Results 251 to 260 of about 108,192 (330)
International Journal of Cancer, Volume 158, Issue 3, Page 475-487, 1 February 2026.Abstract Hepatocellular carcinoma (HCC) represents the predominant form of primary liver cancer and is frequently identified at a late stage, necessitating systemic therapy. However, resistance to first‐line tyrosine kinase inhibitor therapies, such as sorafenib and lenvatinib, remains a significant clinical challenge.
Longtao Zhao +6 more
wiley +1 more source
New cell lines expanding the diversity of Ewing sarcoma models
International Journal of Cancer, Volume 158, Issue 3, Page 642-655, 1 February 2026.What's new? A chromosomal translocation between the EWSR1 and ETS genes is the key oncogenic driver in Ewing sarcoma. EWSR1::FLI1, the most frequent fusion, is subdivided into different fusion types with unclear prognostic relevance. Here, the authors describe the establishment and characterization of four new, intrinsically immortal, patient‐derived ...
Maximilian Kerkhoff +13 more
wiley +1 more source
Rheb1 signaling and the fate of pancreatic β cells: Toward a new frontier in diabetes therapy. [PDF]
World J DiabetesKarimkhani H.
europepmc +1 more source
Alterations in Gut Microbiota and Metabolic Profiles in Relapsed or Refractory Lymphoma
MicrobiologyOpen, Volume 15, Issue 1, February 2026.Metabolomic volcano‐heatmap reveals seven upregulated metabolites in relapsed/refractory lymphoma, underscoring gut metabolic reprogramming as a potential therapeutic target. ABSTRACT To identify potential therapeutic strategies for relapsed or refractory lymphoma (R/RL) by examining differences in gut microbiota composition and metabolic profiles ...
Yu‐Ying Guo +5 more
wiley +1 more source
mTORC1 signaling in group 2 innate lymphoid cells coordinates neuro-immune crosstalk in allergic lung inflammation. [PDF]
Nat CommunWang D +12 more
europepmc +1 more source
MedComm, Volume 7, Issue 2, February 2026.Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo +11 more
wiley +1 more source
Growth factor-independent mTORC1 signaling promotes primary cilia length via suppression of autophagy. [PDF]
iScienceShin J +9 more
europepmc +1 more source
Ventilator‐Induced Lung Injury: Mechanotransduction and Potential Therapeutic Targets
MedComm, Volume 7, Issue 2, February 2026.Mechanical ventilation (MV) is expected to undergo significant transformative advancements by 2050, with the emergence of personalized ventilation systems that promise to revolutionize respiratory care. However, the risk of ventilator‐induced lung injury (VILI) remains a significant concern at this stage and VILI still exists at that time.
He Ren +4 more
wiley +1 more source
MicroRNA-mediated metabolic disruption as an emerging driver of alcohol use disorder. [PDF]
Nat CommunMcArdle CJ, Raab-Graham KF.
europepmc +1 more source