Results 11 to 20 of about 75,749 (306)
HIF1a-dependent mitophagy facilitates cardiomyoblast differentiation [PDF]
Cell Stress, 2020 Mitophagy is thought to play a key role in eliminating damaged mitochondria, with diseases such as cancer and neurodegeneration exhibiting defects in this process.
Jin-Feng Zhao +4 more
doaj +5 more sources
The mitophagy pathway and its implications in human diseases
Signal Transduction and Targeted Therapy, 2023 Mitochondria are dynamic organelles with multiple functions. They participate in necrotic cell death and programmed apoptotic, and are crucial for cell metabolism and survival.
Shouliang Wang +9 more
exaly +2 more sources
Parkin-Independent Mitophagy Controls Chemotherapeutic Response in Cancer Cells [PDF]
Cell Reports, 2017 Mitophagy is an evolutionarily conserved process that selectively targets impaired mitochondria for degradation. Defects in mitophagy are often associated with diverse pathologies, including cancer.
Elodie Villa +13 more
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Mitophagy in neurological disorders [PDF]
Journal of Neuroinflammation, 2021 Selective autophagy is an evolutionarily conserved mechanism that removes excess protein aggregates and damaged intracellular components. Most eukaryotic cells, including neurons, rely on proficient mitophagy responses to fine-tune the mitochondrial ...
Lijun Zhang, Lei Dai, Deyuan Li
doaj +3 more sources
Role of mitophagy in breast cancer: mitophagy-apoptosis balance and reactive oxygen species play determining role [PDF]
Frontiers in PhysiologyThis review aims to present a current overview of the role of mitophagy in breast cancer progression, especially from the point of view of when the cancer is in the untreated state or under chemotherapeutic treatment.
Lung Yiu +6 more
doaj +2 more sources
Mitophagy regulates kidney diseases
Kidney DiseasesBackground: Mitophagy is a crucial process involved in maintaining cellular homeostasis by selectively eliminating damaged or surplus mitochondria. As the kidney is an organ with a high dynamic metabolic rate and abundant mitochondria, it is particularly
Xiaolu Fan +5 more
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Mitophagy and Neuroprotection [PDF]
Trends in Molecular Medicine, 2020 Neurodegenerative diseases are strongly age-related and currently cannot be cured, with a surge of patient numbers in the coming decades in view of the emerging worldwide ageing population, bringing healthcare and socioeconomic challenges. Effective therapies are urgently needed, and are dependent on new aetiological mechanisms.
Lou, Guofeng +5 more
openaire +4 more sources
PINK1-parkin-mediated neuronal mitophagy deficiency in prion disease
Cell Death and Disease, 2022 A persistent accumulation of damaged mitochondria is part of prion disease pathogenesis. Normally, damaged mitochondria are cleared via a major pathway that involves the E3 ubiquitin ligase parkin and PTEN-induced kinase 1 (PINK1) that together initiate ...
Jie Li +12 more
doaj +1 more source
Mitophagy in Human Diseases [PDF]
International Journal of Molecular Sciences, 2021 Mitophagy is a selective autophagic process, essential for cellular homeostasis, that eliminates dysfunctional mitochondria. Activated by inner membrane depolarization, it plays an important role during development and is fundamental in highly differentiated post-mitotic cells that are highly dependent on aerobic metabolism, such as neurons, muscle ...
Laura Doblado +6 more
openaire +4 more sources
Mitophagy Transcriptome: Mechanistic Insights into Polyphenol‐Mediated Mitophagy [PDF]
Oxidative Medicine and Cellular Longevity, 2017 Mitochondria are important bioenergetic and signalling hubs critical for myriad cellular functions and homeostasis. Dysfunction in mitochondria is a central theme in aging and diseases. Mitophagy, a process whereby damaged mitochondria are selectively removed by autophagy, plays a key homeostatic role in mitochondrial quality control.
Sijie Tan, Esther Wong
openaire +5 more sources