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Cosmeceutical Potential of Mitragyna speciosa (Kratom): Anti-Adipogenic and Antioxidant Properties of Extracts and Mitragynine [PDF]

Molecules
Kratom (Mitragyna speciosa (Korth.) Havil.) is a medicinal plant containing bioactive alkaloids, notably mitragynine and 7-hydroxymitragynine, which are psychoactive compounds with analgesic and stimulant properties.
Sudthiworarak Kaewchompoo, Prapapan Temkitthawon, Kalyarut Phumlek, Neti Waranuch, Ngamrayu Ngamdokmai, Kornkanok Ingkaninan   +5 more
doaj   +3 more sources

Inhibitory effects of Kratom constituents, mitragynine and 7-hydroxymitragynine, on 4-methylumbelliferone glucuronidation by human UDP-glucuronosyltransferases [PDF]

Toxicology Reports
As Kratom use increases, concerns about potential herb-drug interactions with liver enzymes, particularly UDP-glucuronosyltransferases (UGTs), have emerged.
Verawan Uchaipichat
doaj   +3 more sources

Bayesian inference for integrated pharmacokinetic modelling of mitragynine and 7-hydroxymitragynine [PDF]

ADMET and DMPK
Background and purpose: Mitragynine is an active compound in kratom that is metabolized to the pharmacologically active 7-hydroxymitragynine, requiring an integrated pharmacokinetic approach to maintain plasma concentrations of both within the optimal ...
Dion Notario, Untung Gunawan, Pretty Falena Atmanda Kambira, Erna Wulandari, Eko Adi Prasetyanto   +4 more
doaj   +2 more sources

Environmental Influence on the Untargeted Foliar Metabolome of Naturally Growing Mitragyna Species in Thailand [PDF]

Plant-Environment Interactions, Volume 7, Issue 1, February 2026.
ABSTRACT This study investigates the foliar secondary metabolite profiles of four Mitragyna species naturally occurring in Thailand: M. diversifolia, M. hirsuta, M. rotundifolia, and M. speciosa (kratom). Using untargeted gas chromatography–mass spectrometry (GC–MS), 409 secondary volatile metabolites were annotated across the four species.
Tushar Andriyas, Nisa Leksungnoen, Chatchai Ngernsaengsaruay, Suwimon Uthairatsamee, Rossarin Tansawat, Pakawat Sirilertpanich   +5 more
wiley   +2 more sources

Unravelling Rational Design of Molecularly Imprinted Polymer for Selective Mitragynine Isolation from Kratom: Quantum Mechanical, Molecular Dynamics, and Experimental Insights [PDF]

Molecules
Mitragyna speciosa, commonly referred to as kratom, is known for its active compound, mitragynine, which is classified as a new psychoactive substance. The availability of mitragynine standards remains a challenge, highlighting the need for effective and
Untung Gunawan, Eko Adi Prasetyanto, Pretty Falena Atmanda Kambira, Dion Notario, Erna Wulandari, Enade Perdana Istyastono, Andrea Tirta Wening, Kellie Irlianto, Atthar Luqman Ivansyah   +8 more
doaj   +2 more sources

Screening, docking, and molecular dynamics analysis of Mitragyna speciosa (Korth.) compounds for targeting HER2 in breast cancer [PDF]

Current Research in Structural Biology
Breast cancer remains the most commonly diagnosed cancer among women worldwide, with approximately 2.3 million new cases reported in 2022. In the United States alone, an estimated 310,720 new cases of female breast cancer are expected in 2024.
Nabila Hadiah Akbar, Farendina Suarantika, Taufik Muhammad Fakih, Ariranur Haniffadli, Khoirunnisa Muslimawati, Aditya Maulana Perdana Putra   +5 more
doaj   +2 more sources

In silico investigation of mitragynine and 7-hydroxymitragynine metabolism [PDF]

BMC Research Notes, 2019
Objective Mitragynine is the main active compound of Mitragyna speciose (Kratom in Thai). The understanding of mitragynine derivative metabolism in human body is required to develop effective detection techniques in case of drug abuse or establish an ...
Taweetham Limpanuparb, Rattha Noorat, Yuthana Tantirungrotechai   +2 more
doaj   +3 more sources

Alkaloid biosynthesis in medicinal crop kratom (Mitragyna speciosa) varies with postharvest, genetic, and seasonal factors [PDF]

Frontiers in Plant Science
IntroductionKratom (Mitragyna speciosa), a medicinally valuable ethnobotanical tree native to Southeast Asia, has traditionally been used to combat fatigue and enhance productivity.
Mengzi Zhang, Annabella Lyndon, Siva Rama Raju Kanumuri, Abhisheak Sharma, Abhisheak Sharma, Brian J. Pearson, Brian J. Pearson, Christopher R. McCurdy, Christopher R. McCurdy, Jianjun Chen   +9 more
doaj   +2 more sources

New psychoactive substances in roadway crash victims in California [PDF]

Frontiers in Toxicology
BackgroundMotor vehicle crashes (MVCs) are a major global health concern. While alcohol continues to be a significant contributor to MVCs, the role of illicit and prescription drugs has increased in the last 4 decades.
Roy Gerona, Daniel Tomer, Donovan Nielsen, Allyson C. Sage, Deborah French, Juliana Tolles, James Alan Chenoweth   +6 more
doaj   +2 more sources

Reported associations between kratom and seizures: a systematic review [PDF]

Frontiers in Pharmacology
Statement of purpose, innovation or hypothesisKratom, derived from the leaves of the plant Mitragyna speciosa, is an herbal supplement that has been used medically and recreationally for centuries, but has recently gained popularity in the United States ...
Toby Turla, Grayson Abele, My Hua, Dennis Paustenbach   +3 more
doaj   +2 more sources