Results 111 to 120 of about 17,983 (257)

MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin

eLife, 2014
Parkinson's disease (PD) genes PINK1 and parkin act in a common pathway that regulates mitochondrial integrity and quality. Identifying new suppressors of the pathway is important for finding new therapeutic strategies.
Jina Yun, Rajat Puri, Huan Yang, Michael A Lizzio, Chunlai Wu, Zu-Hang Sheng, Ming Guo   +6 more
doaj   +1 more source

Implications of mitochondrial dynamics on neurodegeneration and on hypothalamic dysfunction [PDF]

, 2015
Mitochondrial dynamics is a term that encompasses the movement of mitochondria along the cytoskeleton, regulation of their architecture, and connectivity mediated by tethering and fusion/fission.
Antonio Zorzano, Marc Claret
core   +2 more sources

Discovery of PHB1 as a Novel Candidate Gene in Dominant Optic Atrophy

Clinical Genetics, EarlyView.
A heterozygous PHB1 missense variant (p.Ser147Phe) segregates with autosomal dominant optic atrophy in a multi‐generation family. Structural and cellular analyses suggest altered mitochondrial dynamics, identifying PHB1 as a novel candidate gene for hereditary optic neuropathy. ABSTRACT Hereditary optic neuropathies comprise a genetically heterogeneous
Marija Volk, Aleš Maver, Martina Jarc Vidmar, Nuša Trošt, Tanja Višnjar, Ana Fakin, Lea Kovač, Maja Šuštar Habjan, Lucija Malinar, Sanja Petrović Pajić, Urška Dragin Jerman, Rok Romih, Marko Hawlina, Borut Peterlin   +13 more
wiley   +1 more source

Role of Mitofusin 2 in the Renal Stress Response

PLoS ONE, 2012
The role of mitofusin 2 (MFN2), a key regulator of mitochondrial morphology and function in the renal stress response is unknown. To assess its role, the MFN2 floxed gene was conditionally deleted in the kidney of mice (MFN2 cKO) by Pax2 promoter driven Cre expression (Pax2Cre).
Jonathan M Gall, Zhiyong Wang, Marc Liesa, Anthony Molina, Andrea Havasi, John H Schwartz, Orian Shirihai, Steven C Borkan, Ramon G B Bonegio   +8 more
openaire   +4 more sources

Fibrotic scar formation after cerebral ischemic stroke: Targeting the Sonic hedgehog signaling pathway for scar reduction

Neural Regeneration Research
Recent studies have shown that fibrotic scar formation following cerebral ischemic injury has varying effects depending on the microenvironment. However, little is known about how fibrosis is induced and regulated after cerebral ischemic injury.
Jun Wen, Hao Tang, Mingfen Tian, Ling Wang, Qinghuan Yang, Yong Zhao, Xuemei Li, Yu Ren, Jiani Wang, Li Zhou, Yongjun Tan, Haiyun Wu, Xinrui Cai, Yilin Wang, Hui Cao, Jianfeng Xu, Qin Yang   +16 more
doaj   +1 more source

Inhibition of cAMP/PKA Pathway Protects Optic Nerve Head Astrocytes against Oxidative Stress by Akt/Bax Phosphorylation-Mediated Mfn1/2 Oligomerization. [PDF]

, 2019
Glaucoma is characterized by a progressive optic nerve degeneration and retinal ganglion cell loss, but the underlying biological basis for the accompanying neurodegeneration is not known.
Ahn, Sangphil, Edwards, Genea, Ju, Won-Kyu, Kim, Keun-Young, Park, Tae Lim, Shim, Myoung Sup, Weinreb, Robert N   +6 more
core   +1 more source

A membrane-inserted structural model of the yeast mitofusin Fzo1 [PDF]

, 2017
Mitofusins are large transmembrane GTPases of the dynamin-related protein family, and are required for the tethering and fusion of mitochondrial outer membranes.
A Fiser, A Franco, A Lupas, A Sali, A Santel, AA Polyansky, AB Knott, AM Bertholet, B Brosig, B Hess, B Westermann, C Notredame, C Volland, CR Søndergaard, D Naon, D Rapaport, DT Jones, DT Jones, E Boutet, EE Griffin, EF Pettersen, EG Hutchinson, F Anton, F Anton, F Armougom, F Sievers, G Pollastri, GJ Hermann, H Kishida, H Sesaki, H Viklund, HH Low, HH Low, HJC Berendsen, HM Berman, IM Wallace, JM Mason, JS Chappie, K Hofmann, K Labbé, L Cavellini, L Yan, L Yan, M Escobar-Henriques, M Rojo, M-P Durrieu, M-Y Shen, MA Lemmon, MA Lomize, MM Cohen, MS Longtine, N Ishihara, NJ Gleason, O Daumke, OM Brito de, P Hubert, R Filadi, R Yan, RA Laskowski, RA Laskowski, RFS Walters, RL Dunbrack, S Fritz, S Jo, S Lee, S-Q Zhang, SF Altschul, T Darden, T Koshiba, T Nugent, T Shutt, TJ Dolinsky, VB Chen, W Kabsch, WL Jorgensen, X Bian, X Daura, Y Qi, Y-L Cao   +78 more
core   +4 more sources

ER proteostasis meets mitochondrial function: contact sites as hubs of communication and therapeutic targets

The FEBS Journal, EarlyView.
Proteostasis ensures proper protein folding, modification, and degradation, while its impairment triggers ER stress. Chronic ER stress and maladaptive UPR via the CHOP–ERO1 axis remodel ERMCs, altering calcium signaling and mitochondrial metabolism.
Giorgia Maria Renna, Alessandro Cherubini, Ersilia Varone, Serena Germani, Alice Marrazza, Ester Zito   +5 more
wiley   +1 more source

Structural analysis of a trimeric assembly of the mitochondrial dynamin-like GTPase Mgm1. [PDF]

, 2020
The fusion of inner mitochondrial membranes requires dynamin-like GTPases, Mgm1 in yeast and OPA1 in mammals, but how they mediate membrane fusion is poorly understood.
Hu, Junjie, Li, Lei, Lou, Zhiyong, Nunnari, Jodi, Qi, Yuanbo, Rao, Zihe, Ricketson, Derek, Sarsam, Reta, Subramanian, Kelly, Wong, Melissa, Wu, Lijie, Yan, Liming, Yu, Caiting, Zhao, Jinghua   +13 more
core  

Signalling Mechanisms Underlying Doxorubicin and Nox2 NADPH Oxidase-Induced Cardiomyopathy: Involvement of Mitofusin-2 [PDF]

, 2017
BACKGROUND AND PURPOSE: The anthracycline doxorubicin (DOX), although successful as a first-line cancer treatment, induces cardiotoxicity linked with increased production of myocardial reactive oxygen species (ROS), with Nox2 NADPH oxidase-derived ...
Dunne, Philip D, Edgar, Kevin S, Grieve, David J, Kearney, Anna M, McDermott, Barbara J, McLaughlin, Declan, O'Neill, Karla M, Zhao, Youyou   +7 more
core   +1 more source