Results 11 to 20 of about 126,969 (246)

Indoleamine 2,3-dioxygenase-expressing leukemic dendritic cells impair a leukemia-specific immune response by inducing potent T regulatory cells

Haematologica, 2010
Background The immunoregulatory enzyme indoleamine 2,3-dioxygenase, which catalyzes the conversion of tryptophan into kynurenine, is expressed in a significant subset of patients with acute myeloid leukemia, resulting in the inhibition of T-cell ...
Antonio Curti, Sara Trabanelli, Chiara Onofri, Michela Aluigi, Valentina Salvestrini, Darina Ocadlikova, Cecilia Evangelisti, Sergio Rutella, Raimondo De Cristofaro, Emanuela Ottaviani, Michele Baccarani, Roberto M. Lemoli   +11 more
doaj   +1 more source

Identification of Clec4b as a novel regulator of bystander activation of auto-reactive T cells and autoimmune disease.

PLoS Genetics, 2020
The control of chronic inflammation is dependent on the possibility of limiting bystander activation of autoreactive and potentially pathogenic T cells.
Liselotte Bäckdahl, Mike Aoun, Ulrika Norin, Rikard Holmdahl   +3 more
doaj   +1 more source

Twenty-four-color full spectrum flow cytometry panel for minimal residual disease detection in acute myeloid leukemia

Open Medicine, 2023
Full spectrum flow cytometry brings a breakthrough for minimal residual disease (MRD) detection in acute myeloid leukemia (AML). We aimed to explore the role of a new panel in MRD detection. We established a 24-color full-spectrum flow cytometry panel. A
Chen Man, Fu Minjing, Gong Meiwei, Gao Yajing, Wang Aixian, Zhao Wei, Wu Xueying, Wang Hui   +7 more
doaj   +1 more source

Lactotransferrin-Cre reporter mice trace neutrophils, monocytes/macrophages and distinct subtypes of dendritic cells

Haematologica, 2014
Considerable effort has been expended to identify genes that account for myeloid lineage commitment and development. However, currently available non-invasive mouse models utilize myeloid-specific reporters that are significantly expressed in ...
Boris Kovacic, Andrea Hoelbl-Kovacic, Katrin M. Fischhuber, Nicole R. Leitner, Dagmar Gotthardt, Emilio Casanova, Veronika Sexl, Mathias Müller   +7 more
doaj   +1 more source

SUBTYPE CHARACTERICS OF DENDRITIC CELLS FROM PERIPHERAL BLOOD OF PATIENTS WITH RHEUMATOID ARTHRITIS

Медицинская иммунология, 2014
. Characteristics of myeloid and plasmacytoid dendritic cells from peripheral blood were studied in healthy donors and patients with rheumatoid arthritis (RA).
S. A. Falaleeva, V. V. Kurilin, N. S. Shkaruba, O. A. Chumasova, A. E. Sizikov, S. V. Sennikov   +5 more
doaj   +1 more source

Vaginal Myeloid Dendritic Cells Transmit Founder HIV-1 [PDF]

Journal of Virology, 2014
ABSTRACT We report that primary human vaginal dendritic cells (DCs) display a myeloid phenotype and express CD4, CCR5, and CXCR4. Vaginal CD13 + CD11c + DCs rapidly and efficiently bound transmitted/founder (T/F) CCR5-tropic (R5) viruses, transported them through explanted vaginal ...
Ruizhong, Shen, John C, Kappes, Lesley E, Smythies, Holly E, Richter, Lea, Novak, Phillip D, Smith   +5 more
openaire   +2 more sources

Interaction of Rotavirus with Human Myeloid Dendritic Cells [PDF]

Journal of Virology, 2005
ABSTRACTWe have previously shown that very few rotavirus (RV)-specific T cells that secrete gamma interferon circulate in recently infected and seropositive adults and children. Here, we have studied the interaction of RV with myeloid immature (IDC) and mature dendritic cells (MDC) in vitro.
Carlos F, Narváez, Juana, Angel, Manuel A, Franco   +2 more
openaire   +2 more sources

Inflammation rapidly recruits mammalian GMP and MDP from bone marrow into regional lymphatics

eLife, 2021
Innate immune cellular effectors are actively consumed during systemic inflammation, but the systemic traffic and the mechanisms that support their replenishment remain unknown.
Juana Serrano-Lopez, Shailaja Hegde, Sachin Kumar, Josefina Serrano, Jing Fang, Ashley M Wellendorf, Paul A Roche, Yamileth Rangel, Leolene J Carrington, Hartmut Geiger, H Leighton Grimes, Sanjiv Luther, Ivan Maillard, Joaquin Sanchez-Garcia, Daniel T Starczynowski, Jose A Cancelas   +15 more
doaj   +1 more source

Bone marrow plasmacytoid dendritic cells can differentiate into myeloid dendritic cells upon virus infection [PDF]

Nature Immunology, 2004
Two subsets of dendritic cell (DCs), plasmacytoid (p) and myeloid (m) DCs, have been described in humans and mice. These subsets are known to have divergent roles during an immune response, but their developmental course is unclear. Here we report that virus infection induces bone marrow pDCs to differentiate into mDCs, thereby undergoing profound ...
Elina I, Zuniga, Dorian B, McGavern, Jose L, Pruneda-Paz, Chao, Teng, Michael B A, Oldstone   +4 more
openaire   +2 more sources

The clinical application of cancer immunotherapy based on naturally circulating dendritic cells

Journal for ImmunoTherapy of Cancer, 2019
Dendritic cells (DCs) can initiate and direct adaptive immune responses. This ability is exploitable in DC vaccination strategies, in which DCs are educated ex vivo to present tumor antigens and are administered into the patient with the aim to induce a ...
Kalijn F. Bol, Gerty Schreibelt, Katrin Rabold, Stefanie K. Wculek, Julia Katharina Schwarze, Andrzej Dzionek, Alvaro Teijeira, Lana E. Kandalaft, Pedro Romero, George Coukos, Bart Neyns, David Sancho, Ignacio Melero, I. Jolanda M. de Vries   +13 more
doaj   +1 more source