Results 21 to 30 of about 29,418 (143)
TRAP1 controls mitochondrial fusion/fission balance through Drp1 and Mff expression. [PDF]
PLoS ONE, 2012 Mitochondria are dynamic organelles that change in response to extracellular stimuli. These changes are essential for normal mitochondrial/cellular function and are controlled by a tight balance between two antagonistic pathways that promote fusion and ...
Hironori Takamura +8 more
doaj +1 more source
An ER phospholipid hydrolase drives ER-associated mitochondrial constriction for fission and fusion
eLife, 2022 Mitochondria are dynamic organelles that undergo cycles of fission and fusion at a unified platform defined by endoplasmic reticulum (ER)-mitochondria membrane contact sites (MCSs). These MCSs or nodes co-localize fission and fusion machinery. We set out
Tricia T Nguyen, Gia K Voeltz
doaj +1 more source
Neurobiology of Disease, 2011 Changes in dynamic properties of mitochondria are increasingly implicated in neurodegenerative diseases, particularly Parkinson's disease (PD). Static changes in mitochondrial morphology, often under acutely toxic conditions, are commonly utilized as ...
Beth Arnold +3 more
doaj +1 more source
New therapeutic directions in type II diabetes and its complications: mitochondrial dynamics
Frontiers in Endocrinology, 2023 As important organelles of energetic and metabolism, changes in the dynamic state of mitochondria affect the homeostasis of cellular metabolism. Mitochondrial dynamics include mitochondrial fusion and mitochondrial fission.
Shengnan Wang +7 more
doaj +1 more source
Mitochondrial fission/fusion and cardiomyopathy [PDF]
Current Opinion in Genetics & Development, 2016 Mitochondria are highly abundant in and essential to the beat-to-beat contractile performance of hearts. However, relatively few cardiac diseases have been attributed to primary mitochondrial dysfunction. The paucity of evidence for 'primary mitochondrial cardiac diseases' may be because such an entity does not exist.
openaire +2 more sources
Role of GTPase-Dependent Mitochondrial Dynamins in Heart Diseases
Frontiers in Cardiovascular Medicine, 2021 Heart function maintenance requires a large amount of energy, which is supplied by the mitochondria. In addition to providing energy to cardiomyocytes, mitochondria also play an important role in maintaining cell function and homeostasis.
Jiangen Liu +3 more
doaj +1 more source
Plant mitochondrial fission and fusion
Plant Biotechnology, 2005 Single plant cells have hundreds of mitochondria that move around and change their shape through the processes of fission and fusion. The Arabidopsis genome has genes for two dynamin-related proteins, DRP3A and DRP3B, that are similar to genes involved in mitochondrial fission in yeasts. DRP3A and DRP3B were localized to mitochondrial constricted sites
Shin-Ichi, Arimura, Nobuhiro, Tsutsumi
openaire +3 more sources
Deceleration of fusion-fission cycles improves mitochondrial quality control during aging. [PDF]
PLoS Computational Biology, 2012 Mitochondrial dynamics and mitophagy play a key role in ensuring mitochondrial quality control. Impairment thereof was proposed to be causative to neurodegenerative diseases, diabetes, and cancer.
Marc Thilo Figge +3 more
doaj +1 more source
Emerging functions of mammalian mitochondrial fusion and fission [PDF]
Human Molecular Genetics, 2005 Mitochondria provide a myriad of services to the cell, including energy production, calcium buffering and regulation of apoptosis. How these diverse functions are coordinated among the hundreds of mitochondria in a given cell is largely unknown, but is probably dependent on the dynamic nature of mitochondria.
Hsiuchen, Chen, David C, Chan
openaire +2 more sources
Mitochondrial Fusion and Fission in Mammals [PDF]
Annual Review of Cell and Developmental Biology, 2006 Eukaryotic cells maintain the overall shape of their mitochondria by balancing the opposing processes of mitochondrial fusion and fission. Unbalanced fission leads to mitochondrial fragmentation, and unbalanced fusion leads to mitochondrial elongation.
openaire +3 more sources