Results 241 to 250 of about 75,068 (344)

mTOR Kinase Domain Phosphorylation Promotes mTORC1 Signaling, Cell Growth, and Cell Cycle Progression

, 2011
Bilgen Ekim, Brian Magnuson, Hugo A. Acosta-Jaquez, Jennifer A. Keller, Edward P. Feener, Diane C. Fingar   +5 more
openalex   +1 more source

Rapamycin Reverses Elevated mTORC1 Signaling in Lamin A/C–Deficient Mice, Rescues Cardiac and Skeletal Muscle Function, and Extends Survival [PDF]

, 2012
Fresnida J. Ramos, Steven C. Chen, Michael G. Garelick, Dao‐Fu Dai, Chen-Yu Liao, Katherine H. Schreiber, Vivian L. MacKay, Elroy H. An, Randy Strong, Warren Ladiges, Peter S. Rabinovitch, Matt Kaeberlein, Brian K. Kennedy   +12 more
openalex   +1 more source

Triggering mTORC1 in T cells [PDF]

Nature Immunology, 2014
openaire   +2 more sources

Local Growth Hormone Facilitates Aging of the Colon Epithelial Microenvironment

Aging Cell, EarlyView.
Local growth hormone (GH) is expressed and secreted by senescent cells in the aging human colon. GH triggers epithelial‐to‐mesenchymal transition and activates colon cell motility by regulating extracellular matrix proteins, inducing cytoskeleton rearrangement and altering cell motility protein phosphorylation.
Vera Chesnokova, Svetlana Zonis, Richard Ainsworth, Tugce Apaydin, Christian Wong Valencia, Elora C. Greiner, Robert Barrett, Arminja N. Kettenbach, Shlomo Melmed   +8 more
wiley   +1 more source

LINC00622 transcriptionally promotes RRAGD to repress mTORC1-modulated autophagic cell death by associating with BTF3 in cutaneous melanoma. [PDF]

Cell Death Dis
Li C, Wang K, Zhao L, Liu J, Jin Y, Zhang C, Xu M, Wang M, Kuang Y, Liu J, Zhou L, Wen Q.   +11 more
europepmc   +1 more source

PI3K-Akt-mTORC1-S6K1/2 Axis Controls Th17 Differentiation by Regulating Gfi1 Expression and Nuclear Translocation of RORγ [PDF]

, 2012
Yutaka Kurebayashi, Shigenori Nagai, Ai Ikejiri, Masashi Ohtani, Kenji Ichiyama, Yukiko Baba, Taketo Yamada, Shohei Egami, Takayuki Hoshii, Atsushi Hirao, Satoshi Matsuda, Shigeo Koyasu   +11 more
openalex   +1 more source

Superoxide Activates Ferroptosis via the Haber‐Weiss Reaction and Enhances Age‐Related Macular Degeneration

Aging Cell, EarlyView.
Superoxide activates ferroptosis through the Haber‐Weiss reaction and contributes to the development of age‐related macular degeneration. MnSOD‐depleted RPE cells are susceptible to blue light‐induced ferroptosis. MnSOD deficiency promotes Hsp70‐driven ubiquitin‐mediated degradation of GPX4.
Ying Huang, Zhenxing Zhou, Mengjia Huan, Qi Guo, Xiaoqian Zhang, Ruiqi Lu, Lushu Chen, Xiumiao Li, Jin Yao, Qin Jiang, Yong Xu   +10 more
wiley   +1 more source

A bitopic mTORC inhibitor reverses phenotypes in a tuberous sclerosis complex model. [PDF]

Sci Rep
Mukherjee S, Wolan MJ, Scott MK, Riley VA, Sokolov AM, Feliciano DM.   +5 more
europepmc   +1 more source

Dual mTORC1/2 and HER2 Blockade Results in Antitumor Activity in Preclinical Models of Breast Cancer Resistant to Anti-HER2 Therapy [PDF]

, 2012
Celina García-García, Yasir H. Ibrahim, Violeta Serra, María Teresa Calvo, Marta Guzmán, Judit Grueso, Claudia Aura, Jose Pérez, Katti Jessen, Yi Liu, Christian Rommel, Josep Tabernero, José Baselga, Maurizio Scaltriti   +13 more
openalex   +1 more source

BLOC1S1 Control of Vacuolar Organelle Fidelity Modulates Murine TH2 Cell Immunity and Allergy Susceptibility

Allergy, EarlyView.
Abbreviations: BLOC1S1, biogenesis of lysosome organelles complex 1 subunit 1; cGAS, cyclic GMP‐AMP synthase; GATA3, GATA binding protein 3; IgE, immunoglobulin E; IKK, inhibitor of nuclear factor kappa‐B kinase; IL, interleukin; mtDNA, mitochondrial DNA; NF‐κB, nuclear factor‐kappa B; OVA, ovalbumin; MC903, vitamin D3 analog; STING, stimulator of ...
Rahul Sharma, Kaiyuan Wu, Kim Han, Anna Chiara Russo, Pradeep K. Dagur, Christian A. Combs, Xianglan Yao, Stewart J. Levine, Michael N. Sack   +8 more
wiley   +1 more source