Results 71 to 80 of about 17,646 (230)

Mitochondrial Dynamics at the Interface of Immune Cell Metabolism and Function

, 2018
Immune cell differentiation and function are crucially dependent on specific metabolic programs dictated by mitochondria, including the generation of ATP from the oxidation of nutrients and supplying precursors for the synthesis of macromolecules and ...
Pearce, E., Rambold, A.
core   +1 more source

αSynuclein control of mitochondrial homeostasis in human-derived neurons is disrupted by mutations associated with Parkinson’s disease [PDF]

, 2017
The etiology of Parkinson’s disease (PD) converges on a common pathogenic pathway of mitochondrial defects in which α-Synuclein (αSyn) is thought to play a role.
Alloatti, Matías, Cromberg, Lucas Eneas, Dimopoulos, Nicolás, Falzone, Tomas Luis, Marin Burgin, Antonia, Otero, Maria Gabriela, Pardi, María Belén, Pozo Devoto, Victorio Martin, Saez, Trinidad María de Los Milagros, Scassa, Maria Elida, Schinder, Alejandro Fabián, Sevlever, Gustavo, Stokin, Gorazd B.   +12 more
core   +1 more source

Mitochondrial fusion: Reaching the end of mitofusin’s tether [PDF]

Journal of Cell Biology, 2016
In this issue, Qi et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201609019) provide structural insights into the mechanisms of mitochondrial outer membrane fusion by investigating the structure of mitofusin 1 (MFN1). This work proposes a new model to explain the important and elusive process of MFN-mediated mitochondrial fusion.
Formosa, Luke E., Ryan, Michael T.
openaire   +2 more sources

Myo‐Inositol Mitigates Oxidative Stress in Bovine Mammary Epithelial Cells via Activation of the SIRT5/Nrf2 Signaling Axis

Animal Research and One Health, EarlyView.
Myo‐inositol alleviates oxidative stress in dairy cow mammary epithelial cells via the Sirt5/Nrf2 pathway to promote mitochondrial fusion. This graphical abstract was created with BioRender.com. ABSTRACT High‐yielding dairy cows are susceptible to mammary gland oxidative stress due to prolonged intensive lactation, leading to redox imbalance.
Yufei Zhang, Yu Cao, Meng Zhang, Huijie Hu, He Ma, Junlong Bi, Juxiong Liu, Shoupeng Fu, Wenjin Guo   +8 more
wiley   +1 more source

Structural dataset from microsecond-long simulations of yeast mitofusin Fzo1 in the context of membrane docking

Data in Brief, 2019
In this work we present a novel set of possible auto-oligomerisation states of yeast protein Fzo1 in the context of membrane docking. The dataset reports atomistic models and trajectories derived from a molecular dynamics study of the yeast mitofusin ...
Astrid Brandner, Dario De Vecchis, Marc Baaden, Mickael M. Cohen, Antoine Taly   +4 more
doaj   +1 more source

Mitochonic acid 5 regulates mitofusin 2 to protect microglia

Neural Regeneration Research, 2021
Microglial apoptosis is associated with neuroinflammation and no effective strategies are currently available to protect microglia against inflammation-induced apoptosis.
Jian Tan, Shuang-Xi Chen, Qing-Yun Lei, Shan-Qing Yi, Na Wu, Yi-Lin Wang, Zi-Jian Xiao, Heng Wu   +7 more
doaj   +1 more source

Lin28A induces energetic switching to glycolytic metabolism in human embryonic kidney cells [PDF]

, 2016
Background: Loss of a cell’s capacity to generate sufficient energy for cellular functions is a key hallmark of the ageing process and ultimately leads to a variety of important age-related pathologies such as cancer, Parkinson’s disease and ...
Docherty, Craig K., Mercer, John R., Salt, Ian P.   +2 more
core   +3 more sources

Unveiling the role of mitofusin proteins in periodontal inflammation: Mitofusin-1 and Mitofusin-2 perspectives

Tanta Dental Journal
Abstract Periodontal diseases result from the complex interplay between microbial pathogens and the host immune response. Emerging evidence suggests that alterations in mitochondrial dynamics proteins, particularly Mitofusin-1 (MFN1) and Mitofusin-2 (MFN2), contribute to the pathogenesis of periodontal inflammation.
Himani Sharma, Umang Tripathi
openaire   +1 more source

Biomaterial design strategies for enhancing mitochondrial transplantation therapy

BMEMat, EarlyView.
Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang, Yushan Zhang, Hang Li, Sirui Peng, Donghao Lyu, Chunxiao Zhou, Sheng Ding, Zujian Feng, Pingsheng Huang, Chuangnian Zhang, Hongjun Wang, Deling Kong, Weiwei Wang   +12 more
wiley   +1 more source

A membrane-inserted structural model of the yeast mitofusin Fzo1 [PDF]

, 2017
Mitofusins are large transmembrane GTPases of the dynamin-related protein family, and are required for the tethering and fusion of mitochondrial outer membranes.
A Fiser, A Franco, A Lupas, A Sali, A Santel, AA Polyansky, AB Knott, AM Bertholet, B Brosig, B Hess, B Westermann, C Notredame, C Volland, CR Søndergaard, D Naon, D Rapaport, DT Jones, DT Jones, E Boutet, EE Griffin, EF Pettersen, EG Hutchinson, F Anton, F Anton, F Armougom, F Sievers, G Pollastri, GJ Hermann, H Kishida, H Sesaki, H Viklund, HH Low, HH Low, HJC Berendsen, HM Berman, IM Wallace, JM Mason, JS Chappie, K Hofmann, K Labbé, L Cavellini, L Yan, L Yan, M Escobar-Henriques, M Rojo, M-P Durrieu, M-Y Shen, MA Lemmon, MA Lomize, MM Cohen, MS Longtine, N Ishihara, NJ Gleason, O Daumke, OM Brito de, P Hubert, R Filadi, R Yan, RA Laskowski, RA Laskowski, RFS Walters, RL Dunbrack, S Fritz, S Jo, S Lee, S-Q Zhang, SF Altschul, T Darden, T Koshiba, T Nugent, T Shutt, TJ Dolinsky, VB Chen, W Kabsch, WL Jorgensen, X Bian, X Daura, Y Qi, Y-L Cao   +78 more
core   +4 more sources