Results 1 to 10 of about 15,125 (218)

Cytotoxicity of crystals involves RIPK3-MLKL-mediated necroptosis [PDF]

Nature Communications, 2016
AbstractCrystals cause injury in numerous disorders, and induce inflammation via the NLRP3 inflammasome, however, it remains unclear how crystals induce cell death. Here we report that crystals of calcium oxalate, monosodium urate, calcium pyrophosphate dihydrate and cystine trigger caspase-independent cell death in five different cell types, which is ...
Shrikant R Mulay, Jyaysi Desai, Santhosh V R Kumar   +2 more
exaly   +9 more sources

The MLKL kinase-like domain dimerization is an indispensable step of mammalian MLKL activation in necroptosis signaling [PDF]

Cell Death and Disease, 2021
MLKL phosphorylation by RIP3 is the commitment step of necroptosis execution, which could induce MLKL activation featured as MLKL monomer-oligomer transition.
Yu Zhang, Jia Liu, Dandan Yu, Xinxin Zhu, Xiaoyan Liu, Jun Liao, Sheng Li, Huayi Wang   +7 more
doaj   +3 more sources

MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis

Nature Communications, 2020
Mixed lineage kinase domain-like (MLKL) is the terminal protein in the pro-inflammatory necroptotic cell death program. Here the authors show that MLKL trafficking and plasma membrane accumulation are crucial necroptosis checkpoints, and that ...
Andre L Samson, Katherine A Davies, Michael J Mlodzianoski   +2 more
exaly   +2 more sources

Treatment with mRNA coding for the necroptosis mediator MLKL induces antitumor immunity directed against neo-epitopes [PDF]

Nature Communications, 2018
Cancer immunotherapy can induce durable antitumor responses. However, many patients poorly respond to such therapies. Here we describe a generic antitumor therapy that is based on the intratumor delivery of mRNA that codes for the necroptosis executioner
Lien Van Hoecke, Sandra Van Lint, Kenny Roose   +2 more
exaly   +4 more sources

Adipocyte-specific Mlkl knockout mitigates obesity-induced metabolic dysfunction by enhancing mitochondrial functions [PDF]

Cell Death and Disease
Obesity is a global epidemic characterized by chronic low-grade inflammation and metabolic dysfunction, with adipose tissue playing a pivotal role in these processes.
Juliette Tokgozoglu, Valeria Pistorio, Mirko Minini, Pierre-Antoine Soret, Virginie Steunou, Jean-Louis Delaunay, Julien Castel, Serge Luquet, Ivan Nemazanyy, Carine Beaupère, Laetitia Dinard, Tatiana Ledent, Aurore L’honoré, Sara Lemoinne, Chantal Housset, Philippe Lesnik, Vlad Ratziu, Bruno Fève, Tounsia Aït-Slimane, Axelle Cadoret, Nicolas Chignard, Jérémie Gautheron   +21 more
doaj   +2 more sources

Methamphetamine Exposure Induces Neuronal Programmed Necrosis by Permeabilizing Mitochondria via the RIPK1–RIPK3–MLKL Axis [PDF]

Toxics
Methamphetamine (Meth), a psychostimulant drug of the amphetamine type, is widely abused and highly neurotoxic. Meth exposure leads to neuronal necroptosis, and the mitochondrial dysfunction may be involved.
Peng Zhou, Jiankang Xuan, Weixiao Xu, Di An, Sining Meng, Hongchao Zhang, Miaoyang Hu, Wanqingyang Hui, Yifei Wang, Jie Cheng, Jianping Xiong, Jun Wang, Xufeng Chen   +12 more
doaj   +2 more sources

Necroptosis: A Novel Pathway in Neuroinflammation

Frontiers in Pharmacology, 2021
Neuroinflammation is a complex inflammatory process in the nervous system that is expected to play a significant role in neurological diseases. Necroptosis is a kind of necrosis that triggers innate immune responses by rupturing dead cells and releasing ...
Ziyu Yu, Nan Jiang, Nan Jiang, Wenru Su, Yehong Zhuo   +4 more
doaj   +1 more source

Necroptosis in Pulmonary Diseases: A New Therapeutic Target

Frontiers in Pharmacology, 2021
In the past decades, apoptosis has been the most well-studied regulated cell death (RCD) that has essential functions in tissue homeostasis throughout life.
Lingling Wang, Ling Zhou, Yuhao Zhou, Lu Liu, Weiling Jiang, Huojun Zhang, Huiguo Liu   +6 more
doaj   +1 more source

Evidence for developmental vascular-associated necroptosis and its contribution to venous-lymphatic endothelial differentiation

Frontiers in Cell and Developmental Biology, 2023
During development, apoptosis removes redundant cells and ensures proper organ morphogenesis. Necrosis is long known as an adult-bound inflammatory and pathologic cell death.
Han Meng, Youyi Zhao, Yuqian Li, Hong Fan, Xuyang Yi, Xinyu Meng, Pengfei Wang, Fanfan Fu, Shengxi Wu, Yazhou Wang   +9 more
doaj   +1 more source

Dynamics of necroptosis in kidney ischemia-reperfusion injury

Frontiers in Immunology, 2023
Necroptosis, a pathway of regulated necrosis, involves recruitment and activation of RIPK1, RIPK3 and MLKL, leading to cell membrane rupture, cell death and release of intracellular contents causing further injury and inflammation.
Aspasia Pefanis, Aspasia Pefanis, Aspasia Pefanis, Anjan K. Bongoni, Jennifer L. McRae, Evelyn J. Salvaris, Nella Fisicaro, James M. Murphy, James M. Murphy, James M. Murphy, Francesco L. Ierino, Francesco L. Ierino, Peter J. Cowan, Peter J. Cowan   +13 more
doaj   +1 more source