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Poultry plays an important role in the meat consumer market and is significant to further understanding the potential mechanism of muscle development in the broiler.
Zhen Zhou +7 more
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Directing Myogenic Mesenchymal Stem Cell Differentiation [PDF]
See related article, pages 635–642 Vascular smooth muscle cells (SMCs) play an important role in the embryonic and postnatal development and remodeling of blood vessels. In mature vasculature, SMCs regulate the vascular tone and, thereby, the blood pressure and blood distribution.
Peter E, Westerweel, Marianne C, Verhaar
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RIP2, a Checkpoint in Myogenic Differentiation [PDF]
Using a subtractive cDNA library hybridization approach, we found that receptor interacting protein 2 (RIP2), a tumor necrosis factor receptor 1 (TNFR-1)-associated factor, is a novel early-acting gene that decreases markedly in expression during myogenic differentiation.
Barbara, Munz +3 more
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Myogenic Cell Proliferation and Differentiation
It is generally thought that growth factors play a major role in regulating proliferation and differentiation of myogenic cells. Cell culture studies indicate that of the known growth factors, the fibroblast growth factors, the transforming growth factor beta, and the insulin-like growth factor families play the most significant roles in this process ...
W R, Dayton, M R, Hathaway
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Involvement of cdks and cyclins in muscle differentiation
Myocyte differentiation is due to transcription of genes that characterize the phenotypic and biochemical identity of differentiated muscle cells. These are the myogenic regulatory factors (MRFs) MyoD, Myf5, myogenin and MRF4.
M De Falco, A De Luca
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FTO-mediated demethylation of GADD45B promotes myogenesis through the activation of p38 MAPK pathway
N6-methyladenosine (m6A) modification plays a critical role in mammalian development. However, the role of m6A in the skeletal muscle development remains largely unknown.
Kaiping Deng +10 more
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An initial blueprint for myogenic differentiation [PDF]
We have combined genome-wide transcription factor binding and expression profiling to assemble a regulatory network controlling the myogenic differentiation program in mammalian cells. We identified a cadre of overlapping and distinct targets of the key myogenic regulatory factors (MRFs)—MyoD and myogenin—and Myocyte Enhancer Factor 2 (MEF2).
Alexandre, Blais +5 more
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Gene amplification during myogenic differentiation
Gene amplifications are mostly an attribute of tumor cells and drug resistant cells. Recently, we provided evidence for gene amplifications during differentiation of human and mouse neural progenitor cells. Here, we report gene amplifications in differentiating mouse myoblasts (C2C12 cells) covering a period of 7 days including pre-fusion, fusion and ...
Fischer, Ulrike +4 more
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Myogenic and melanotic differentiated medulloblastoma: case report [PDF]
Medulloblastoma is the most common malignant tumor of childhood and usually arises from the cerebellar vermis. Several histological types of medulloblastoma have been described. Myogenic and melanotic differentiated medulloblastoma are seldom seen. We present a case diagnosed as myogenic medulloblastoma with focal areas of melanotic differentiation.
Kurt, Gokhan +4 more
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p38 mitogen-activated protein kinase (MAPK) is an essential kinase involved in myogenic differentiation. Although many substrates of p38 MAPK have been identified, little is known about its upstream activators during myogenic differentiation.
Fang Xiao +4 more
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