Results 121 to 130 of about 15,125 (218)
Frontiers in PharmacologyMixed lineage kinase domain-like protein (MLKL) is a pseudokinase featured by a protein kinase-like domain without catalytic activity. MLKL was originally discovered to be phosphorylated by receptor-interacting protein kinase 1/3, typically increase ...
Yang Wang +5 more
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Bilinear quark operator renormalization at generalized symmetric point
, 2016 We compute Green's functions with a bilinear quark operator inserted at non-zero momentum for a generalized momentum configuration to two loops. These are required to assist lattice gauge theory measurements of the same quantity in matching to the high ...
Bell, J. M., Gracey, J. A.
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Investigation of the molecular mechanism used by the necroptosis pathway to suppress apoptosis [PDF]
, 2016 细胞凋亡和细胞坏死是最主要的两种细胞程序性死亡方式，在个体生长发育、内环境稳态维持以及众多生理和病理过程中发挥着重要作用。由于细胞坏死和细胞凋亡具有截然不同的特征，它们会造成截然不同的生物学结果，因此，细胞死亡方式的选择受到极其严密的调控。这两种死亡方式不是相互孤立的，而是存在着相互联系、相互竞争的关系，在特定的条件下还可以相互转化。大量遗传学的证据表明，细胞凋亡可以抑制细胞坏死，这对胚胎的正常发育至关重要；然而人们对于细胞坏死如何抑制细胞凋亡却一无所知。 肿瘤坏死因子（TNF ...
杨章华
core
MLKL activity requires a splicing-regulated, druggable intramolecular interaction
Molecular CellNecroptosis is an inflammatory form of regulated cell death implicated in a range of human pathologies, whose execution depends on the poorly understood pseudokinase mixed lineage kinase domain-like (MLKL). Here, we report that splicing-dependent insertion of a short amino acid sequence in the C-terminal α-helix (Hc) of MLKL abolishes cell killing ...
Ros, U. ; https://orcid.org/0000-0002-3609-3988 +30 more
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Označevanje aktivne oblike MLKL
, 2020 Nekroptoza je ena izmed oblik programirane nekroze, pri kateri ima ključno vlogo protein MLKL (ang. mixed lineage kinase-domain like), ki ob aktivaciji oligomerizira, se vgradi v plazmalemo in povzroči sprostitev celične vsebine. V signalni poti imajo pomembno vlogo tudi drugi nekroptotični proteini, predvsem kinazi RIPK1 in RIPK3. Nekroptoza nastopi v
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Molecular mechanisms of cell death induced by matrine in human cholangiocarcinoma Cells [PDF]
, 2016 胆管癌是起源于胆管上皮的一种恶性肿瘤，在我国发病率和死亡率逐年上升。而胆管癌细胞抵抗凋亡是导致胆管癌化疗失败的重要原因，所以研发能够诱导胆管癌细胞以不发生凋亡的死亡新途径的化疗药显得十分重要。苦参碱具有多途径、多种机制的抗肿瘤活性，已经证实能够诱导多种肿瘤细胞死亡，但是在胆管癌中的生物学作用和潜在机制却鲜有报道。程序性坏死(necroptosis)是可被调控的程序性细胞死亡，在形态学上具有典型的坏死样形态改变，依赖于受体相互作用蛋白1和3，此外，可被程序性坏死的特异性抑制剂Nec-1所阻断 ...
徐贝贝
core
Cell Communication and SignalingPurpose Cardiomyocyte death is a major cytopathologic response in acute myocardial infarction (AMI) and involves complex inflammatory interactions. Although existing reports indicating that mixed lineage kinase domain-like protein (MLKL) is involved in ...
Lijiang Wei +11 more
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On Braided Linear Gr-categories [PDF]
, 2014 We provide explicit and unified formulae for the normalized 3-cocycles on arbitrary finite abelian groups. As an application, we compute all the braided monoidal structures on linear Gr-categories.Comment: 14 pages; typos ...
Huang, Hua-Lin, Liu, Gongxiang, Ye, Yu
core
MLKL‒OPTN axis regulates herpesvirus‐induced neurological sequelae
Clinical and Translational MedicineBackground Herpes simplex virus‐1 (HSV‐1) infections are lifelong and linked to neurological diseases such as multiple sclerosis (MS), yet the underlying mechanisms in the host remain poorly understood.
Ilina Bhattacharya +9 more
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Ecotoxicology and Environmental SafetyT-2 toxin is one of the most potent and commonly occurring secondary metabolites of type A trichothecene mycotoxins. Although it has been associated with cardiomyocyte necrosis, the underlying mechanisms of T-2 toxin-induced myocardial injury ...
Xinhe Zhang +9 more
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