Results 51 to 60 of about 2,942 (230)

Changing Trends in the Use of Kratom (Mitragyna speciosa) in Southeast Asia [PDF]

, 2017
This is the pre-peer reviewed version of the following article: Darshan Singh, Suresh Narayanan, Balasingam Vicknasingam, Ornella Corazza, Rita Santacroce, and Andres Roman-Urrestarazu, ‘Changing trends in the use of kratom (Mitragyna speciosa) in ...
Corazza, Ornella, Narayanan, S, Roman-Urrestarazu, Andres, Santacroce, Rita, Singh, D, Vicknasingam, B   +5 more
core   +2 more sources

Pharmacokinetics of mitragynine in man

Drug Design, Development and Therapy, 2015
Kratom, known botanically as Mitragyna speciosa (Korth.), is an indigenous tree in Southeast Asia. Kratom is currently easily available worldwide via special shops and the Internet to use as a drug of abuse, opioid alternative, or pain killer. So far, the pharmacokinetics of this plant has been studied only in animals, and there is no such study in ...
Wananukul, Winai, Trakulsrichai,Satariya, Sathirakul,Korbtham, Auparakkitanon,Saranya, Krongvorakul,Jatupon, Sueajai,Jetjamnong, Noumjad,Nantida, Limsila,Penkhae   +7 more
openaire   +5 more sources

Two Single-Drug Fatal Intoxications by Mitragynine

Journal of Analytical Toxicology, 2022
Abstract Mitragyna speciosa, a species of plant that is native to Thailand, Malaysia and Southeast Asia, contains two major psychoactive alkaloids: mitragynine and 7-hydroxymitragynine. Pharmacologically, the alkaloids exhibit biphasic effects—at low doses, stimulant effects are realized, while high doses exhibit sedative effects.
George S Behonick, Christina Vu, Larry Czarnecki, Maisie El-Ters, Kevin G Shanks   +4 more
openaire   +2 more sources

Mitragyna Species as Pharmacological Agents: From Abuse to Promising Pharmaceutical Products

Life, 2022
Mitragyna is a genus belonging to the Rubiaceae family and is a plant endemic to Asia and Africa. Traditionally, the plants of this genus were used by local people to treat some diseases from generation to generation.
Islamudin Ahmad, Wisnu Cahyo Prabowo, Muhammad Arifuddin, Jaka Fadraersada, Niken Indriyanti, Herman Herman, Reza Yuridian Purwoko, Firzan Nainu, Anton Rahmadi, Swandari Paramita, Hadi Kuncoro, Nur Mita, Angga Cipta Narsa, Fajar Prasetya, Arsyik Ibrahim, Laode Rijai, Gemini Alam, Abdul Mun’im, Sukanya Dej-adisai   +18 more
doaj   +1 more source

Antidepressant-like effect of mitragynine isolated from Mitragyna speciosa Korth in mice model of depression. [PDF]

, 2011
Mitragyna speciosa Korth. leaves have been used for decades as a traditional medicine to treat diarrhea, diabetes and to improve blood circulation by natives of Malaysia, Thailand and other regions of Southeast Asia.
Abdul Rahman, Shamima, Adib Ridzuan, Nurul Raudzah, Apryani, Evhy, Baharuldin, Mohamad Taufik Hidayat, Fakurazi, Sharida, Mohd Moklas, Mohamad Aris, Nasir, Farah Idayu   +6 more
core   +1 more source

Nature's first “atypical opioids”: Kratom and mitragynines [PDF]

Journal of Clinical Pharmacy and Therapeutics, 2018
Advances in pain research have led to an understanding that many pains are driven by more than one underlying (patho)physiologic cause (ie, they are "multimechanistic") and that better pain relief is obtained with fewer adverse effects when an analgesic is correspondingly multimechanistic.
R. B. Raffa, J. V. Pergolizzi, R. Taylor, M. H. Ossipov   +3 more
openaire   +2 more sources

Testing the Efficacy of a Prototype That Combines Ultrasound and Pulsed Electric Field for Extracting Valuable Compounds from Mitragyna speciosa Leaves

AgriEngineering, 2023
This work aimed to test the efficacy of an ultrasound (US) and pulsed electric field (PEF) apparatus to extract mitragynine from dried Mitragyna speciosa cv. Karn Dang leaves. Four modes of the device were tested: PEF, US, US + PEF, and PEF + US, and the
Raweeroj Jintawiwat, Natnakorn Punamorntarakul, Rossakornpat Hirunyasiri, Parkpoom Jarupoom, Tanachai Pankasemsuk, Supakiat Supasin, Arthitaya Kawee-ai   +6 more
doaj   +1 more source

Effects of mitragynine from Mitragyna speciosa Korth leaves on working memory [PDF]

, 2010
Aim of the study: Mitragyna speciosa Korth from Rubiaceae family is a tropical plant indigenous to Southeast Asia particularly in Thailand, Peninsular of Malaysia and Indonesia. The leaves have been used by natives for their opium-like effect and cocaine-
Apryani, Evhy, Baharuldin, Mohamad Taufik Hidayat, Fakurazi, Sharida, Mohd Moklas, Mohamad Aris, Nasir, Farah Idayu   +4 more
core   +1 more source

Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit beta-Arrestin-2. [PDF]

, 2016
Natural products found in Mitragyna speciosa, commonly known as kratom, represent diverse scaffolds (indole, indolenine, and spiro pseudoindoxyl) with opioid activity, providing opportunities to better understand opioid pharmacology.
Borics, Attila, Marrone, Gina F., Narayan, Ankita, Palmer, Travis C., Szabó, Márton Richárd, Váradi, András   +5 more
core   +1 more source

Urine Screening for Opiod and Illicit Drugs in the Total Joint Arthroplasty Population [PDF]

, 2020
Introduction. Recent studies have shown an increase in post-operative orthopaedic complications associated with pre-operative opioid use. It is, therefore, important to know if patients use opioids before scheduled surgery.
Bhargava, Tarun, Messamore, William, Schmanke, Ken, Trent, Jesse, Vopat, Matthew, Yang, Shang-You, Zackula, Rosey   +6 more
core   +2 more sources