Results 81 to 90 of about 15,125 (218)

Respiratory Syncytial Virus (RSV): A Comprehensive Overview From Basic Biology to Clinical Prevention and Control

Medicinal Research Reviews, EarlyView.
ABSTRACT Respiratory syncytial virus (RSV) is a common virus that causes respiratory infections, posing a serious threat, particularly to infants, the elderly, and individuals with compromised immune systems. As the leading cause of lower respiratory tract infections (LRTIs) in infants, RSV is responsible for millions of cases worldwide each year.
Jie Shi, Xiya Huang, Chunjun Ye, Yishan Lu, Yanyan Liu, Yuquan Wei, Xiawei Wei   +6 more
wiley   +1 more source

Deciphering diverse cell‐death patterns to predict the prognosis and potential therapy target of hepatocellular carcinoma patients

VIEW, EarlyView.
Abstract Ninety percent of all primary liver malignancies are hepatocellular carcinomas (HCC), making liver cancer the third most common cause of cancer‐associated mortality. Different patterns of programmed cell death (PCD) are crucial for the survival of tumors, and they might serve as a prognostic marker for HCC.
Lin Ding, Qian Li, Wenjing Yang, Te Liu, Tongtong Tian, Yu Liu, Chunyan Zhang, Baishen Pan, Beili Wang, Fan Wu, Wei Guo   +10 more
wiley   +1 more source

Increased MLKL mRNA level in the PBMCs is correlated with autoantibody production, renal involvement, and SLE disease activity

Arthritis Research & Therapy, 2020
Background Necroptosis is a form of regulated necrosis that is involved in various autoimmune diseases. Mixed lineage kinase domain-like pseudokinase (MLKL) has been identified as a key executor of necroptosis; however, the significance of MLKL in ...
Mingjiao Zhang, Hongyu Jie, Yong Wu, Xinai Han, Xing Li, Yi He, Xingliang Shi, Yuwei Luo, Ying Sun, Jinlong Yang, Jing Yang, Shulv Quan, Xiaobin Lao, Liping Tan, Erwei Sun   +14 more
doaj   +1 more source

On the growth of Lebesgue constants for convex polyhedra

, 2018
In the paper, new estimates of the Lebesgue constant $$ \mathcal{L}(W)=\frac1{(2\pi)^d}\int_{\mathbb{T}^d}\bigg|\sum_{{k}\in W\cap \mathbb{Z}^d} e^{i({k},\,{x})}\bigg| {\rm d}{ x} $$ for convex polyhedra $W\subset\mathbb{R}^d$ are obtained.
Kolomoitsev, Yurii, Lomako, Tetiana
core   +1 more source

ZFP36 stabilizes RIP1 via degradation of XIAP and cIAP2 thereby promoting ripoptosome assembly [PDF]

, 2015
BACKGROUND: ZFP36 is an mRNA binding protein that exerts anti-tumor activity in glioblastoma by triggering cell death, associated to an increase in the stability of the kinase RIP1. METHODS: We used cell death assays, size exclusion chromatography,
ALECCI, CLAUDIA, Dell' Aquila, Miriam, FERRARI, Sergio, GRANDE, Alexis, Guizzetti, Filippo, MARTELLO, Andrea, MONTORSI, LUCIA, PARENTI, Sandra, Salomoni, Paolo, SELMI, TOMMASO, VOLPI, Nicola, ZANOCCO MARANI, Tommaso   +11 more
core   +1 more source

The TAT-RasGAP317-326 anti-cancer peptide can kill in a caspase-, apoptosis-, and necroptosis-independent manner. [PDF]

, 2016
Tumor cell resistance to apoptosis, which is triggered by many anti-tumor therapies, remains a major clinical problem. Therefore, development of more efficient therapies is a priority to improve cancer prognosis.
Barras, D., Chevalier, N., Heulot, M., Kreis, S., Kulms, D., Margue, C., Michel, S., Nahimana, A., Puyal, J., Widmann, C.   +9 more
core   +1 more source

The relationship between the cannabinoids and cardiac remodelling: A comprehensive review of pivotal mechanisms and emerging evidence

British Journal of Pharmacology, EarlyView.
Cardiac remodelling and fibrosis after myocardial infarction or during chronic diseases, such as arterial and pulmonary hypertension or diabetes mellitus, continue to be the more important prognostic factors in determining survival, and so the search for effective anti‐fibrotic interventions is an important target for research and therapy in cardiology.
Anna Krzyżewska, Marta Baranowska‐Kuczko, Hanna Kozłowska   +2 more
wiley   +1 more source

Necroptosis induced by RIPK3 requires MLKL but not Drp1 [PDF]

Cell Death & Disease, 2014
Necroptosis is a mechanism by which cells can kill themselves that does not require caspase activity or the presence of the pro-apoptotic Bcl-2 family members Bax or Bak. It has been reported that RIPK3 (receptor interacting protein kinase 3) activates MLKL (mixed lineage kinase domain-like) to cause cell death that requires dynamin-related protein 1 ...
Moujalled, DM, Cook, WD, Murphy, JM, Vaux, DL   +3 more
openaire   +3 more sources

MLKL-Driven Inflammasome Activation and Caspase-8 Mediate Inflammatory Cell Death in Influenza A Virus Infection

mBio, 2023
Influenza A virus (IAV) triggers multiple programmed cell death pathways, including MLKL-dependent necroptosis, caspase-8-dependent apoptosis, and caspase-1-dependent pyroptosis in myeloid cells.
Xuqiu Lei, Yongzhi Chen, Egil Lien, Katherine A. Fitzgerald   +3 more
doaj   +1 more source

Role of RIPK1/RIPK3/MLKL signalling pathway in sepsis‐associated acute kidney injury

Experimental Physiology, EarlyView.
Abstract Sepsis‐associated acute kidney injury (SA‐AKI) is a common clinical syndrome in critically ill patients, and its high mortality rate is closely related to complex pathological mechanisms. Existing studies have shown that the pathophysiological process of SA‐AKI involves complex multi‐mechanism interactions, including an uncontrolled systemic ...
Huijun Yin, Jingyi Wang, Huirong Han
wiley   +1 more source