Results 251 to 260 of about 102,812 (293)

Dysregulation of Farnesoid X Receptor on Neutrophil Homeostasis Exacerbates Intestinal Inflammation via the mTORC1-Glycolysis Signaling Pathway. [PDF]

MedComm (2020)
Kang D, Li A, Xie X, Liu H, Chen L, Feng Z, Gao X, Gao H, Wu X, Lu H, Li X, Hua J, Ju L, Lian H, Li X, Liu Z.   +15 more
europepmc   +1 more source

Synergistic antiviral activity against human adenovirus through combination of itraconazole and brincidofovir

British Journal of Pharmacology, Volume 183, Issue 7, Page 1578-1601, April 2026.
Background and Purpose Human adenovirus (HAdV) causes respiratory or gastrointestinal tract infections depending on the virus subtype. While HAdV infections are generally self‐limiting in immunocompetent people, they can result in significant morbidity and mortality in immunocompromised adults and children.
Mohamed Zamzamy, Sophie Post, Wing Hang Ip, Elin Hahlin, Sebastian Kühn, Andrea Pirosu, Christian Conze, Martin Baumdick, Hamburg Intestinal Study Group, Madeleine J. Bunders, Britta F. Zecher, Angelique Hoelzemer, Stephan Linder, Niklas Arnberg, Thomas Dobner, Marcus Altfeld, Sebastian Schloer   +16 more
wiley   +1 more source

Metabolic reprogramming in neurodegenerative diseases: New insights into mTOR-mediated microglial polarization. [PDF]

J Transl Int Med
Song W, Zhang Y, Xu T, Fan T, Li J, Liu M, Wei W, Pei X, Li R.   +8 more
europepmc   +1 more source

Does Time Tick Faster in Cerebral Palsy? Accelerated Aging as a Framework for Skeletal Muscle Dysfunction

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Skeletal muscle in individuals with cerebral palsy (CP) may undergo accelerated aging through mechanisms shared with age‐related sarcopenia. Representative overlapping molecular and cellular features include, for example, neuromuscular alterations, impaired satellite cell function and niche composition, chronic inflammation, metabolic deficits, reduced
Oscar Horwath, Sebastian Edman, Sudarshan Dayanidhi, Davis Englund, Mark D. Peterson, Ferdinand von Walden   +5 more
wiley   +1 more source

Metabolic reprogramming in cancer: dysregulation of glucose, lipid, and amino acid pathways and therapeutic opportunities. [PDF]

Mol Biomed
Yu M, Yang D, Chen X, Yang Y, Zhang B, Jiang X, Xing L, Yang Y, Sun Y, Li N.   +9 more
europepmc   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, Volume 16, Issue 3, Page 570-583, March 2026.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Nutrients and Metabolites as Signalling Molecules in Osteoclasts. [PDF]

Curr Osteoporos Rep
Chandrasekaran K, Hu S, Farstad-O'Halloran K, Iyer KS, Jiang H, Pavlos N, Chen K.   +6 more
europepmc   +1 more source

A Smart Bio‐Battery Facilitates Diabetic Bone Defect Repair Via Inducing Macrophage Reprogramming and Synergistically Modulating Bone Remodeling Coupling

Advanced Functional Materials, Volume 36, Issue 24, 23 March 2026.
This research presents a novel implantable bio‐battery, GF‐OsG, tailored for diabetic bone repair. GF‐OsG generates microcurrents in high‐glucose conditions to enhance vascularization, shift macrophages to the M2 phenotype, and regulate immune responses.
Nanning Lv, Haifu Sun, Wenxiang Tang, Yonggang Li, Zhonglai Qian, Lihui Hong, Chong Chen, Hongye Li, Jiaxiang Bai, Yusen Qiao, Mingming Liu   +10 more
wiley   +1 more source