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Mitofusin-2: Functional switch between mitochondrial function and neurodegeneration
Mitochondrion, 2023Mitochondria are highly dynamic organelles known to play role in the regulation of several cellular biological processes. However, their dynamics such as number, shape, and biological functions are regulated by mitochondrial fusion and fission process.
Prakash G. Kulkarni +6 more
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Mitofusin-2 is a novel direct target of p53
Biochemical and Biophysical Research Communications, 2010The tumor suppressor p53 modulates transcription of a number of target genes involved in cell cycle arrest, apoptosis, DNA repair, and other important cellular responses. Mitofusin-2 (Mfn2) is a novel suppressor of cell proliferation that may also exert apoptotic effects via the mitochondrial apoptotic pathway.
Weilin, Wang +9 more
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miR-106a promotes cardiac hypertrophy by targeting mitofusin 2
Journal of Molecular and Cellular Cardiology, 2016Pathological cardiac hypertrophy is a main factor leading to heart failure and associated sudden death. Improved understanding of the underlying molecular mechanisms should aid better treatment of the disease. This study aimed to test our hypothesis that a microRNA miR-106a played an important role in the development of cardiac hypertrophy through ...
Xiaoxiang, Guan +11 more
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IKKβ stabilizes Mitofusin 2 and suppresses doxorubicin cardiomyopathy
Cardiovascular ResearchAbstract Aims The mitochondrial dynamics protein Mitofusin 2 (MFN2) coordinates critical cellular processes including mitochondrial bioenergetics, quality control, and cell viability. The NF-κB kinase IKKβ suppresses mitochondrial injury in doxorubicin cardiomyopathy, but the underlying mechanism is ...
Matthew Guberman +6 more
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Mitofusin 1 and Mitofusin 2 Function in the Context of Brain Development
2011Mitofusin 1 and 2 are outer-mitochondrial membrane proteins that have been shown to be involved in fusion. Mitofusin 2 has also been associated with apoptosis and development. When Mfn1 and Mfn2 were each conditionally knocked out from the cerebellum, Purkinje cells in Mfn2 deficient cerebellum during development had undergone neurodegeneration ...
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A human mitofusin 2 mutation causes mitophagic cardiomyopathy
2022Abstract Cardiac muscle has the highest mitochondrial density of any human tissue, but mitochondrial dysfunction is not a recognized cause of isolated cardiomyopathy. Here, we determined that the rare mitofusin (MFN) 2 R400Q mutation is ~20x over-represented in clinical cardiomyopathy, whereas this specific mutation ...
Antonietta Franco +11 more
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Research Progress of Mitofusin-2*
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2010Guang-Ju ZHAO +2 more
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Integrative oncology: Addressing the global challenges of cancer prevention and treatment
Ca-A Cancer Journal for Clinicians, 2022Jun J Mao,, Msce +2 more
exaly
Multidisciplinary standards of care and recent progress in pancreatic ductal adenocarcinoma
Ca-A Cancer Journal for Clinicians, 2020Aaron J Grossberg +2 more
exaly