Results 1 to 10 of about 1,662 (193)

Mitochondrial stress response and myogenic differentiation

Frontiers in Cell and Developmental Biology
Regeneration and repair are prerequisites for maintaining effective function of skeletal muscle under high energy demands, and myogenic differentiation is one of the key steps in the regeneration and repair process. A striking feature of the process of myogenic differentiation is the alteration of mitochondria in number and function.
Fu Lin, Liankun Sun, Yu Zhang, Weinan Gao, Zihan Chen, Zihan Chen, Yanan Liu, Kai Tian, Kai Tian, Xuyu Han, Xuyu Han, Ruize Liu, Ruize Liu, Yang Li, Luyan Shen   +14 more
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miR-9-5p promotes myogenic differentiation via the Dlx3/Myf5 axis [PDF]

PeerJ, 2022
MicroRNAs play an important role in myogenic differentiation, they bind to target genes and regulate muscle formation. We previously found that miR-9-5p, which is related to bone formation, was increased over time during the process of myogenic ...
Liying Dong, Meng Wang, Xiaolei Gao, Xuan Zheng, Yixin Zhang, Liangjie Sun, Na Zhao, Chong Ding, Zeyun Ma, Yixiang Wang   +9 more
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Methyltransferase Dot1L promotes myogenic differentiation of skeletal muscle by regulating promoter methylation level

陆军军医大学学报, 2022
Objective To confirm whether methyltransferase Dot1L is involved in the regulation of myogenic differentiation, and explore its molecular mechanism in the regulation process.
LI Chengcheng, ZHOU Yong, LI Haoke, DENG Zhongliang   +3 more
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Decrotonylation of AKT1 promotes AKT1 phosphorylation and activation during myogenic differentiation

Journal of Advanced Research, 2023
Introduction: Myogenic differentiation plays an important role in pathophysiological processes including muscle injury and regeneration, as well as muscle atrophy. A novel type of posttranslational modification, crotonylation, has been reported to play a
Zhengyu Qian, Jingwei Ye, Jinteng Li, Yunshu Che, Wenhui Yu, Peitao Xu, Jiajie Lin, Feng Ye, Xiaojun Xu, Zepeng Su, Dateng Li, Zhongyu Xie, Yanfeng Wu, Huiyong Shen   +13 more
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Hes6 Regulates Myogenic Differentiation [PDF]

Clinical Science, 2002
Hes6 is a basic helix-loop-helix transcription factor homologous to Drosophila Enhancer of Split (EoS) proteins. It is known to promote neural differentiation and to bind to Hes1, a related protein that is part of the Notch signalling pathway, affecting Hes1-regulated transcription.
Judy, Cossins, Ann E, Vernon, Yun, Zhang, Anna, Philpott, Philip H, Jones   +4 more
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Carbon metabolism–mediated myogenic differentiation [PDF]

Nature Chemical Biology, 2010
The role of nutrients and metabolism in cellular differentiation is poorly understood. Using RNAi screening, metabolic profiling and small-molecule probes, we discovered that the knockdown of three metabolic enzymes-phosphoglycerate kinase (Pgk1), hexose-6-phosphate dehydrogenase (H6pd) and ATP citrate lyase (Acl)-induces differentiation of mouse C2C12
Bracha, Abigail L., Ramanathan, Arvind, Huang, Sui, Ingber, Donald E., Schreiber, Stuart L.   +4 more
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Induction of miR-665-3p Impairs the Differentiation of Myogenic Progenitor Cells by Regulating the TWF1-YAP1 Axis

Cells, 2023
Actin dynamics are known to orchestrate various myogenic processes in progenitor cells. Twinfilin-1 (TWF1) is an actin-depolymerizing factor that plays a crucial role in the differentiation of myogenic progenitor cells. However, little is known about the
Mai Thi Nguyen, Wan Lee
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EV-mediated promotion of myogenic differentiation is dependent on dose, collection medium, and isolation method

Molecular Therapy: Nucleic Acids, 2023
Extracellular vesicles (EVs) have been implicated in the regulation of myogenic differentiation. C2C12 murine myoblast differentiation was reduced following treatment with GW4869 or heparin (to inhibit exosome biogenesis and EV uptake, respectively ...
Britt Hanson, Ioulia Vorobieva, Wenyi Zheng, Mariana Conceição, Yulia Lomonosova, Imre Mäger, Pier Lorenzo Puri, Samir El Andaloussi, Matthew J.A. Wood, Thomas C. Roberts   +9 more
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Modeling Stem Cell Myogenic Differentiation [PDF]

Scientific Reports, 2017
AbstractThe process of stem cell myogenesis (transformation into skeletal muscle cells) includes several stages characterized by the expression of certain combinations of myogenic factors. The first part of this process is accompanied by cell division, while the second part is mainly associated with direct differentiation. The mechanical cues are known
Rajiv S. Deshpande, Alexander A. Spector
openaire   +2 more sources

Stimulation of Non-canonical NF-κB Through Lymphotoxin-β-Receptor Impairs Myogenic Differentiation and Regeneration of Skeletal Muscle

Frontiers in Cell and Developmental Biology, 2021
Myogenic differentiation, muscle stem cell functionality, and regeneration of skeletal muscle are cellular processes under tight control of various signaling pathways.
Manuel Schmidt, Anja Weidemann, Christine Poser, Anne Bigot, Julia von Maltzahn   +4 more
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