Results 71 to 80 of about 2,942 (230)

Studies on the phase I and II metabolism and the toxicological analysis of the alkaloids of the herbal drug of abuse Mitragyna speciosa Korth. (Kratom) using gas chromatography-mass spectrometry and liquid chromatography coupled to low- and high-resolution linear ion trap mass spectrometry [PDF]

, 2011
In the presented studies, the herbal drug Kratom (Mitragyna speciosa) was investigated regarding its metabolism and its toxicological analysis in rat and human urine.
Philipp, Anika-Anina
core  

A Drug Toxicity Death Involving Propylhexedrine and Mitragynine* [PDF]

Journal of Analytical Toxicology, 2011
A death involving abuse of propylhexedrine and mitragynine is reported. Propylhexedrine is a potent α-adrenergic sympathomimetic amine found in nasal decongestant inhalers. The decedent was found dead in his living quarters with no signs of physical trauma.
Justin M, Holler, Shawn P, Vorce, Pamela C, McDonough-Bender, Joseph, Magluilo, Carol J, Solomon, Barry, Levine   +5 more
openaire   +2 more sources

The 730 nm Picosecond Titanium Sapphire Laser for Treatment of Kratom‐Induced Hyperpigmentation

Lasers in Surgery and Medicine, Volume 57, Issue 5, Page 373-382, July 2025.
ABSTRACT Objectives This case series reports the use of the 730‐nm picosecond titanium‐sapphire laser in the treatment of kratom‐induced hyperpigmentation, a dermatological side effect associated with the use of Mitragyna speciosa, which remains poorly understood. Methods A series of patients with kratom‐induced hyperpigmentation were treated using the
Alanoud A. Alhadyani, Christen Samaan, Girish S. Munavalli   +2 more
wiley   +1 more source

Accelerated Solvent Extractions (ASE) of Mitragyna speciosa Korth. (Kratom) Leaves: Evaluation of Its Cytotoxicity and Antinociceptive Activity

Molecules, 2021
Mitragyna speciosa Korth (kratom) is known for its psychoactive and analgesic properties. Mitragynine is the primary constituent present in kratom leaves.
Yong Sean Goh, Thiruventhan Karunakaran, Vikneswaran Murugaiyah, Rameshkumar Santhanam, Mohamad Hafizi Abu Bakar, Surash Ramanathan   +5 more
doaj   +1 more source

Copper‐Catalyzed Synthesis of C‐2 Substituted Indolin‐3‐Ones and Indolin‐3‐One [4+2] Cycloadducts Through Azide‐Tethered Iodonium Ylides

Asian Journal of Organic Chemistry, Volume 14, Issue 5, May 2025.
Azide‐tethered iodonium ylides under copper catalysis generate metallocarbenes that undergo intramolecular trapping by the azide moiety and generate a reactive C‐acylimine, effectively coupling two nucleophilic centers. This intermediate can be trapped by a wide range of nucleophiles or 1,3‐dienes producing complex indolin‐3‐ones and ...
Israel Najar Guerrero, Zinah Al‐Khateeb, F. G. West   +2 more
wiley   +1 more source

Sedative, cognitive impairment and anxiolytic effects of acute Mitragyna speciosa in rodents [PDF]

, 2013
Mitragyna speciosa, a plant from Rubiaceae family, was reported to have an opium-like effect and their coca-like stimulative ability to combat fatigue and enhance tolerance to hard work.
Adzhar, Muhammad Farhan, Amom, Zulkhairi, Baharuldin, Mohamad Taufik Hidayat, Fakurazi, Sharida, Mat Taib, Che Norma, Md Akim, Abdah, Md Rasul, Mohd Saifuddin, Mohd Moklas, Mohamad Aris, Muhamamd Yusof, Muhammad Khairulasraf, Suliman, Noor Azuin, Zakaria, Fatin Nadzirah   +10 more
core   +1 more source

Psychoactive Substances of Natural Origin: Toxicological Aspects, Therapeutic Properties and Analysis in Biological Samples [PDF]

, 2021
The consumption of new psychoactive substances (NPSs) has been increasing, and this problem affects several countries worldwide. There is a class of NPSs of natural origin, consisting of plants and fungi, which have a wide range of alkaloids, responsible
Duarte, Ana Paula, Gallardo, Eugenia, Gonçalves, Joana, Luís, Ângelo   +3 more
core   +1 more source

Biased Opioid Ligands

Molecules, 2020
Achieving effective pain management is one of the major challenges associated with modern day medicine. Opioids, such as morphine, have been the reference treatment for moderate to severe acute pain not excluding chronic pain modalities.
Abdelfattah Faouzi, Balazs R. Varga, Susruta Majumdar   +2 more
doaj   +1 more source

"Spice", "Kryptonite", "Black Mamba": An overview of brand names and marketing stragtegies of Novel Psychoactive Substances on the Web [PDF]

, 2014
Novel Psychoactive Substances (NPSs) are often sold online as “legal” and “safer” alternatives to International Controlled Drugs (ICDs) with captivating marketing strategies.
Advisory Council on the Misuse of Drugs (ACMD), Bersani F.S., Bigdeli I., Bruno R., Corazza O., Corazza O., Drug Enforcement Administration, Department of Justice, Evans-Brown M., Lesiak A.D., Musshoff F., United Nations Office on Drugs and Crime (UNODC)   +10 more
core   +2 more sources

Development and validation of a quantitative method for the analysis of delta‐9‐tetrahydrocannabinol (delta‐9‐THC), delta‐8‐tetrahydrocannabinol (delta‐8‐THC), delta‐9‐tetrahydrocannabinolic acid (THCA), and cannabidiol (CBD) in botanicals, edibles, liquids, oils, waxes, and bath products by gas chromatography mass spectrometry (GC/MS)

Journal of Forensic Sciences, Volume 69, Issue 5, Page 1718-1729, September 2024.
Abstract A quantitative gas chromatography mass spectrometry (GC/MS) method was developed for delta‐9‐tetrahydrocannabinol (delta‐9‐THC), delta‐8‐tetrahydrocannabinol (delta‐8‐THC), tetrahydrocannabinolic acid (THCA), and cannabidiol (CBD) in matrices including plant material, liquids and oils, waxes, edibles, and bath and body products.
Sarah A. Shuda, Joshua F. Folger, Erin Spargo, Barry K. Logan   +3 more
wiley   +1 more source