Results 41 to 50 of about 1,662 (193)

Covalent CDK7 Inhibitor THZ1 Inhibits Myogenic Differentiation [PDF]

Journal of Cancer, 2018
Covalent CDK7 inhibitor THZ1 is a newly discovered anti-tumor drug.THZ1 affects the function of transcription factor TFIIH by inhibiting CDK7, which in turn affects RNA polymerase II, and ultimately affects transcription initiation. Study found that THZ1 could inhibit proliferation and promote apoptosis of several tumor cell lines. However, there is no
Ma, Xinqi, Kuang, Xielan, Xia, Qing, Huang, Zixin, Fan, Yuting, Ning, Jie, Wen, Jiajie, Zhang, Han, Yan, Jianhua, Zhang, Qingjiong, Shen, Huangxuan, Long, Chongde   +11 more
openaire   +2 more sources

SMAD2 Promotes Myogenin Expression and Terminal Myogenic Differentiation [PDF]

Development, 2020
ABSTRACTSMAD2 is a transcription factor whose activity is regulated by members of the Transforming Growth Factor beta (TGFβ) superfamily. While activation of SMAD2 and SMAD3 downstream of TGFβ or myostatin signaling is known to inhibit myogenesis, we find that SMAD2 in the absence of TGFβ signaling promotes terminal myogenic differentiation.
Émilie Lamarche, Hamood AlSudais, Rashida Rajgara, Dechen Fu, Saadeddine Omaiche, Nadine Wiper-Bergeron   +5 more
openaire   +3 more sources

The Effect of Heat Shock on Myogenic Differentiation of Human Skeletal-Muscle-Derived Mesenchymal Stem/Stromal Cells

Cells, 2022
Muscle injuries, degenerative diseases and other lesions negatively affect functioning of human skeletomuscular system and thus quality of life. Therefore, the investigation of molecular mechanisms, stimulating myogenic differentiation of primary ...
Rokas Mikšiūnas, Siegfried Labeit, Daiva Bironaitė   +2 more
doaj   +1 more source

Zeb2 Regulates Myogenic Differentiation in Pluripotent Stem Cells [PDF]

International Journal of Molecular Sciences, 2020
Skeletal muscle differentiation is triggered by a unique family of myogenic basic helix-loop-helix transcription factors, including MyoD, MRF-4, Myf-5, and Myogenin. These transcription factors bind promoters and distant regulatory regions, including E-box elements, of genes whose expression is restricted to muscle cells.
Ester Sara Di Filippo, Domiziana Costamagna, Giorgia Giacomazzi, Álvaro Cortés-Calabuig, Agata Stryjewska, Danny Huylebroeck, Stefania Fulle, Maurilio Sampaolesi   +7 more
openaire   +3 more sources

Thioredoxin mitigates H2O2‐induced inhibition of myogenic differentiation of rat bone marrow mesenchymal stem cells by enhancing AKT activation

FEBS Open Bio, 2020
Thioredoxin (Trx) is a hydrogen acceptor of ribonucleotide reductase and a regulator of some enzymes and receptors. It has been previously shown that significantly elevated levels of Trx expression are associated with the osteogenic differentiation of ...
Meiling Liu, Xianglu Li, Changlin Zhou, Manfeng Wang, Hongzhi Wang, Haifeng Ding, Luyang Cheng, Lu Gan, Xiaowei Wu, Zhimin Du   +9 more
doaj   +1 more source

Geranylgeraniol-induced Myogenic Differentiation of C2C12 Cells [PDF]

In Vivo, 2018
Geranylgeraniol (GGOH) is a C20 isoprenoid found in fruits, vegetables, and grains, including rice. As a food substance, GGOH is categorized as 'Generally Recognized as Safe'. GGOH is an intermediate product in the mevalonate pathway and acts as a precursor to geranylgeranyl pyrophosphate.C2C12 mouse myoblasts derived from muscle satellite cells were ...
Takuma, Matsubara, Mariko, Urata, Tsuyoshi, Nakajima, Mari, Fukuzaki, Ryo, Masuda, Yoshiyuki, Yoshimoto, William N, Addison, Chihiro, Nakatomi, Kazmasa, Morikawa, Min, Zhang, Katsura, Saeki, Yukiko, Takahashi, Atsuko, Nakamichi, Shoichiro, Kokabu   +13 more
openaire   +2 more sources

The matricellular protein ADAMTS-like 2 regulates differentiation of skeletal muscle-resident fibro-adipogenic progenitor cells

iScience
Summary: Skeletal muscle development and regeneration requires the activities of myogenic and non-myogenic muscle stem cell populations. Non-myogenic muscle stem cells, such as fibro-adipogenic progenitors (FAPs), play important roles in muscle ...
Charlene Redhead, Nandaraj Taye, Britney Chin-Young, Kasoorelope Oguntuyo, James H. Cummins, Kevin J. Hart, Woojin M. Han, Dirk Hubmacher   +7 more
doaj   +1 more source

Decrease in the expression of muscle-specific miRNAs, miR-133a and miR-1, in myoblasts with replicative senescence.

PLoS ONE, 2023
Muscles that are injured or atrophied by aging undergo myogenic regeneration. Although myoblasts play a pivotal role in myogenic regeneration, their function is impaired with aging. MicroRNAs (miRNAs) are also involved in myogenic regeneration.
Kaori Shintani-Ishida, Riko Tsurumi, Hiroshi Ikegaya   +2 more
doaj   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Schwann Cells Promote Myogenic Differentiation of Myoblasts and Adipogenic Mesenchymal Stromal Cells on Poly-ɛ-Caprolactone-Collagen I-Nanofibers

Cells, 2022
For the purpose of skeletal muscle tissue engineering, different cell types have been investigated regarding their myogenic differentiation potential, including co-cultured myoblasts and adipogenic mesenchymal stromal cells (Mb/ADSC).
Aijia Cai, Zeng-Ming Zheng, Marcus Himmler, Dirk W. Schubert, Thomas A. Fuchsluger, Volker Weisbach, Raymund E. Horch, Andreas Arkudas   +7 more
doaj   +1 more source