Results 11 to 20 of about 96,831 (392)
Mitophagy for cardioprotection
Basic Research in Cardiology, 2023 Mitochondrial function is maintained by several strictly coordinated mechanisms, collectively termed mitochondrial quality control mechanisms, including fusion and fission, degradation, and biogenesis.
Allen Sam Titus +3 more
semanticscholar +3 more sources
Mitophagy in neurological disorders [PDF]
Journal of Neuroinflammation, 2021 Selective autophagy is an evolutionarily conserved mechanism that removes excess protein aggregates and damaged intracellular components. Most eukaryotic cells, including neurons, rely on proficient mitophagy responses to fine-tune the mitochondrial ...
Lijun Zhang, Lei Dai, Deyuan Li
doaj +3 more sources
Mitophagy regulates kidney diseases
Kidney DiseasesBackground: Mitophagy is a crucial process involved in maintaining cellular homeostasis by selectively eliminating damaged or surplus mitochondria. As the kidney is an organ with a high dynamic metabolic rate and abundant mitochondria, it is particularly
Xiaolu Fan +5 more
doaj +3 more sources
Role of mitophagy in breast cancer: mitophagy-apoptosis balance and reactive oxygen species play determining role [PDF]
Frontiers in PhysiologyThis review aims to present a current overview of the role of mitophagy in breast cancer progression, especially from the point of view of when the cancer is in the untreated state or under chemotherapeutic treatment.
Lung Yiu +6 more
doaj +2 more sources
Mitophagy and Neuroprotection [PDF]
Trends in Molecular Medicine, 2020 Neurodegenerative diseases are strongly age-related and currently cannot be cured, with a surge of patient numbers in the coming decades in view of the emerging worldwide ageing population, bringing healthcare and socioeconomic challenges. Effective therapies are urgently needed, and are dependent on new aetiological mechanisms.
Lou, Guofeng +5 more
openaire +4 more sources
Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy
Science, 2011 Maria M Mihaylova +2 more
exaly +2 more sources
Cellular mitophagy: Mechanism, roles in diseases and small molecule pharmacological regulation
Theranostics, 2023 Cellular mitophagy means that cells selectively wrap and degrade damaged mitochondria through an autophagy mechanism, thus maintaining mitochondria and intracellular homeostasis.
Yingying Lu +5 more
semanticscholar +1 more source
PINK1-parkin-mediated neuronal mitophagy deficiency in prion disease
Cell Death and Disease, 2022 A persistent accumulation of damaged mitochondria is part of prion disease pathogenesis. Normally, damaged mitochondria are cleared via a major pathway that involves the E3 ubiquitin ligase parkin and PTEN-induced kinase 1 (PINK1) that together initiate ...
Jie Li +12 more
doaj +1 more source
Mitophagy in Human Diseases [PDF]
International Journal of Molecular Sciences, 2021 Mitophagy is a selective autophagic process, essential for cellular homeostasis, that eliminates dysfunctional mitochondria. Activated by inner membrane depolarization, it plays an important role during development and is fundamental in highly differentiated post-mitotic cells that are highly dependent on aerobic metabolism, such as neurons, muscle ...
Laura Doblado +6 more
openaire +4 more sources
Molecular mechanisms and physiological functions of mitophagy
EMBO Journal, 2021 Degradation of mitochondria via a selective form of autophagy, named mitophagy, is a fundamental mechanism conserved from yeast to humans that regulates mitochondrial quality and quantity control.
Mashun Onishi +4 more
semanticscholar +1 more source