Results 91 to 100 of about 71,509 (231)

Brain Cholinergic Mechanisms

Frontiers in Synaptic Neuroscience, 2015
Sukumar eVijayaraghavan, Geeta eSharma
doaj   +1 more source

Is muscarinic receptor agonist effective and tolerant for schizophrenia?

BMC Psychiatry
Background Several randomized clinical trials (RCTs) have recently examined the efficacy and tolerability of muscarinic receptor agonists in schizophrenia. However, whether therapeutics targeting muscarinic receptors improve symptom management and reduce
Xiaonan Guo, Rongshan Deng, Jianbo Lai, Shaohua Hu   +3 more
doaj   +1 more source

An Algorithm for the Diagnosis and Management of Severe Asthma in Children and Adolescents

Allergy, EarlyView.
Eckard Hamelmann, Bianca Schaub, Susanne Lau, Leonard B. Bacharier   +3 more
wiley   +1 more source

PAC‐FOS: A novel translational concordance framework identifies preclinical seizure models with highest predictive validity for clinical focal onset seizures

Epilepsia, EarlyView.
Abstract Objective Central to the development of novel antiseizure medications (ASMs) is testing of antiseizure activity in preclinical models. Although various well‐established models exist, their predictive validity across the spectrum of clinical epilepsies has been less clear.
Lyndsey L. Anderson, Kristopher M. Kahlig, Melissa L. Barker‐Haliski, Lillian G. Matthews, Hamish D. Toop, Brian Hannigan, Jacqueline French, H. Steve White, Marcio Souza, Steven Petrou   +9 more
wiley   +1 more source

Protection from interferon‐β‐induced neuronal apoptosis through stimulation of muscarinic acetylcholine receptors coupled to ERK1/2 activation [PDF]

, 2016
Maria C. Olianas, Simona Dedoni, Pierluigi Onali   +2 more
openalex   +1 more source

Respiratory dysfunction and fatal apnea during pilocarpine‐induced status epilepticus

Epilepsia, EarlyView.
Abstract Objective Status epilepticus (SE) is second only to sudden unexpected death in epilepsy as a cause of seizure‐related mortality. The progression of respiratory dysfunction during experimental SE remains poorly characterized. We investigated how pilocarpine‐induced SE affects respiration in mice.
Chengsan Sun, Rachel Spera, John M. Williamson, Suchitra Joshi, Bhavya Guduru, Harini Ganabady, Jaideep Kapur   +6 more
wiley   +1 more source

Two types of muscarinic response to acetylcholine in mammalian cortical neurons.

, 1985
David A. McCormick, David A. Prince
openalex   +2 more sources

Spreading depolarization and its influence on epileptiform activity

Epilepsia, EarlyView.
Abstract Spreading depolarization (SD) is a transient disruption of electrographic activity that slowly propagates through the gray matter by chemical contiguity, and it is characterized by a large depolarization of neurons and glial cells. SD, which is associated with massive changes in ion homeostasis, including extreme increases in [K+]o, was shown ...
Maxime Lévesque, Rüdiger Köhling, Massimo Avoli   +2 more
wiley   +1 more source

Management of an uncommon complication using botulinum toxin type A following prosthetic laryngoplasty

Equine Veterinary Education, EarlyView.
Summary An uncommon complication following prosthetic laryngoplasty was reported in a 4‐year‐old Andalusian mare. The mare was presented with a previously diagnosed left‐sided recurrent laryngeal neuropathy, after initial evaluation the mare underwent ventriculocordectomy and prosthetic laryngoplasty.
J. L. Sanclemente, D. S. Larriva, C. A. Ragle   +2 more
wiley   +1 more source

Activation of muscarinic receptors in PC12 cells. Correlation between cytosolic Ca2+ rise and phosphoinositide hydrolysis [PDF]

, 1986
L. Vicentini, A Ambrosini, Francesco Di Virgilio, Jacopo Meldolesi, Tullio Pozzan   +4 more
openalex   +1 more source