本研究目的主要是以芋頭(Taro)作爲發酵基質進行固態培養,利用紅麴菌(Monascus spp.)進行發酵,培養過程中藉控制溫度、pH 值、加水量等條件,並期望提高 monacolin K 生成量。同時比較 Monascus pilosus BCRC 31527、Monascus ruber BCRC 31535等兩株菌株次級代謝物(secondary metabolites) monacolin K、citrinin、紅麴色素的生成、抗氧化能力及多酚類等物質,探討不同培養條件 ...
鄭金坤, Cheng, Jin-Kun
core
Randomized, Double-Blind, Placebo-Controlled Trial to Test the Effects of a Nutraceutical Combination Monacolin K-Free on the Lipid and Inflammatory Profile of Subjects with Hypercholesterolemia. [PDF]
Protic O +11 more
europepmc +1 more source
Production of Monacolin K in Monascus pilosus: Comparison between Industrial Strains and Analysis of Its Gene Clusters. [PDF]
Dai W, Shao Y, Chen F.
europepmc +1 more source
Biosynthesis of ML-236B (compactin) and monacolin K.
A, Endo +4 more
openaire +3 more sources
Beneficial Metabolic Effect of a Nutraceuticals Combination (Monacolin K, Yeasted Red Rice, Polyphenolic Extract of Annurca Apple and Berberine) on Acquired Hypercholesterolemia: A Prospective Analysis. [PDF]
D'Assante R +15 more
europepmc +1 more source
The synthesis of compactin (ML-236B) and monacolin K in fungi.
A, Endo +4 more
openaire +3 more sources
Honeysuckle as a Bio-Enhancer in <i>Monascus purpureus</i> Fermentation: Synergistic Improvement of Monacolin K Yield and Flavor Complexity. [PDF]
Ablimit A +10 more
europepmc +1 more source
Effects of Chinese medicines on monacolin K production and related genes transcription of Monascus ruber in red mold rice fermentation. [PDF]
Peng L +5 more
europepmc +1 more source
Polyketide 為自然之結構多樣性化合物,是微生物所產生之二次代謝物,大部分由真菌及絲狀細菌所產生,具有釵h的生理活性,包括抗生素或真菌毒素。其負責合成之酵素 polyketide synthase (PKS) 十分類似脂肪酸合成酶 (fatty acid synthase, FAS)。PKS 與 FAS 不同的是其可允雩鼮L或增加某些還原及脫水反應,而可產生釵h結構多樣性之化合物。Monacolin K (lovastatin) 為一種 polyketide,是膽固醇生合成之關鍵酵素 HMG ...
Huang, Wen-Nin, 黃玟寧
core

