Results 21 to 30 of about 2,942 (230)
In Vitro Pharmacology of Mitragynine at α-Adrenoceptors. [PDF]
ACS Chem NeurosciMitragynine is a psychoactive alkaloid in Mitragyna speciosa with unique polypharmacology at G protein-coupled receptors. In addition to its well-known partial agonist activity at opioid receptors, mitragynine is an antagonist at human α2A-adrenoceptors (
Chen Y +10 more
europepmc +2 more sources
EduChemia, 2023 Kratom leaves are known as traditional medicine with various benefits, such as antibacterial, antimicrobial, and antioxidant properties. These benefits are attributed to the presence of secondary metabolites, particularly mitragynine.
Syrifah Nur Intan Mutiara +4 more
doaj +1 more source
Directed Biosynthesis of Mitragynine Stereoisomers
Journal of the American Chemical Society, 2022 ABSTRACTMitragyna speciosa(“Kratom”) is used as a natural remedy for pain and management of opioid dependence. The pharmacological properties of Kratom have been linked to a complex mixture of monoterpene indole alkaloids, most notably mitragynine. Here, we report the central biosynthetic steps responsible for the scaffold formation of mitragynine and ...
Carsten Schotte +9 more
openaire +3 more sources
The cellular toxicology of mitragynine, the dominant alkaloid of the narcotic-like herb, Mitragyna speciosa Korth [PDF]
, 2015 Mitragyna speciosa Korth (Kratom), a herb of the Rubiaceae family is indigenous in southeast Asia mainly in Malaysia and Thailand. It is used as an opium substitute and has been increasingly abused by drug addicts in Malaysia.
Gooderham, NJ +3 more
core +5 more sources
Frontiers in Pharmacology, 2022 Adolescence is a critical developmental period during which exposure to psychoactive substances like kratom (Mitragyna speciosa) can cause long-lasting deleterious effects.
Aiman Nadhirah Zul Aznal +7 more
doaj +1 more source
The Chemical and Pharmacological Properties of Mitragynine and Its Diastereomers: An Insight Review
Frontiers in Pharmacology, 2022 Mitragynine, is a naturally occurring indole alkaloid that can be isolated from the leaves of a psychoactive medicinal plant. Mitragyna speciosa, also known as kratom, is found to possess promising analgesic effects on mediating the opioid receptors such
Thiruventhan Karunakaran +6 more
doaj +1 more source
Total Synthesis and Structural Plasticity of Kratom Pseudoindoxyl Metabolites**
Angewandte Chemie, Volume 135, Issue 35, August 28, 2023., 2023 Although opioids have been used in the treatment of pain for centuries, they cause various adverse effects and addiction. Recently, kratom alkaloids emerged as promising analgesic alternatives for pain management with considerably fewer side effects. The first scalable total synthesis of mitragynine pseudoindoxyl, the most potent atypical opioid kratom
Péter Angyal +9 more
wiley +2 more sources
Evaluation of the cardiotoxicity of mitragynine and its analogues using human induced pluripotent stem cell-derived cardiomyocytes. [PDF]
PLoS ONE, 2014 INTRODUCTION:Mitragynine is a major bioactive compound of Kratom, which is derived from the leave extracts of Mitragyna speciosa Korth or Mitragyna speciosa (M. speciosa), a medicinal plant from South East Asia used legally in many countries as stimulant
Jun Lu +7 more
doaj +1 more source
Frontiers in Pharmacology, 2021 Kratom is a widely abused plant-based drug preparation with a global interest in recent years, well beyond its native grounds in Southeast Asia. Mitragynine, its major psychoactive constituent is known to exhibit opioid-like behavioral effects with ...
Ismail Nurul Iman +10 more
doaj +1 more source
Separations, 2022 Mitragynine and its congeners are one of the major phytoconstituents present in Mitragyna speciosa Korth. (ketum) leaves and a well-known factor that contributes to ketum’s pharmacological activities.
Thiruventhan Karunakaran +5 more
doaj +1 more source