Results 101 to 110 of about 13,532 (177)

Mitofusin-mediated contacts between mitochondria and peroxisomes regulate mitochondrial fusion.

PLoS Biology
Mitofusins are large GTPases that trigger fusion of mitochondrial outer membranes. Similarly to the human mitofusin Mfn2, which also tethers mitochondria to the endoplasmic reticulum (ER), the yeast mitofusin Fzo1 stimulates contacts between Peroxisomes ...
Cynthia Alsayyah, Manish K Singh, Maria Angeles Morcillo-Parra, Laetitia Cavellini, Nadav Shai, Christine Schmitt, Maya Schuldiner, Einat Zalckvar, Adeline Mallet, Naïma Belgareh-Touzé, Christophe Zimmer, Mickaël M Cohen   +11 more
doaj   +1 more source

Small Molecule Activators of Mitochondrial Fusion Prevent Congenital Heart Defects Induced by Maternal Diabetes

JACC: Basic to Translational Science
Summary: Most congenital heart defect (CHD) cases are attributed to nongenetic factors; however, the mechanisms underlying nongenetic factor–induced CHDs are elusive.
Guanglei Wang, PhD, Wenhui Lu, PhD, Wei-Bin Shen, PhD, Mariusz Karbowski, PhD, Sunjay Kaushal, MD, PhD, Peixin Yang, PhD   +5 more
doaj   +1 more source

Mitofusin 2 in Mature Adipocytes Controls Adiposity and Body Weight

, 2019
Summary: We found that exposure of adult animals to calorie-dense foods rapidly abolished expression of mitofusin 2 (Mfn2), a gene promoting mitochondrial fusion and mitochondrion-endoplasmic reticulum interactions, in white and brown fat.
Giacomo Mancini, Tamas L. Horvath, Kevin Pirruccio, Xiaoyong Yang, Matthias Blücher, Matthew Rodeheffer   +5 more
core   +1 more source

Mitochondrial dysfunction in cardiovascular disease: investigating therapeutic approaches to enhance patient outcomes

MGM Journal of Medical Sciences
Mitochondria, the energy-generating organelles, undergo continuous biosynthesis, fission, fusion, and degradation cycles to maintain structural integrity.
Omar Elsaka
doaj   +1 more source

Role of mitofusin 2 and mitochondrial dynamics in osteoclast differentiation and function

Os osteoclastos são macrófagos tecido-específicos com a função de reabsorção óssea. Por serem células gigantes e multinucleadas, os osteoclastos necessitam, desde a sua formação, passando pela adesão e movimentação na superfície óssea e finalmente pela ...
Venturini, Lucas Gabriel Rodrigues
core   +1 more source

Baicalin inhibits infectious bronchitis virus replication via MAVS-dependent interferon-β upregulation and mitochondrial function preservation

Scientific Reports
The inhibitory effect of baicalin on infectious bronchitis virus (IBV) replication is closely related to expression of the mitochondrial antiviral signaling protein (MAVS) in chicken embryonic kidney (CEK) cells.
Jiongjie He, Huilin Guo, Ling Wang, Shengyi Wang   +3 more
doaj   +1 more source

The role of ultrasound and mitofusin-2 levels to predict pregnancy outcomes in patients with severe preeclampsia: a case-control study

OBJECTIVE: The aim of this study was to evaluate mitofusin-2 levels and fetal Doppler ultrasonography effects in patients with severe preeclampsia. METHODS: This single-center case-control study was conducted in the gynecology service of the university ...
Uçkan, Kazım, Eyisoy, Ömer Gökhan, Çeleğen, İzzet, Özgökçe, Çağdaş, Akbay, Halil İbrahim, Başkiran, Yusuf   +5 more
core   +1 more source

Neuromuscular Dysfunction and Charcot-Marie-Tooth Disease Reversal in Mfn2 T105M Knock-In Rats. [PDF]

Int J Mol Sci
Weigele J, Franco A, Dorn GW.
europepmc   +1 more source

Correction: Bendless is essential for PINK1-Park mediated Mitofusin degradation under mitochondrial stress caused by loss of LRPPRC. [PDF]

PLoS Genet
Cheramangalam RN, Anand T, Pandey P, Balasubramanian D, Varghese R, Singhal N, Jaiswal SN, Jaiswal M.   +7 more
europepmc   +1 more source

Zebrafish mitofusin-2 knockdown: a new model for CMT2A neuropathy?

, 2009
Mitofusin 2 (MFN2) is a large dynamin-like GTPase protein, located in the outer membrane of mitochondria and at the surface of the endoplasmic reticulum.
VETTORI, ANDREA, ARGENTON, FRANCESCO, TISO, NATASCIA, MOSTACCIUOLO, MARIA LUISA, VAZZA, GIOVANNI, POLO G, BERGAMIN, GIORGIA, MORO, ENRICO   +7 more
core