Genomic Redistribution of Metal-Response Transcription Factor-1 (MTF-1) in Cadmium Resistant Cells [PDF]
Cells, 2023 (1) Background: Metal homeostasis is an important part of cellular programs and is disrupted when cells are exposed to carcinogenic heavy metals. Metal response is mediated by the metal response element transcription factor MTF-1.
Gregory M. Wright, Joshua C. Black
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Ferroptosis-related gene MTF-1 as a novel prognostic biomarker in low-grade glioma and its correlation with immune infiltration [PDF]
Heliyon, 2023 Background: Metal-responsive transcription factor-1 performs a necessary position in a range of cancers. It is unknown, though, how the prognosis of patients with low-grade gliomas is related to immune infiltration.
Huaixu Li +5 more
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Gawky modulates MTF-1-mediated transcription activation and metal discrimination. [PDF]
Nucleic Acids Res, 2021 Abstract Metal-induced genes are usually transcribed at relatively low levels under normal conditions and are rapidly activated by heavy metal stress. Many of these genes respond preferentially to specific metal-stressed conditions. However, the mechanism by which the general transcription machinery discriminates metal stress from normal
Jia R +5 more
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The hypoxia sensitive metal transcription factor MTF-1 activates NCX1 brain promoter and participates in remote postconditioning neuroprotection in stroke [PDF]
Cell Death and Disease, 2021 Remote limb ischemic postconditioning (RLIP) is an experimental strategy in which short femoral artery ischemia reduces brain damage induced by a previous harmful ischemic insult.
Valeria Valsecchi +6 more
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Inhibition of endogenous MTF-1 signaling in zebrafish embryos identifies novel roles for MTF-1 in development. [PDF]
Biochim Biophys Acta, 2014 The metal responsive element-binding transcription factor-1 (MTF-1) responds to changes in cellular zinc levels caused by zinc exposure or disruption of endogenous zinc homeostasis by heavy metals or oxygen-related stress. Here we report the functional characterization of a complete zebrafish MTF-1 in comparison with the previously identified isoform ...
O'Shields B +5 more
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ANALISIS ALGORITMA MTF, MTF-1 DAN MTF-2 PADA BURROWS WHEELER COMPRESSION ALGORITHM
JUTEI (Jurnal Terapan Teknologi Informasi), 2019 Kebutuhan kompresi data teks di era komputasi awan saat ini masih cukup tinggi. Data teks perlu dikompresi sekecil mungkin agar mudah dikirimkan. Burrows Wheeler Compression Algorithm (BWCA) adalah salah satu algoritma kompresi teks jenis block sorting ...
Sagara Mahardika Sunaryo +2 more
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Target gene search for the metal-responsive transcription factor MTF-1 [PDF]
Nucleic Acids Research, 2001 Activation of genes by heavy metals, notably zinc, cadmium and copper, depends on MTF-1, a unique zinc finger transcription factor conserved from insects to human. Knockout of MTF-1 in the mouse results in embryonic lethality due to liver decay, while knockout of its best characterized target genes, the stress-inducible metallothionein genes I and II ...
Ragna Sack
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The taste of heavy metals: Gene regulation by MTF-1
Biochimica Et Biophysica Acta - Molecular Cell Research, 2012 The metal-responsive transcription factor-1 (MTF-1, also termed MRE-binding transcription factor-1 or metal regulatory transcription factor-1) is a pluripotent transcriptional regulator involved in cellular adaptation to various stress conditions, primarily exposure to heavy metals but also to hypoxia or oxidative stress.
Walter Schaffner
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A T > G Mutation in the NR5A2 Gene Is Associated With Litter Size in Hu Sheep Through Upregulation of Promoter Activity by Transcription Factor MTF-1 [PDF]
Frontiers in Genetics, 2019 Nuclear receptor subfamily 5 group A member 2 (NR5A2), also referred to as LRH-1 or FTF, is an orphan nuclear hormone receptor that is involved in regulating embryonic development, ovarian granulosa cell differentiation, gonadal sex differentiation, and ...
Yinxia Li +13 more
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Embryonic lethality and liver degeneration in mice lacking the metal-responsive transcriptional activator MTF-1 [PDF]
EMBO Journal, 1998 We have shown previously that the heavy metal-responsive transcriptional activator MTF-1 regulates the basal and heavy metal-induced expression of metallothioneins. To investigate the physiological function of MTF-1, we generated null mutant mice by targeted gene disruption. Embryos lacking MTF-1 die in utero at approximately day 14 of gestation.
Rainer L Heuchel
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