Results 211 to 220 of about 17,474 (245)
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Conditional deletion of myeloid-specific mitofusin 2 but not mitofusin 1 promotes kidney fibrosis
Kidney International, 2022Macrophages exert critical functions during kidney injury, inflammation, and tissue repair or fibrosis. Mitochondrial structural and functional aberrations due to an imbalance in mitochondrial fusion/fission processes are implicated in the pathogenesis of chronic kidney disease.
Divya Bhatia +6 more
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Mitofusin 2 tethers endoplasmic reticulum to mitochondria
Nature, 2008Juxtaposition between endoplasmic reticulum (ER) and mitochondria is a common structural feature, providing the physical basis for intercommunication during Ca(2+) signalling; yet, the molecular mechanisms controlling this interaction are unknown. Here we show that mitofusin 2, a mitochondrial dynamin-related protein mutated in the inherited motor ...
Luca Scorrano
exaly +5 more sources
Mitofusin-2 in cancer: Friend or foe?
Archives of Biochemistry and Biophysics, 2022Cancer is a category of disorders characterized by excessive cell proliferation with the ability to infiltrate or disseminate to other organs of the body. Mitochondrial dysfunction, as one of the most prominent hallmarks of cancer cells, has been related to the onset and development of various cancers.
Pushpamala, Ramaiah +10 more
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Reproductive Sciences, 2022
Mitochondria are dynamic organelles that regulate their size, shape, and morphology through mechanisms called fusion and fission, to continually adapt themselves to their bioenergetic environment. These mechanisms play a critical role to maintain the mitochondrial function under metabolic and environmental stress.
Mauro Cozzolino, Yagmur Ergun, Emre Seli
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Mitochondria are dynamic organelles that regulate their size, shape, and morphology through mechanisms called fusion and fission, to continually adapt themselves to their bioenergetic environment. These mechanisms play a critical role to maintain the mitochondrial function under metabolic and environmental stress.
Mauro Cozzolino, Yagmur Ergun, Emre Seli
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Mitofusin-2 is a novel direct target of p53
Biochemical and Biophysical Research Communications, 2010The tumor suppressor p53 modulates transcription of a number of target genes involved in cell cycle arrest, apoptosis, DNA repair, and other important cellular responses. Mitofusin-2 (Mfn2) is a novel suppressor of cell proliferation that may also exert apoptotic effects via the mitochondrial apoptotic pathway.
Weilin, Wang +9 more
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Role of mitofusin 2 in cardiovascular oxidative injury
Journal of Molecular Medicine, 2010Mitochondria are highly dynamic organelles with constant shape changes regulated by fusion and fission events. In addition to regulating mitochondrial morphology, mitochondrial fusion/fission is involved in fundamental mitochondrial biological processes, including mitochondrial metabolism, energization, respiration, mitochondrial membrane potential ...
Ming, Zheng, Rui-Ping, Xiao
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Relationship between mitofusin 2 and cancer
2019Mitochondria are dynamic organelles whose actions are fundamental for cell viability. Within the cell, the mitochondrial system is incessantly modified via the balance between fusion and fission processes. Among other proteins, mitofusin 2 is a central protagonist in all these mitochondrial events (fusion, trafficking, contacts with other organelles ...
A. Allegra +3 more
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Mitofusin 2 ablation increases endoplasmic reticulum–mitochondria coupling [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2015 Significance The privileged interrelationship between mitochondria and the endoplasmic reticulum (ER) plays a key role in a variety of physiological functions, from lipid metabolism to Ca 2+ signalling, and its modulation influences apoptotic susceptibility, mitophagy, and ...
Riccardo Filadi +2 more
exaly +4 more sources
Mitofusin 2 Inhibits Mitochondrial Antiviral Signaling
Science Signaling, 2009A protein that mediates mitochondrial fusion also suppresses innate immune responses to viral infection.
Kai, Yasukawa +7 more
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Highlighting the endoplasmic reticulum-mitochondria connection: Focus on Mitofusin 2
Pharmacological Research, 2018 The endoplasmic reticulum (ER) and the mitochondrial network are two highly interconnected cellular structures. By proteinaceous tethers, specialized membrane domains of the ER are tightly associated with the outer membrane of mitochondria, allowing the assembly of signaling platforms where different cell functions take place or are modulated, such as ...
Riccardo Filadi +2 more
exaly +4 more sources