Results 11 to 20 of about 2,942 (230)

Higher accumulation of mitragynine in Mitragyna speciosa (kratom) leaves affected by insect attack. [PDF]

PLoS ONE
Kratom leaves are widely consumed by locals to increase their stamina for working longer hours in the field. However, insect damage to the leaves can lead to significant loss of leaf harvest. Despite this, there remains considerable uncertainty regarding
Nisa Leksungnoen, Tushar Andriyas, Rossarin Tansawat, Pichaya Pongchaidacha, Piyawadi Khaoiam, Thanundorn Thanusuwannasak, Chatchai Ngernsaengsaruay, Chawatat Thanoosing, Suwimon Uthairatsamee   +8 more
doaj   +3 more sources

Exploring the Therapeutic Potential of Mitragynine and Corynoxeine: Kratom-Derived Indole and Oxindole Alkaloids for Pain Management [PDF]

Pharmaceuticals
The search for effective pain management solutions remains a critical challenge, especially amidst growing concerns over the use of conventional opioids.
Ahmed S. Alford, Hope L. Moreno, Menny M. Benjamin, Cody F. Dickinson, Mark T. Hamann   +4 more
doaj   +3 more sources

An exploratory study of the safety profile and neurocognitive function after single doses of mitragynine in humans [PDF]

Psychopharmacology (Berl)
© 2024 The Author(s). This is an open access article under the Creative Commons Attribution Non-Commercial No-Derivatives CC BY-NC-ND licence, https://creativecommons.org/licenses/by-nc-nd/4.0/Rationale Despite the growing scientific interest on ...
Bersani, Giuseppe, Cavarra, Mauro, Corazza, Ornella, Kuypers, Kim P. C., Paci, Riccardo, Pasquini, Massimo, Prevete, Elisabeth, Ramaekers, Johannes G., Reckweg, Johannes T., Ritscher, Sabrina, Theunissen, Eef L., Toennes, Stefan W.   +11 more
core   +5 more sources

Human Mitragynine and 7-Hydroxymitragynine Pharmacokinetics after Single and Multiple Daily Doses of Oral Encapsulated Dried Kratom Leaf Powder

Molecules
Kratom leaves, consumed by millions worldwide as tea or ground leaf powder, contain multiple alkaloids, with mitragynine being the most abundant and responsible for most effects.
Marilyn A. Huestis, Martin A. Brett, John Bothmer, Ramsey Atallah   +3 more
doaj   +2 more sources

Epidemiology of New Psychoactive Substances in Relation to Traditional Drugs of Abuse in Clinical Oral Fluid Samples [PDF]

Basic &Clinical Pharmacology &Toxicology, Volume 136, Issue 2, February 2025.
ABSTRACT New psychoactive substances (NPS) are health‐hazardous through unpredictable toxicity and effects and largely unknown epidemiology, motivating studies of the latter. Up to 138 NPS were retrospectively identified using liquid chromatography‐high resolution mass spectrometry data from all 34 183 oral fluid drug samples collected in one Swedish ...
Magnus A. B. Axelsson, Hanna Lövgren, Robert Kronstrand, Henrik Green, Moa Andresen Bergström   +4 more
wiley   +2 more sources

The Effect of Light Intensity and Polyethylene-Glycol-Induced Water Stress on the Growth, Mitragynine Accumulation, and Total Alkaloid Content of Kratom (Mitragyna speciosa)

Horticulturae
The cultivation of Mitragyna speciosa (kratom) has gained significant interest due to its diverse alkaloid profile, increasing its commercial and medicinal demand.
Nisa Leksungnoen, Tushar Andriyas, Yongkriat Ku-Or, Suthaporn Chongdi, Rossarin Tansawat, Attawan Aramrak, Chatchai Ngernsaengsaruay, Suwimon Uthairatsamee, Weerasin Sonjaroon, Phatthareeya Thongchot, Sirinapa Ardsiri, Pichaya Pongchaidacha   +11 more
doaj   +2 more sources

Mitragynine attenuates withdrawal syndrome in morphine-withdrawn zebrafish.

PLoS ONE, 2011
A major obstacle in treating drug addiction is the severity of opiate withdrawal syndrome, which can lead to unwanted relapse. Mitragynine is the major alkaloid compound found in leaves of Mitragyna speciosa, a plant widely used by opiate addicts to ...
Beng-Siang Khor, Mohd Fadzly Amar Jamil, Mohamad Ilham Adenan, Alexander Chong Shu-Chien   +3 more
doaj   +3 more sources

A review on multi-therapeutic potential of the Mitragyna speciosa (kratom) alkaloids mitragynine and 7-hydroxymitragynine: Experimental evidence and future perspectives

Kuwait Journal of Science
Mitragyna speciosa (kratom) is a traditional medicinal plant of Southeast Asia, known for its pharmacologically active alkaloids, mitragynine and 7-hydroxymitragynine.
Taslima Begum, M. Arzmi, Murni Nazira Sarian, S. A. Ali Shah, Syed Najmul Hejaz Azmi, A. Uddin, A. Khatib, Q. Ahmed   +7 more
doaj   +2 more sources

Discovery of rhynchophylline and mitraphylline in two Thai Mitragyna species and the investigation of their biological activity via opioid gene expression analysis [PDF]

Sci Rep
Mitragyna speciosa ( Ms ), M. diversifolia ( Md ), M. hirsuta ( Mh ) and M. rotundifolia ( Mr ) were investigated for phytochemicals by GC-MS and GC-FID, cytotoxicity and genotoxicity testing by MTT and comet assay, and biological activity examination ...
Ameamsri, Unchaleeporn, Chaveerach, Arunrat, Daduang, Sakda, Liehr, Thomas, Siripiyasing, Pornnarong, Sudmoon, Runglawan, Tanee, Tawatchai, Wonok, Warin   +7 more
core   +2 more sources

Methadone, Buprenorphine, and Clonidine Attenuate Mitragynine Withdrawal in Rats

Frontiers in Pharmacology, 2021
Background: Kratom or Mitragyna speciosa Korth has been widely used to relieve the severity of opioid withdrawal in natural settings. However, several studies have reported that kratom may by itself cause dependence following chronic consumption.
Rahimah Hassan, Sasidharan Sreenivasan, Christian P. Müller, Christian P. Müller, Zurina Hassan, Zurina Hassan   +5 more
doaj   +1 more source