Results 11 to 20 of about 1,662 (193)

Confined Sandwichlike Microenvironments Tune Myogenic Differentiation [PDF]

ACS Biomaterials Science & Engineering, 2017
Sandwichlike (SW) cultures are engineered as a multilayer technology to simultaneously stimulate dorsal and ventral cell receptors, seeking to mimic cell adhesion in three-dimensional (3D) environments in a reductionist manner. The effect of this environment on cell differentiation was investigated for several cell types cultured in standard growth ...
Ballester-Beltrán, José, Trujillo, Sara, Alakpa, Enateri V, Compañ, Vicente, Gavara, Rafael, Meek, Dominic, West, Christopher C, Péault, Bruno, Dalby, Matthew J, Salmerón-Sánchez, Manuel   +9 more
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Reductive stress impairs myogenic differentiation

Redox Biology, 2020
Myo-satellite cells regenerate and differentiate into skeletal muscle (SM) after acute or chronic injury. Changes in the redox milieu towards the oxidative arm at the wound site are known to compromise SM regeneration. Recently, we reported that abrogation of Nrf2/antioxidant signaling promotes oxidative stress and impairs SM regeneration in C57/Bl6 ...
Namakkal S. Rajasekaran, Sandeep Balu Shelar, Dean P. Jones, John R. Hoidal   +3 more
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mTORCing about myogenic differentiation [PDF]

Cell Cycle, 2014
The C2C12 myoblast cell line has been extensively studied as it has the potential to differentiate from serum-starved confluent monolayer cultures into myotubes, (Fig. 1, upper panel) which can further align and form muscle fibers. Furthermore, C2C12 myoblasts can differentiate into adipose and bone-type lineages, depending on the conditions present ...
Iadevaia, V, Cowan, JL, Coldwell, MJ
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Notch signaling leads to a slower progression of embryonic myogenic differentiation in Landrace than in Langtang pigs

Acta Biochimica et Biophysica Sinica, 2022
Delving into porcine embryonic myogenesis is the key to elucidate the complex regulation of breed-specific differences in growth performance and meat production.
Cai Shufang, Hu Bin, Zhu Qi, Duo Tianqi, Wang Xiaoyu, Tong Xian, Luo Xiaorong, Yuan Renqiang, Chen Yaosheng, Wang Jing, Luo Chenglong, Xing Baosong, Mo Delin   +12 more
doaj   +1 more source

Factors influencing myogenic differentiation of adipose-derived stem cells and their application in muscle regeneration

Chinese Journal of Plastic and Reconstructive Surgery, 2022
Skeletal muscle regeneration mainly depends on muscle satellite cells; however, these cells are not sufficient for supporting repair and regeneration in volumetric muscle loss (VML), Duchenne muscular dystrophy, and other muscle injuries or muscle ...
Na Liu, Guanhuier Wang, Yonghuan Zhen, Yujia Shang, Fangfei Nie, Lingjuan Zhu, Zhenmin Zhao, Yang An   +7 more
doaj   +1 more source

Ryanodine receptor RyR1-mediated elevation of Ca2+ concentration is required for the late stage of myogenic differentiation and fusion

Journal of Animal Science and Biotechnology, 2022
Background Cytosolic Ca2+ plays vital roles in myogenesis and muscle development. As a major Ca2+ release channel of endoplasmic reticulum (ER), ryanodine receptor 1 (RyR1) key mutations are main causes of severe congenital myopathies.
Kai Qiu, Yubo Wang, Doudou Xu, Linjuan He, Xin Zhang, Enfa Yan, Lu Wang, Jingdong Yin   +7 more
doaj   +1 more source

Myostatin Mutation Enhances Bovine Myogenic Differentiation through PI3K/AKT/mTOR Signalling via Removing DNA Methylation of RACK1

Cells, 2022
Myostatin (MSTN) is a negative regulator of skeletal muscle development and plays an important role in muscle development. Fluctuations in gene expression influenced by DNA methylation are critical for homeostatic responses in muscle.
Yiping Zhao, Xiaoxia Xia, Qiaomeng Wang, Debao Hu, Linlin Zhang, Xin Li, Xiangbin Ding, Hong Guo, Yiwen Guo   +8 more
doaj   +1 more source

Kindlin 2 regulates myogenic related factor myogenin via a canonical Wnt signaling in myogenic differentiation. [PDF]

PLoS ONE, 2013
Kindlin 2, as an integrin-associated protein, is required for myocyte elongation and fusion. However, the association of Kindlin 2 with muscle differentiation-related signaling pathways is unknown. Here, we identified a mechanism that Kindlin 2 regulates
Yu Yu, Lihua Qi, Junzhou Wu, Yunling Wang, Weigang Fang, Hongquan Zhang   +5 more
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Apol9a regulates myogenic differentiation via the ERK1/2 pathway in C2C12 cells

Frontiers in Pharmacology, 2022
Background: The rising prevalence of obesity and its complications is a big challenge for the global public health. Obesity is accompanied by biological dysfunction of skeletal muscle and the development of muscle atrophy.
Xuan Jiang, Xuan Jiang, Siyu Ji, Siyuan Cui, Rong Wang, Rong Wang, Wei Wang, Yongquan Chen, Yongquan Chen, Yongquan Chen, Shenglong Zhu, Shenglong Zhu   +11 more
doaj   +1 more source

JAK-STAT pathway and myogenic differentiation [PDF]

JAK-STAT, 2013
Myogenic differentiation plays an important role in muscle regeneration and is regulated by two transcription factor families, MRFs and MEF2, which induce differentiation of myoblasts through expression of the muscle-specific gene, myogenin. In addition, many intracellular signaling pathways are also involved in myogenic differentiation, including p38 ...
Jang, You-Na, Baik, Eun Joo
openaire   +2 more sources