Results 251 to 260 of about 75,068 (344)

Microbial trash to metabolic treasure. [PDF]

Immunometabolism (Cobham)
Dowdell AS, Colgan SP.
europepmc   +1 more source

The nuclear receptor TR3 regulates mTORC1 signaling in lung cancer cells expressing wild-type p53

, 2011
Syng‐Ook Lee, T Andey, U-H Jin, Kyounghyun Kim, Mandip Sachdeva, Stephen Safe   +5 more
openalex   +1 more source

Metformin inhibition of mTORC1 activation, DNA synthesis and proliferation in pancreatic cancer cells: Dependence on glucose concentration and role of AMPK [PDF]

, 2012
James Sinnett‐Smith, Krisztina Kisfalvi, Róbert Kui, Enrique Rozengurt   +3 more
openalex   +1 more source

Non‐Allergic Urticarial Skin Reactions Associated With MOv18 IgE, a First‐In‐Class IgE Antibody Recognising Folate Receptor Alpha

Allergy, EarlyView.
MOv18 IgE, the first‐in‐class IgE antibody targeting the cancer antigen folate receptor alpha (FR⍺) showed early signs of efficacy and was well tolerated in a first‐in‐human clinical trial, with transient urticarial skin reactions as the most common toxicity.
Chara Stavraka, Jitesh Chauhan, Silvia Crescioli, Sheila M. McSweeney, Amy Pope, Cheryl Gillett, Ashley Di Meo, Ioannis Prassas, Roman Laddach, Katie Stoker, Alexandra J. McCraw, Rebecca Adams, Thomas J. Tull, Nabeel Naban, Zena Willsmore, Kristina V. Semkova, Clive E. H. Grattan, John McGrath, Stephen J. Till, Christopher J. Corrigan, Rebecca Kristeleit, Sophia Tsoka, Eleftherios P. Diamandis, Katie E. Lacy, Sarah Pinder, Debra H. Josephs, James Spicer, Heather J. Bax, Sophia N. Karagiannis   +28 more
wiley   +1 more source

Correction: Delta opioid receptor agonists activate PI3K-mTORC1 signaling in parvalbumin-positive interneurons in mouse infralimbic prefrontal cortex to exert acute antidepressant-like effects. [PDF]

Mol Psychiatry
Yoshioka T, Yamada D, Hagiwara A, Kajino K, Iio K, Saitoh T, Nagase H, Saitoh A.   +7 more
europepmc   +1 more source

Psychedelics, entactogens and psychoplastogens for depression and related disorders

British Journal of Pharmacology, EarlyView.
Currently, the most actively investigated rapidly acting antidepressants, anxiolytics and/or anti PTSD agents, include psychedelics e.g. psilocybin, LSD, N,N‐dimethyltryptamine, ayahuasca; non‐hallucinogenic entactogens, e.g. MDMA; psychoplastogens which rapidly promote neuroplasticity, e.g.
Daniel Hoyer
wiley   +1 more source

ATR promotes mTORC1 activity via de novo cholesterol synthesis. [PDF]

EMBO Rep
Tangudu NK, Grumet AN, Fang R, Buj R, Cole AR, Uboveja A, Amalric A, Yang B, Huang Z, Happe C, Sun M, Gelhaus SL, MacDonald ML, Hempel N, Snyder NW, Kedziora KM, Valvezan AJ, Aird KM.   +17 more
europepmc   +1 more source

Pharmacological and Genetic Evaluation of Proposed Roles of Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase Kinase (MEK), Extracellular Signal-regulated Kinase (ERK), and p90RSK in the Control of mTORC1 Protein Signaling by Phorbol Esters

, 2011
Bruno D. Fonseca, Tommy Alain, Leona K. Finestone, Brandon Huang, Mark Rolfe, Tian Jiang, Zhong Yao, Greco Hernández, Christopher F. Bennett, Christopher G. Proud   +9 more
openalex   +1 more source

Elevated MTORC1 signaling and impaired autophagy [PDF]

, 2012
Fresnida J. Ramos, Matt Kaeberlein, Brian K. Kennedy   +2 more
openalex   +1 more source

475 mTORC1

Journal of Animal Science, 2018
M Guesthier, J Huang, X Zhao, S Burgos
openaire   +2 more sources