Results 141 to 150 of about 130,672 (286)

RAB4A acts as a negative feedback regulator of extracellular vesicle secretion during TGF‐β signaling

The FEBS Journal, EarlyView.
TGF‐β signaling regulates extracellular vesicle (EV) release in cancer cells by modulating the expression and activity of genes associated with EV biogenesis. The TGF‐β‐induced upregulation of RAB4A expression facilitates fast endosomal recycling, a process that limits the fusion of multivesicular bodies with the plasma membrane and EV secretion. Hence,
Dorival Mendes Rodrigues‐Junior, Maria Anastasia Doumani, Hao Fu, Jelle van den Bor, Olof Idevall‐Hagren, Aristidis Moustakas   +5 more
wiley   +1 more source

Ossifying spindled and epithelioid tumour: Expanding the clinical and morphologic spectrum of a recently described entity

Histopathology, EarlyView.
Ossifying spindled and epithelioid tumour (OSET) can show unusual morphologic features, including minimal or absent peripheral ossification, eosinophil‐rich stroma, increased mitotic activity (≥5 mitotic figures per 10 high‐power fields), and necrosis.
Rayan M Sibira, Benjamin F Smith, Amy Davis, Jessica L Davis, Nada Mohamed, Riyam Zreik, David J Papke Jr., Michael Michal, Sintawat Wangsiricharoen, Karen J Fritchie   +9 more
wiley   +1 more source

TANC1::HTRA1 fusion in schwannomas

Brain Pathology, EarlyView.
Ilay Caliskan, Kanish Mirchia, Walter Patrick Devine, Melike Pekmezci   +3 more
wiley   +1 more source

World Health Organization classification of tumours of the breast 6th edition 2026

Histopathology, EarlyView.
The 6th edition of the World Health Organization Classification of Breast Tumours introduces changes based on recent advances in our understanding of breast biology, developments in diagnostic modalities, identification of specific molecular targets and new treatment regimes.
Cecily Quinn, Puay Hoon Tan, Kimberly H Allison, Edi Brogi, Sunil R Lakhani, Stuart J Schnitt, Stephen B Fox, Shabnam Jaffer, Aysegul Sahin, Roberto Salgado, Anna Sapino, Ernest Kwasi Adjei, Katherine Geiersbach, Thomas H Helbich, Matteo Lambertini, Christos Sotiriou, Jennelle C Hodge, Joseph D Khoury, Bharat Rekhi, Ales Ryska, Gary Tse, Andrew Field, Harshima Wijesinghe, Pavitratha Puspanathan, Christine Giesen, Blanca Iciar Indave Ruiz, Ian Ellis, Dilani Lokuhetty, WCT Standing Editorial Board, Wendy Cooper, Michael Eden, Andrew Field, Vicky Goh, Jennelle C. Hodge, James Kench, Joseph D. Khoury, Katia Leite, Zhiyong Liang, Daichi Maeda, George Netto, Bharat Rekhi, Miguel Reyes Mugica, Brian Rous, Ales Ryska, Shahin Sayed, Antonia Sepulveda, Chanjuan Shi, Gary Tse   +47 more
wiley   +1 more source

Developmental expression of Ap‐Vas proteins in aphids and flies reveals their evolutionary roles in insects

Insect Molecular Biology, EarlyView.
Duplication of vas genes is universally observed in aphids, and phylogenetic analysis indicates that this event predates the divergence of Aphididae and Phylloxeridae. Ap‐vas1 is germline‐specific, whereas Ap‐vas2–4 exhibit somatic expression, indicating functional divergence during aphid embryogenesis.
Gee‐Way Lin, Szu‐Chieh Wang, Charles E. Cook, Ming‐Der Lin, Chun‐che Chang   +4 more
wiley   +1 more source

Traumatic Occlusion Exacerbates Bone Resorption by Modifying Gene Expression in the Bone Tissue of Ligature‐Induced Periodontitis in Mice

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Aim To clarify the molecular mechanisms of occlusal trauma in bone loss through periodontal tissue transcriptome analysis in mice with periodontitis and traumatic occlusion. Materials and Methods Ligature‐induced periodontitis (Li) and composite resin‐induced traumatic occlusion (Tra) mouse models were established (control [Co], Li, Tra and ...
Yosuke Tsuchiya, Yujin Ohsugi, Tomomitsu Hirota, Yohei Hayashi, Peiya Lin, Yuta Tsukahara, Takanori Iwata, Sayaka Katagiri   +7 more
wiley   +1 more source

ALK Expression in Nerve Sheath Myxoma: A Potential Diagnostic Pitfall

Journal of Cutaneous Pathology, EarlyView.
Daniel Cole, May P. Chan, Douglas Rottmann, Bryan L. Betz, Noah Brown, Venezia Podesta, Paul W. Harms   +6 more
wiley   +1 more source

From observation to understanding: A multi‐agent framework for smart microscopy

Journal of Microscopy, EarlyView.
Abstract Smart microscopy represents a paradigm shift in biological imaging, moving from passive observation tools to active collaborators in scientific inquiry. Enabled by advances in automation, computational power, and artificial intelligence, these systems are now capable of adaptive decision‐making and real‐time experimental control.
P. S. Kesavan, Pontus Nordenfelt
wiley   +1 more source

Clinicopathological and Prognostic Features of Pleomorphic Adenoma, Recurrent Pleomorphic Adenoma, and Carcinoma ex Pleomorphic Adenoma: A 20‐Year Retrospective Analysis

Oral Diseases, EarlyView.
ABSTRACT Background Pleomorphic adenoma (PA) is the most common salivary gland tumor, and a subset may recur as recurrent PA (RPA) or progress to carcinoma ex pleomorphic adenoma (CXPA). However, comparative evaluations of their biological behavior and prognostic factors remain limited.
Talita de Carvalho Kimura, Luccas Lavareze, Reydson Alcides de Lima‐Souza, Nívia Castro Binda, Carlos Takahiro Chone, Alfio José Tincani, Albina Altemani, Fernanda Viviane Mariano   +7 more
wiley   +1 more source

Mitotic spindle perturbations

, 2016
Microtubules are major components of the cytoskeleton and form the bipolar spindle apparatus during mitosis. The mitotic spindle consists of highly dynamic microtubule polymers that are under constant modulation, controlled by multiple motor proteins and microtubule-associated proteins.
openaire   +1 more source