Results 11 to 20 of about 626,152 (307)

Myeloid Cells in Glioblastoma Microenvironment [PDF]

Cells, 2020
Glioblastoma (GBM) is the most aggressive, malignant primary brain tumor in adults. GBM is notoriously resistant to immunotherapy mainly due to its unique immune microenvironment. High dimensional data analysis reveals the extensive heterogeneity of immune components making up the GBM microenvironment.
Alessandra De Leo, Alessio Ugolini, Filippo Veglia   +2 more
openaire   +4 more sources

Ovarian cancer modulates the immunosuppressive function of CD11b+Gr1+ myeloid cells via glutamine metabolism

Molecular Metabolism, 2021
Objective: Immature CD11b + Gr1+ myeloid cells that acquire immunosuppressive capability, also known as myeloid-derived suppressor cells (MDSCs), are a heterogeneous population of cells that regulate immune responses.
Mary P. Udumula, Sharif Sakr, Sajad Dar, Ayesha B. Alvero, Rouba Ali-Fehmi, Eman Abdulfatah, Jing Li, Jun Jiang, Amy Tang, Thomas Buekers, Robert Morris, Adnan Munkarah, Shailendra Giri, Ramandeep Rattan   +13 more
doaj   +1 more source

Myeloid Derived Suppressor Cells in Chronic Myeloid Leukemia [PDF]

Frontiers in Oncology, 2015
The suppression of the immune system creates a permissive environment for development and progression of cancer. One population of immunosuppressive cells that have become the focus of intense study is myeloid derived suppressor cells (MDSCs), immature myeloid cells able to induce immune-escape, angiogenesis, and tumor progression.
Cesarina eGiallongo, Nunziatina eParrinello, Maria Violetta Brundo, Salvatore Antonino Raccuia, Salvatore Antonino Raccuia, Michelino eDi Rosa, Piera eLa Cava, Tibullo eDaniele   +7 more
openaire   +6 more sources

Donor Cell Myeloid Sarcoma [PDF]

Case Reports in Hematology, 2014
Donor cell derived malignancies are a rare and interesting complication of allogeneic bone marrow transplantation. We present a case of a 56-year-old male with donor cell myeloid sarcoma of the stomach and myocardium.
Mark A. Walshauser, Aileen Go, Payal Sojitra, Girish Venkataraman, Patrick Stiff   +4 more
openaire   +3 more sources

T cells contribute to tumor progression by favoring pro-tumoral properties of intra-tumoral myeloid cells in a mouse model for spontaneous melanoma. [PDF]

PLoS ONE, 2011
Tumors affect myelopoeisis and induce the expansion of myeloid cells with immunosuppressive activity. In the MT/ret model of spontaneous metastatic melanoma, myeloid cells are the most abundant tumor infiltrating hematopoietic population and their ...
Renée Lengagne, Arnaud Pommier, Jonathan Caron, Laetitia Douguet, Marylène Garcette, Masashi Kato, Marie-Françoise Avril, Jean-Pierre Abastado, Nadège Bercovici, Bruno Lucas, Armelle Prévost-Blondel   +10 more
doaj   +1 more source

HoxA9 binds and represses the Cebpa +8 kb enhancer [PDF]

, 2019
C/EBPα plays a key role in specifying myeloid lineage development. HoxA9 is expressed in myeloid progenitors, with its level diminishing during myeloid maturation, and HOXA9 is over-expressed in a majority of acute myeloid leukemia cases, including those
Aplan, Peter D., Dennison, Lauren, Friedman, Alan D., Guo, Hong, Hess, Jay L., Ma, Peilin, Peng, Lei, Sun, Yuqing   +7 more
core   +2 more sources

Junctional adhesion molecule-A is dispensable for myeloid cell recruitment and diversification in the tumor microenvironment

Frontiers in Immunology, 2022
Junctional adhesion molecule-A (JAM-A), expressed on the surface of myeloid cells, is required for extravasation at sites of inflammation and may also modulate myeloid cell activation.
Máté Kiss, Máté Kiss, Máté Kiss, Els Lebegge, Els Lebegge, Aleksandar Murgaski, Aleksandar Murgaski, Aleksandar Murgaski, Helena Van Damme, Helena Van Damme, Daliya Kancheva, Daliya Kancheva, Daliya Kancheva, Jan Brughmans, Jan Brughmans, Isabelle Scheyltjens, Isabelle Scheyltjens, Ali Talebi, Robin Maximilian Awad, Yvon Elkrim, Yvon Elkrim, Pauline M. R. Bardet, Pauline M. R. Bardet, Sana M. Arnouk, Sana M. Arnouk, Cleo Goyvaerts, Johan Swinnen, Frank Aboubakar Nana, Frank Aboubakar Nana, Jo A. Van Ginderachter, Jo A. Van Ginderachter, Damya Laoui, Damya Laoui   +32 more
doaj   +1 more source

MTSS1 is a critical epigenetically regulated tumor suppressor in CML [PDF]

, 2015
Chronic myeloid leukemia (CML) is driven by malignant stem cells that can persist despite therapy. We have identified Metastasis suppressor 1 (Mtss1/MIM) to be downregulated in hematopoietic stem and progenitor cells from leukemic transgenic SCLtTA/Bcr ...
Braunschweig, T., Brümmendorf, T. H., Chatain, N., Copland, M., Costa, I. G., Gusmao, E. G., Haenzelmann, S., Hamilton, A., Helgason, G.V., Herrmann, O., Holyoake, T. L., Kintsler, S., Koschmieder, S., Li, S., Merle Reher, M., Müller-Tidow, C., Schemionek, M., Schubert, C., Schwab, A.   +18 more
core   +1 more source

Evolution of Myeloid Cells [PDF]

Microbiology Spectrum, 2016
ABSTRACTIn 1882, Elie Metchnikoff identified myeloid-like cells from starfish larvae responding to the invasion by a foreign body (rose thorn). This marked the origins for the study of innate immunity, and an appreciation that cellular immunity was well established even in these “primitive” organisms. This chapter focuses on these myeloid cells as well
Daniel R, Barreda, Harold R, Neely, Martin F, Flajnik   +2 more
openaire   +2 more sources

Fludarabine as a cost-effective adjuvant to enhance engraftment of human normal and malignant hematopoiesis in immunodeficient mice [PDF]

, 2018
There is still an unmet need for xenotransplantation models that efficiently recapitulate normal and malignant human hematopoiesis. Indeed, there are a number of strategies to generate humanized mice and specific protocols, including techniques to ...
A Rambaldi, A Terenzi, AM Carroll, AM Carroll, BS Andersson, CR Giver, D Niederwieser, DA Frank, DE Mosier, E McCormack, F Aversa, IF Khouri, K Tajima, L Luznik, L Weiss, M Furukawa, NC Kirkiles-Smith, S Goyama   +17 more
core   +1 more source