Results 21 to 30 of about 96,831 (392)
Mitophagy Transcriptome: Mechanistic Insights into Polyphenol‐Mediated Mitophagy [PDF]
Oxidative Medicine and Cellular Longevity, 2017 Mitochondria are important bioenergetic and signalling hubs critical for myriad cellular functions and homeostasis. Dysfunction in mitochondria is a central theme in aging and diseases. Mitophagy, a process whereby damaged mitochondria are selectively removed by autophagy, plays a key homeostatic role in mitochondrial quality control.
Sijie Tan, Esther Wong
openaire +5 more sources
Redox Biology, 2021 Mitochondrial dysfunction is a fundamental challenge in septic cardiomyopathy. Mitophagy and the mitochondrial unfolded protein response (UPRmt) are the predominant stress-responsive and protective mechanisms involved in repairing damaged mitochondria ...
Yue Wang +5 more
doaj +1 more source
Open Medicine, 2021 Mitophagy affects the activation of hepatic stellate cells (HSCs). Mitochondria-targeted ubiquinone (MitoQ) is a mitochondria-targeted antioxidant that reduces the production of intracellular reactive oxygen species (ROS).
Dou Shi-Ying +7 more
doaj +1 more source
Mitochondria ROS and mitophagy in acute kidney injury
Autophagy, 2022 Mitophagy is an essential mitochondrial quality control mechanism that eliminates damaged mitochondria and the production of reactive oxygen species (ROS).
L. Su +4 more
semanticscholar +1 more source
Chemical mitophagy modulators: Drug development strategies and novel regulatory mechanisms
Pharmacological Research, 2023 Maintaining mitochondrial homeostasis is a potential therapeutic strategy for various diseases, including neurodegenerative diseases, cardiovascular diseases, metabolic disorders, and cancer. Selective degradation of mitochondria by autophagy (mitophagy)
Yu Dong +10 more
doaj +1 more source
Baicalein Activates Parkin-Dependent Mitophagy through NDP52 and OPTN
Cells, 2022 The elimination of intracellular components by autophagy maintains metabolic homeostasis and is a quality-control pathway that enables organelle regeneration.
Po-Yuan Ke +2 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2023 Mitochondrial dysfunction is associated with ototoxicity, which is caused by external factors. Mitophagy plays a key role in maintaining mitochondrial homeostasis and function and is regulated by a series of key mitophagy regulatory proteins and signaling pathways.
Hezhou Han +7 more
openaire +3 more sources
Mitophagy Regulation Following Myocardial Infarction
Cells, 2022 Mitophagy, which mediates the selective elimination of dysfunctional mitochondria, is essential for cardiac homeostasis. Mitophagy is regulated mainly by PTEN-induced putative kinase protein-1 (PINK1)/parkin pathway but also by FUN14 domain-containing 1 (
Annie Turkieh +3 more
doaj +1 more source
Cancer & Metabolism, 2015 Mitophagy is a selective form of macro-autophagy in which mitochondria are selectively targeted for degradation in autophagolysosomes. Mitophagy can have the beneficial effect of eliminating old and/or damaged mitochondria, thus maintaining the integrity of the mitochondrial pool.
Chourasia, Aparajita H +2 more
openaire +2 more sources
Dysfunctional Mitochondria Clearance in Situ: Mitophagy in Obesity and Diabetes-Associated Cardiometabolic Diseases [PDF]
Diabetes & Metabolism JournalSeveral mitochondrial dysfunctions in obesity and diabetes include impaired mitochondrial membrane potential, excessive mitochondrial reactive oxygen species generation, reduced mitochondrial DNA, increased mitochondrial Ca2+ flux, and mitochondrial ...
Songling Tang +8 more
doaj +1 more source