Results 21 to 30 of about 626,152 (307)
Dendrogenin A drives LXR to trigger lethal autophagy in cancers
Nature Communications, 2017 Dendrogenin A, cholesterol metabolite, has tumor suppressive properties but the mechanisms are unknown. Here the authors show that Dendrogenin A can induce autophagy-mediated cell death in both melanoma and acute myeloid leukaemia.
Gregory Segala +34 more
doaj +1 more source
Cell Reports, 2015 We investigate crosstalk between cancer cells and stromal myeloid cells. We find that Lewis lung carcinoma cells significantly induce PPARβ/δ activity in myeloid cells in vitro and in vivo.
Jonghanne Park +12 more
doaj +1 more source
Myeloid-Derived Suppressor Cells [PDF]
Viral Immunology, 2017 AbstractMyeloid cells developed evolutionarily as a major mechanism to protect the host. They evolved as a critical barrier against infections and are important contributors to tissue remodeling. However, in cancer, myeloid cells are largely converted to serve a new master—tumor cells.
openaire +4 more sources
Tumor-reactive immune cells protect against metastatic tumor and induce immunoediting of indolent but not quiescent tumor cells [PDF]
, 2016 Two major barriers to cancer immunotherapy include tumor-induced immune suppression mediated by myeloid-derived suppressor cells and poor immunogenicity of the tumor-expressing self-antigens.
Bear, Harry D. +8 more
core +2 more sources
Myeloid Cells in Metastasis [PDF]
Cold Spring Harbor Perspectives in Medicine, 2019 Metastatic disease is the leading cause of death in patients with solid cancers. The progression to metastasis is a multistep process that involves detachment of tumor cells from their constraining basement membrane at the primary site, migration and intravasation into the circulation, survival in the circulation, extravasation into the secondary organ,
Agnieszka, Swierczak, Jeffrey W, Pollard
openaire +2 more sources
Direct sensing of systemic and nutritional signals by haematopoietic progenitors in Drosophila. [PDF]
, 2012 The Drosophila lymph gland is a haematopoietic organ in which progenitor cells, which are most akin to the common myeloid progenitor in mammals, proliferate and differentiate into three types of mature cell--plasmatocytes, crystal cells and lamellocytes--
Banerjee, Utpal +2 more
core +2 more sources
Myeloid-derived suppressor cells and their role in gynecological malignancies
Tumor Biology, 2018 Myeloid-derived suppressor cells are a heterogeneous population of immature myeloid cells that exhibit immunosuppressive activity (they block the proliferation and activity of both T cells and natural killer cells).
Seiji Mabuchi +3 more
doaj +1 more source
Antigen presenting capacity of murine splenic myeloid cells [PDF]
, 2017 BACKGROUND: The spleen is an important site for hematopoiesis. It supports development of myeloid cells from bone marrow-derived precursors entering from blood. Myeloid subsets in spleen are not well characterised although dendritic cell (DC) subsets are
Hey, Ying-Ying +2 more
core +2 more sources
FHL2 regulates hematopoietic stem cell functions under stress conditions. [PDF]
, 2015 FHL2, a member of the four and one half LIM domain protein family, is a critical transcriptional modulator. Here, we identify FHL2 as a critical regulator of hematopoietic stem cells (HSCs) that is essential for maintaining HSC self-renewal under ...
Chen, J +12 more
core +2 more sources
Role of Rip2 in development of tumor-infiltrating MDSCs and bladder cancer metastasis. [PDF]
, 2014 Tumor invasion and metastases represent a complex series of molecular events that portends a poor prognosis. The contribution of inflammatory pathways mediating this process is not well understood. Nod-like receptors (NLRs) of innate immunity function as
Chin, Arnold I, Zhang, Hanwei
core +6 more sources