Results 221 to 230 of about 17,474 (245)

Doxorubicin-induced cardiomyocyte apoptosis: Role of mitofusin 2

The International Journal of Biochemistry & Cell Biology, 2017
Doxorubicin (DOX) is an anti-tumor agent that is widely used in clinical setting for cancer treatment. The application of the DOX, however, is limited by its cardiac toxicity which can induce heart failure through an undefined mechanism. Mitofusin 2 (Mfn2) is a mitochondrial GTPase fusion protein that is located on the outer membrane of mitochondria ...
Han, Tang, Aibin, Tao, Jia, Song, Qian, Liu, Hao, Wang, Tao, Rui   +5 more
openaire   +2 more sources

Mitofusin 1 and Mitofusin 2 Function in the Context of Brain Development

2011
Mitofusin 1 and 2 are outer-mitochondrial membrane proteins that have been shown to be involved in fusion. Mitofusin 2 has also been associated with apoptosis and development. When Mfn1 and Mfn2 were each conditionally knocked out from the cerebellum, Purkinje cells in Mfn2 deficient cerebellum during development had undergone neurodegeneration ...
openaire   +2 more sources

Altered expression of mitofusin 2 in penile tissues of diabetic rats

Andrologia, 2013
Diabetic erectile dysfunction (ED) is a common complication in diabetes mellitus, and the efficacy of first-line therapies is not satisfactory. Recent studies revealed that corporal apoptosis was responsible for the nonresponsiveness of severe ED to phosphodiesterase type 5 inhibitors. Mitofusin 2 (Mfn2) is a versatile protein, regulating mitochondrial
J, Yang, T, Wang, Y, Zhang, R, Li, S, Wang, H, Xu, J, Liu, Z, Ye   +7 more
openaire   +2 more sources

IKKβ stabilizes Mitofusin 2 and suppresses doxorubicin cardiomyopathy

Cardiovascular Research
Abstract Aims The mitochondrial dynamics protein Mitofusin 2 (MFN2) coordinates critical cellular processes including mitochondrial bioenergetics, quality control, and cell viability. The NF-κB kinase IKKβ suppresses mitochondrial injury in doxorubicin cardiomyopathy, but the underlying mechanism is ...
Matthew Guberman, Rimpy Dhingra, Jenna Cross, Victoria Margulets, Hongying Gang, Inna Rabinovich-Nikitin, Lorrie A Kirshenbaum   +6 more
openaire   +2 more sources

Research Progress of Mitofusin-2*

PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2010
Guang-Ju ZHAO, Zhong-Qiu LU, Yong-Ming YAO   +2 more
openaire   +1 more source

E4 ubiquitin ligase promotes mitofusin turnover and mitochondrial stress response

Molecular Cell, 2023
Vincent Anton, Tania Simöes, Reinhard Büttner   +2 more
exaly  

Mitofusin 2 in Macrophages Links Mitochondrial ROS Production, Cytokine Release, Phagocytosis, Autophagy, and Bactericidal Activity

Cell Reports, 2020
Pere-Joan Cardona, Antonio Zorzano, Jorge Lloberas   +2 more
exaly  

Regulation of mitofusin-2 expression in skeletal muscle.

Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 2009
Fusion and fission of mitochondria regulate their morphology and distribution. Mitofusin-2 (Mfn2) is a mitochondrial protein involved in such fusion. Recent observations indicate that Mfn2 is a multifunctional protein that participates in cell proliferation and metabolism and that it is required for normal endoplasmic reticulum morphology.
openaire   +1 more source

Loss of Macrophage Mitofusin 2 but Not Mitofusin 1 Suppresses Mitochondrial Biogenesis and Promotes Kidney Fibrosis

Journal of the American Society of Nephrology, 2021
Divya Bhatia, Allyson M. Capili, Kiichi Nakahira, Thangamani Muthukumar, Augustine M. Choi, Mary E. Choi   +5 more
openaire   +1 more source

Mitofusin gain and loss of function drive pathogenesis in Drosophila models of CMT 2A neuropathy

EMBO Reports, 2018
Manuel Rojo, Gabriela Poliacikova, Julien Royet   +2 more
exaly