Results 31 to 40 of about 29,418 (143)

Mitochondrial Fission and Fusion in Tumor Progression to Metastasis

Frontiers in Cell and Developmental Biology, 2022
Mitochondria are highly dynamic organelles which can change their shape, via processes termed fission and fusion, in order to adapt to different environmental and developmental contexts. Due to the importance of these processes in maintaining a physiologically healthy pool of mitochondria, aberrant cycles of fission/fusion are often seen in ...
Dillon P. Boulton, Dillon P. Boulton, M. Cecilia Caino   +2 more
openaire   +3 more sources

BDE-47 induces nephrotoxicity through ROS-dependent pathways of mitochondrial dynamics in PK15 cells

Ecotoxicology and Environmental Safety, 2021
2,2’,4,4’-tetrabromodiphenyl ether (BDE-47)-induced nephrotoxicity is closely associated with oxidative stresses and mitochondrial abnormalities.
Shiyao Sun, Zhihui Zhao, Qinxiong Rao, XiaoMin Li, Zheng Ruan, Junhua Yang   +5 more
doaj   +1 more source

Drosophila phosphatidylinositol-4 kinase fwd promotes mitochondrial fission and can suppress Pink1/parkin phenotypes.

PLoS Genetics, 2020
Balanced mitochondrial fission and fusion play an important role in shaping and distributing mitochondria, as well as contributing to mitochondrial homeostasis and adaptation to stress.
Ana Terriente-Felix, Emma L Wilson, Alexander J Whitworth   +2 more
doaj   +1 more source

Hypobaric Hypoxia Imbalances Mitochondrial Dynamics in Rat Brain Hippocampus

Neurology Research International, 2015
Brain is predominantly susceptible to oxidative stress and mitochondrial dysfunction during hypobaric hypoxia, and therefore undergoes neurodegeneration due to energy crisis.
Khushbu Jain, Dipti Prasad, Shashi Bala Singh, Ekta Kohli   +3 more
doaj   +1 more source

Camptothecin, triptolide, and apoptosis inducer kit have differential effects on mitochondria in colorectal carcinoma cells

FEBS Open Bio, 2022
Mitochondrial fission and fusion are required for cell survival, and several studies have shown an imbalance between fission and fusion in cancer. High levels of mitochondrial fusion are observed in drug‐resistant tumor cells, whereas mitochondrial ...
Veronika Liskova, Marek Kajsik, Barbora Chovancova, Ladislav Roller, Olga Krizanova   +4 more
doaj   +1 more source

Attenuation of PM2.5-induced alveolar epithelial cells and lung injury through regulation of mitochondrial fission and fusion

Particle and Fibre Toxicology, 2023
Background Exposure to particulate matter (PM) with an aerodynamic diameter less than 2.5 μm (PM2.5) is a risk factor for developing pulmonary diseases and the worsening of ongoing disease.
Qi Liu, Jiali Weng, Chenfei Li, Yi Feng, Meiqin Xie, Xiaohui Wang, Qing Chang, Mengnan Li, Kian Fan Chung, Ian M Adcock, Yan Huang, Hai Zhang, Feng Li   +12 more
doaj   +1 more source

Super-Resolution Quantification of T2DM-Induced Mitochondrial Morphology Changes and Their Implications in Pharmacodynamics of Metformin and Sorafenib

Frontiers in Pharmacology, 2022
Mitochondria, as the powerhouse of cells, are involved in various processes of cellular homeostasis, especially energy metabolism. The morphology of mitochondria is a critical indicator for their functions, referring to mitochondrial fusion and fission ...
Yang Du, Ya-Juan Zhu, Bo Zeng, Xiao-Li Mu, Ji-Yan Liu   +4 more
doaj   +1 more source

Role of mitochondrial fission and fusion in cardiomyocyte contractility [PDF]

International Journal of Cardiology, 2015
Mitochondria constitute 30% of cell volume and are engaged in two dynamic processes called fission and fusion, regulated by Drp-1 (dynamin related protein) and mitofusin 2 (Mfn2). Previously, we showed that Drp-1 inhibition attenuates cardiovascular dysfunction following pressure overload in aortic banding model and myocardial infarction.
S, Givvimani, S B, Pushpakumar, N, Metreveli, S, Veeranki, S, Kundu, S C, Tyagi   +5 more
openaire   +2 more sources

Microtubules are Essential for Mitochondrial Dynamics-Fission, Fusion, and Motility- in Dictyostelium discoideum.

Frontiers in Cell and Developmental Biology, 2016
Mitochondrial function is dependent upon mitochondrial structure which is in turn dependent upon mitochondrial dynamics, including fission, fusion, and motility.
Laken C. Woods, Gregory W. Berbusse, Kari eNaylor   +2 more
doaj   +1 more source

Mitochondrial fission and fusion in Dictyostelium discoideum: a search for proteins involved in membrane dynamics

BMC Research Notes, 2012
Background Mitochondrial morphology is maintained by two distinct membrane events -fission and fusion. Altering these conserved processes can disrupt mitochondrial morphology and distribution, thereby disrupting the organelle’s functionality and impeding
Schimmel Brixey G, Berbusse Gregory W, Naylor Kari   +2 more
doaj   +1 more source