Results 131 to 140 of about 15,502 (223)

On Braided Linear Gr-categories [PDF]

, 2014
We provide explicit and unified formulae for the normalized 3-cocycles on arbitrary finite abelian groups. As an application, we compute all the braided monoidal structures on linear Gr-categories.Comment: 14 pages; typos ...
Huang, Hua-Lin, Liu, Gongxiang, Ye, Yu
core  

Methamphetamine Exposure Induces Neuronal Programmed Necrosis by Permeabilizing Mitochondria via the RIPK1–RIPK3–MLKL Axis

Toxics
Methamphetamine (Meth), a psychostimulant drug of the amphetamine type, is widely abused and highly neurotoxic. Meth exposure leads to neuronal necroptosis, and the mitochondrial dysfunction may be involved.
Peng Zhou, Jiankang Xuan, Weixiao Xu, Di An, Sining Meng, Hongchao Zhang, Miaoyang Hu, Wanqingyang Hui, Yifei Wang, Jie Cheng, Jianping Xiong, Jun Wang, Xufeng Chen   +12 more
doaj   +1 more source

Adipocyte-specific Mlkl knockout mitigates obesity-induced metabolic dysfunction by enhancing mitochondrial functions

Cell Death and Disease
Obesity is a global epidemic characterized by chronic low-grade inflammation and metabolic dysfunction, with adipose tissue playing a pivotal role in these processes.
Juliette Tokgozoglu, Valeria Pistorio, Mirko Minini, Pierre-Antoine Soret, Virginie Steunou, Jean-Louis Delaunay, Julien Castel, Serge Luquet, Ivan Nemazanyy, Carine Beaupère, Laetitia Dinard, Tatiana Ledent, Aurore L’honoré, Sara Lemoinne, Chantal Housset, Philippe Lesnik, Vlad Ratziu, Bruno Fève, Tounsia Aït-Slimane, Axelle Cadoret, Nicolas Chignard, Jérémie Gautheron   +21 more
doaj   +1 more source

Nucleic acid sensors and programmed cell death [PDF]

, 2020
Liverpool, Layal, Maelfait, Jonathan, Rehwinkel, Jan   +2 more
core   +2 more sources

MLKL‒OPTN axis regulates herpesvirus‐induced neurological sequelae

Clinical and Translational Medicine
Background Herpes simplex virus‐1 (HSV‐1) infections are lifelong and linked to neurological diseases such as multiple sclerosis (MS), yet the underlying mechanisms in the host remain poorly understood.
Ilina Bhattacharya, Rashmi Kadam, Tejabhiram Yadavalli, Chandrashekhar D. Patil, Hemant Borase, Ipsita Volety, Sergey Kalinin, Douglas L. Feinstein, Henry C. Tseng, Deepak Shukla   +9 more
doaj   +1 more source

Saracatinib inhibits necroptosis and ameliorates psoriatic inflammation by targeting MLKL

Cell Death & Disease
AbstractNecroptosis is a kind of programmed cell death that causes the release of damage-associated molecular patterns and inflammatory disease including skin inflammation. Activation of receptor-interacting serine/threonine kinase 1 (RIPK1), RIPK3, and mixed lineage kinase domain-like protein (MLKL) is the hallmark of tumour necrosis factor α (TNF ...
Jingyi Li, Xingfeng Liu, Yuanyuan Liu, Fangmin Huang, Jiankun Liang, Yingying Lin, Fen Hu, Jianting Feng, Zeteng Han, Yushi Chen, Xuan Chen, Qiaofa Lin, Lanqin Wu, Lisheng Li   +13 more
openaire   +3 more sources

LUBAC-mediated M1 Ub regulates necroptosis by segregating the cellular distribution of active MLKL

Cell Death and Disease
Plasma membrane accumulation of phosphorylated mixed lineage kinase domain-like (MLKL) is a hallmark of necroptosis, leading to membrane rupture and inflammatory cell death.
Nadine Weinelt, Kaja Nicole Wächtershäuser, Gulustan Celik, Birte Jeiler, Isabelle Gollin, Laura Zein, Sonja Smith, Geoffroy Andrieux, Tonmoy Das, Jens Roedig, Leonard Feist, Björn Rotter, Melanie Boerries, Francesco Pampaloni, Sjoerd J. L. van Wijk   +14 more
doaj   +1 more source

Necroptosis of Glycolytic Dendritic Cells Enhances Activation of Gamma Delta T Cells [PDF]

, 2016
Gamma delta (gd) T lymphocytes are a poorly understood class of immune cells that accumulate at sites of inflammation due to infection or autoimmunity. Part of the mystery of this T cell subset derives from lack of knowledge of ligands that bind to the T
Bashant, Kathleen R
core   +1 more source

MLKL wt Allele [PDF]

, 2020
openaire   +1 more source

ROS via promoting RIP1 auto-phosphorylation to enhance TNF-induced necrosome formation and subsequent necroptosis [PDF]

, 2015
活性氧（ReactiveOxygenSpecies，ROS）的产生存在于生物体的众多生理病理过程中。大量的实验数据表明，活性氧还参与到了细胞凋亡和程序性坏死的进程里。丁基羟基苯甲醚（Butylatedhydroxyanisole，BHA）是公认的活性氧清除剂，异戊巴比妥（Amytal）是线粒体上电子传递到泛醌的抑制剂，二者都曾被广泛报道，可以抑制或者延缓肿瘤坏死因子（TumorNecroticFactorα，TNF-α）诱导的小鼠成纤维细胞系L929的程序性细胞坏死。然而 ...
张荧荧
core