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The mitophagy pathway and its implications in human diseases
Signal Transduction and Targeted Therapy, 2023 Mitochondria are dynamic organelles with multiple functions. They participate in necrotic cell death and programmed apoptotic, and are crucial for cell metabolism and survival.
Shouliang Wang +9 more
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Nature Reviews Molecular Cell Biology, 2010 Autophagy not only recycles intracellular components to compensate for nutrient deprivation but also selectively eliminates organelles to regulate their number and maintain quality control. Mitophagy, the specific autophagic elimination of mitochondria, has been identified in yeast, mediated by autophagy-related 32 (Atg32), and in mammals during red ...
Richard J Youle, Derek P Narendra
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Parkin-Independent Mitophagy Controls Chemotherapeutic Response in Cancer Cells [PDF]
Cell Reports, 2017 Mitophagy is an evolutionarily conserved process that selectively targets impaired mitochondria for degradation. Defects in mitophagy are often associated with diverse pathologies, including cancer.
Elodie Villa +13 more
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HIF1a-dependent mitophagy facilitates cardiomyoblast differentiation [PDF]
Cell Stress, 2020 Mitophagy is thought to play a key role in eliminating damaged mitochondria, with diseases such as cancer and neurodegeneration exhibiting defects in this process.
Jin-Feng Zhao +4 more
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The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy
Nature, 2015 Protein aggregates and damaged organelles are tagged with ubiquitin chains to trigger selective autophagy. To initiate mitophagy, the ubiquitin kinase PINK1 phosphorylates ubiquitin to activate the ubiquitin ligase parkin, which builds ubiquitin chains ...
Michael Lazarou +2 more
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Targeting MCL1 by UMI-77 to induce mitophagy alleviates renal tubular epithelial cells injury in acute kidney injury [PDF]
Scientific ReportsAcute kidney injury (AKI) is a common clinical disease with complex pathophysiological processes and with high morbidity and mortality. Severe mitochondrial damages, such as mitochondrial swelling and fragmentation, disruption of membrane integrity, and ...
Xiaoyu Li +10 more
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Nature Biomedical Engineering, 2022 A reduced removal of dysfunctional mitochondria is common to aging and age-related neurodegenerative pathologies such as Alzheimer’s disease (AD).
Xu-Xu Zhuang, Ruixue Ai, Sofie Lautrup
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Targeting cellular mitophagy as a strategy for human cancers
Frontiers in Cell and Developmental BiologyMitophagy is the cellular process to selectively eliminate dysfunctional mitochondria, governing the number and quality of mitochondria. Dysregulation of mitophagy may lead to the accumulation of damaged mitochondria, which plays an important role in the
Yuming Dong, Xue Zhang
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The conserved outer mitochondrial membrane protein Mtch regulates mitophagy during Drosophila intestinal development. [PDF]
PLoS BiologyThe clearance of mitochondria by autophagy (mitophagy) is important for cell health. Mutations in genes that are required for mitophagy, including Vps13D, PINK1, and Parkin, are associated with movement disorders, but gaps exist in our understanding of ...
Lucas J Restrepo +3 more
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