Results 11 to 20 of about 15,125 (218)

HSP70 promotes MLKL polymerization and necroptosis [PDF]

Molecular & Cellular Oncology, 2020
Mixed lineage kinase domain-like protein (MLKL) is the proposed executioner of necroptosis. Our recent findings identify a novel inhibitor necroptosis-blocking compound 1 (NBC1) which specifically conjugates to two cysteines of heat shock protein 70 ...
Andrea N. Johnston, Zhigao Wang
doaj   +3 more sources

Interferons Transcriptionally Up-Regulate MLKL Expression in Cancer Cells

Neoplasia: An International Journal for Oncology Research, 2019
Interferons (IFNs) are key players in the tumor immune response and act by inducing the expression of IFN-stimulated genes (ISGs). Here, we identify the mixed-lineage kinase domain-like pseudokinase (MLKL) as an ISG in various cancer cell lines.
Anne-Kathrin Knuth, Stefanie Rösler, Barbara Schenk, Lisa Kowald, Sjoerd J.L. van Wijk, Simone Fulda   +5 more
doaj   +5 more sources

MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates

Cell Reports, 2014
Although mixed lineage kinase domain-like (MLKL) protein has emerged as a specific and crucial protein for necroptosis induction, how MLKL transduces the death signal remains poorly understood.
Yves Dondelinger, Wim Declercq, Sylvie Montessuit, Ria Roelandt, Amanda Goncalves, Inge Bruggeman, Paco Hulpiau, Kathrin Weber, Clark A. Sehon, Robert W. Marquis, John Bertin, Peter J. Gough, Savvas Savvides, Jean-Claude Martinou, Mathieu J.M. Bertrand, Peter Vandenabeele   +15 more
doaj   +4 more sources

Endothelial MLKL Inhibition Reduces Hyperoxia-Induced Bronchopulmonary Dysplasia in Neonatal Mice. [PDF]

J Cell Mol Med
ABSTRACT Bronchopulmonary dysplasia (BPD) remains a severe complication in premature infants requiring prolonged oxygen therapy, with vascular endothelial dysfunction recognised as a critical contributor to disease progression. Mixed lineage kinase domain‐like protein (MLKL)‐mediated necroptosis, an essential form of regulated cell death implicated in ...
Ning J, Deng J, Sang Y, Qiao L.
europepmc   +2 more sources

Oligomerization‐driven MLKL ubiquitylation antagonizes necroptosis [PDF]

The EMBO Journal, 2021
AbstractMixed lineage kinase domain‐like (MLKL) is the executioner in the caspase‐independent form of programmed cell death called necroptosis. Receptor‐interacting serine/threonine protein kinase 3 (RIPK3) phosphorylates MLKL, triggering MLKL oligomerization, membrane translocation and membrane disruption.
Zikou Liu, Laura F. Dagley, Kristy Shield-Artin, Samuel N. Young, Aleksandra Bankovacki, Xiangyi Wang, Michelle Tang, Jason Howitt, Che A. Stafford, Ueli Nachbur, Cheree Fitzgibbon, Sarah E. Garnish, Andrew I. Webb, David Komander, James M. Murphy, Joanne M. Hildebrand, John Silke   +16 more
openaire   +3 more sources

The molecular mechanisms of MLKL-dependent and MLKL-independent necrosis [PDF]

Journal of Molecular Cell Biology, 2020
AbstractNecrosis, a type of unwanted and passive cell demise, usually occurs under the excessive external stress and is considered to be unregulated. However, under some special conditions such as caspase inhibition, necrosis is regulable in a well-orchestrated way.
Li, Lu, Tong, An, Zhang, Qiangsheng, Wei, Yuquan, Wei, Xiawei   +4 more
openaire   +2 more sources

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source

Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis

Hepatology, EarlyView., 2022
EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu, Xiude Fan, Megan R. McMullen, Tatsunori Miyata, Adam Kim, Vai Pathak, Jianguo Wu, Le Z. Day, Josiah E. Hardesty, Nicole Welch, Jaividhya Dasarathy, Daniela S. Allende, Arthur J. McCullough, Jon M. Jacobs, Daniel M. Rotroff, Srinivasan Dasarathy, Laura E. Nagy   +16 more
wiley   +1 more source

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

Hepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso, Tawhidul Islam, Julie Magusto, Ricardo Amorim, Véronique Lenoir, Rui F. Simões, José Teixeira, Liana C. Silva, Dominique Wendum, Isabelle Jéru, Corinne Vigouroux, Rui E. Castro, Paulo J. Oliveira, Carina Prip‐Buus, Vlad Ratziu, Jérémie Gautheron, Cecília M. P. Rodrigues   +16 more
wiley   +1 more source

Quercetin'in HT-29 ve HCT-116 kolon kanseri hücre hatları üzerine etkisinin RIPK1, RIPK3 ve MLKL genlerinin ekspresyonları ile incelenmesi

Adıyaman Üniversitesi Sağlık Bilimleri Dergisi, 2023
Amaç: Quercetin kolon kanseri dahil birçok kanser çeşidinde anti-kanser aktivite gösteren bir bileşiktir. Ancak, quercetinin nekroptoz yolağı üzerine etkilerini gösteren çalışmalar kısıtlıdır ve bu nedenle bu çalışmada quercetinin nekroptoz yolağına ...
Haydar Bağış, Esra Bozgeyik, Alp Can Tuncer, Sevval Has   +3 more
doaj   +1 more source