Results 61 to 70 of about 2,942 (230)
Frontiers in Psychiatry, 2020 BackgroundOpiate addiction is a major health problem in many countries. A crucial component of the medical treatment is the management of highly aversive opiate withdrawal signs, which may otherwise lead to resumption of drug taking.
Rahimah Hassan +6 more
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Molecules, 2023 Kratom (Mitragyna speciosa Korth. Havil) has been considered a narcotic drug for years, barred by the law in many parts of the world, while extensive research over the past few decades proves its several beneficial effects, some of which are still in ...
Rahni Hossain +6 more
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SODAS: Surveillance of Drugs of Abuse Study [PDF]
, 2017 Objective: Novel Psychoactive Substance (NPS) as a form of recreational drug use has become increasingly popular. There is a paucity of information with regards the prevalence and clinical sequalae of these drugs.
Bloeck, Felix +4 more
core +1 more source
Frontiers in Pharmacology, 2021 Mitragyna speciosa (“kratom”), employed as a traditional medicine to improve mood and relieve pain, has shown increased use in Europe and North America.
Shoshana Buckhalter +12 more
doaj +1 more source
Arab Journal of Forensic Sciences & Forensic Medicine, 2019 Kratom is a tropical tree indigenous to South East Asian countries and has been traditionally used by natives to increase work efficiency and treat selected illnesses.
Atty. Severino P. Uy +5 more
doaj +1 more source
Mitragynine inhibits hippocampus neuroplasticity and its molecular mechanism
Pharmacological Reports, 2023 Abstract Background Mitragynine (MIT), the primary indole alkaloid of kratom (Mitragyna speciosa), has been associated with addictive and cognitive decline potentials. In acute studies, MIT decreases spatial memory and inhibits hippocampal synaptic transmission in long-term potentiation (LTP). This study investigated the
Suleiman Yunusa +2 more
openaire +3 more sources
The Scientific World Journal, 2013 This study aimed to determine the effects of different concentrations and combinations of the phytohormones 2,4-dichlorophenoxy acetic acid (2,4-D), kinetin, 6-benzylaminopurine (BAP), and 1-naphthaleneacetic acid (NAA) on callus induction ...
Nor Nahazima Mohamad Zuldin +5 more
doaj +1 more source
Case Report: Treatment of Kratom Use Disorder With a Classical Tricyclic Antidepressant
Frontiers in Psychiatry, 2021 Kratom or Mitragyna speciosa (Korth.) is an evergreen tree of the coffee family native to South-East Asia and Australasia. It is used by locals recreationally to induce stimulant and sedative effects and medically to soothe pain and opiate withdrawal ...
Alessandro E. Vento +8 more
doaj +1 more source
Pharmacokinetics and Safety of Mitragynine in Beagle Dogs
Planta Medica, 2020 AbstractMitragynine is the most abundant psychoactive alkaloid derived from the leaves of Mitragyna speciosa (kratom), a tropical plant indigenous to regions of Southeast Asia. Mitragynine displays a moderate affinity to opioid receptors, and kratom is often self-prescribed to treat pain and/or opioid addiction.
Elizabeth A. Maxwell +9 more
openaire +3 more sources
Enhancement of Endothelial Barrier Permeability by Mitragynine
Biological & Pharmaceutical Bulletin, 2017 Persistent inhalation of mitragynine (MG), a major alkaloid in the leaves of Mitragyna speciosa, causes various systemic adverse effects such as seizure, diarrhea and arthralgias, but its toxicity to endothelial cells and effects on barrier function of the cells are poorly understood.
Toshiyuki, Matsunaga +10 more
openaire +3 more sources