1 more source

Mitochondrial fusion and fission in the control of apoptosis

Trends in Cell Biology, 2005
Mitochondrial outer membrane permeabilization (MOMP) determines the point-of-no-return of most if not all signal-transduction cascades leading to cell death. It has been postulated that the molecular mechanism leading to MOMP could depend on the activation of the mitochondrial fission machinery mediated by proteins from the dynamin superfamily. However,
Jean-Luc, Perfettini   +2 more
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Mitochondrial Dynamics — Mitochondrial Fission and Fusion in Human Diseases

New England Journal of Medicine, 2013
Mitochondria fuse and divide in response to cell demands and environment. Alterations in mitochondrial dynamics underlie various human diseases, including cancer and neurologic and cardiovascular diseases. Defining the alterations may identify potential therapeutic targets.
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Bcl-2 family proteins and mitochondrial fission/fusion dynamics

Cellular and Molecular Life Sciences, 2010
Mitochondria are dynamic organelles and can undergo regulated fission/fragmentation to produce smaller organelles or, alternatively, can undergo fusion to produce tubular or net-like mitochondrial structures. Although some of the molecules that control mitochondrial fission and fusion are known, new molecules and pathways that control this process ...
Arnaud, Autret, Seamus J, Martin
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Mitochondrial fission and fusion in neurodegenerative diseases:Ca2+ signalling

Molecular and Cellular Neuroscience
Neurodegenerative diseases (NDs) are a group of disorders characterized by the progressive loss of neuronal structure and function. The pathogenesis is intricate and involves a network of interactions among multiple causes and systems. Mitochondria and Ca2+ signaling have long been considered to play important roles in the development of various NDs ...
Xuan, Liu   +4 more
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Mitochondrial fusion and fission in cell life and death

Nature Reviews Molecular Cell Biology, 2010
Mitochondria are dynamic organelles that constantly fuse and divide. These processes (collectively termed mitochondrial dynamics) are important for mitochondrial inheritance and for the maintenance of mitochondrial functions. The core components of the evolutionarily conserved fusion and fission machineries have now been identified, and mechanistic ...
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Mitochondrial fission and fusion and their roles in the heart

Journal of Molecular Medicine, 2010
Mitochondria are dynamic organelles that usually exist in extensive and interconnected networks that undergo constant remodeling through fission and fusion. These processes are governed by distinct sets of proteins whose mechanism and regulation we are only beginning to fully understand.
Lesley A, Kane, Richard J, Youle
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