Results 21 to 30 of about 2,964 (225)

Role of enzymatic activity in muscle damage and cytotoxicity induced by Bothrops asper Asp49 phospholipase A2 myotoxins: are there additional effector mechanisms involved? [PDF]

PeerJ, 2014
Viperid venoms often contain mixtures of Asp49 and Lys49 PLA2 myotoxin isoforms, relevant to development of myonecrosis. Given their difference in catalytic activity, mechanistic studies on each type require highly purified samples.
Diana Mora-Obando, Cecilia Díaz, Yamileth Angulo, José María Gutiérrez, Bruno Lomonte   +4 more
doaj   +3 more sources

The many dimeric faces of Lys49 PLA₂-like proteins: Conformational plasticity and membrane binding drive functional dimer states. [PDF]

Protein Sci
Abstract Lys49 secreted phospholipase A2‐like proteins (sPLA2s) are major myotoxins in viperid snake venoms, causing rapid muscle damage in envenomation. Beyond their clinical relevance, these small non‐catalytic proteins provide a model to study how quaternary structure and conformational dynamics enable catalysis‐independent membrane disruption ...
Lima DCA, Dos Santos VF, Rassi B, Ward RJ, Soares TA.   +4 more
europepmc   +2 more sources

Serum Proteinogram in the Free-Living Brazilian Common Opossum (Didelphis aurita). [PDF]

Electrophoresis
ABSTRACT Didelphis aurita is a synanthropic marsupial widely distributed in southeastern Brazil, known for its resistance to venom and its relevance in biomedical research. This study aimed to characterize the serum proteinogram of free‐living D. aurita individuals.
Orozco AMO, Bento LD, Souto PC, Girardi FM, Castro VR, Oliveira JVG, Lopez CJR, Barros E, Campos AK, Fonseca LAD.   +9 more
europepmc   +2 more sources

Structure-based design of an antibacterial peptide from the Myotoxin II sequence, evaluating its effectiveness against Gram-negative bacteria and its safety [PDF]

Scientific Reports
Bacterial resistance poses a significant public health challenge, particularly for pathogens prioritized by the World Health Organization, such as carbapenem-resistant Escherichia coli.
Tatiana Huertas, Diana Millán, Angela V. Fonseca-Benítez, James Guevara-Pulido   +3 more
doaj   +2 more sources

Snake venom defensins: Defining the structural and functional characteristics of the toxin family [PDF]

Journal of Structural Biology: X
Snake venom defensins are a toxin family found in rattlesnake venoms (Crotalus) which are comprised of crotamine-like peptides and myotoxins. Their tertiary structure resembles the β-defensin family structure.
David Melendez-Martinez, Adriana Morales-Martinez, Iliana Vanessa Almanza-Campos, Francisco Sierra-Valdez, Miguel Borja, Alejandro Carbajal-Saucedo, Christopher L. Parkinson, Jorge Benavides   +7 more
doaj   +2 more sources

Anti-inflammatory activity of Blutaparon portulacoides ethanolic extract against the inflammatory reaction induced by Bothrops jararacussu venom and isolated myotoxins BthTX-I and II [PDF]

, 2009
This article reports the anti-inflammatory effect of Blutaparon portulacoides (B. portulacoides), specifically the ethanolic extract of its aerial parts, on the edema formation and leukocyte influx caused by Bothrops jararacussu (B.
BARBOSA, AM, COGO, JC, PEREIRA, IC, RIBEIRO, W, SALVADOR, MJ, SOARES, AM, ZAMUNER, SR   +6 more
core   +4 more sources

Efficacy of Mitochondrial Transfer in Healing Toxin-Induced Damage to Neuromuscular Junction, an Empirical Study. [PDF]

Synapse
A neuromuscular junction (NMJ) imaged with pre‐ and postsynaptic features seen with immunofluorescent staining along with confocal microscopy. The article presented here confirms the importance of regaining proper posttraumatic NMJ structure to enable reestablishment of healthy skeletal muscle mass and how the presence of mitochondrial matter promotes ...
Deschenes MR, Rackley M, Fernandez S, Heidebrecht M, Hamilton K, Paez HG, Paez CR, Alway SE.   +7 more
europepmc   +2 more sources

Effects of Bothrops asper snake venom on lymphatic vessels: insights into a hidden aspect of envenomation. [PDF]

PLoS Neglected Tropical Diseases, 2008
Envenomations by the snake Bothrops asper represent a serious medical problem in Central America and parts of South America. These envenomations concur with drastic local tissue pathology, including a prominent edema. Since lymph flow plays a role in the
Javier Mora, Rodrigo Mora, Bruno Lomonte, José María Gutiérrez   +3 more
doaj   +7 more sources

Neutralization of the neuromuscular activity of bothropstoxin-i, a myotoxin from Bothrops jararacussu snake venom, by a hydroalcoholic extract of Casearia sylvestris Sw. (guaçatonga) [PDF]

Journal of Venomous Animals and Toxins including Tropical Diseases, 2005
Numerous plants are used as snakebite antidotes in Brazilian folk medicine, including Casearia sylvestris Swartz, popularly known as guaçatonga. In this study, we examined the action of a hydroalcoholic extract from C.
Y. Oshima-Franco, C. M. V. Alves, N. Andréo Filho, M. Gerenutti, A. C. O. Cintra, G. B. Leite, L. Rodrigues-Simioni, M. G. Silva   +7 more
doaj   +3 more sources

Calcium ion independent membrane leakage induced by phospholipase-like myotoxins

Biochemistry, 1992
The two snake venom myotoxins ammodytin L and myotoxin II, purified respectively from Vipera ammodytes ammodytes and Bothrops asper, have phospholipase-like structures but lack an Asp-49 in the active site and are without normal phospholipase activity. The interaction of these proteins with different types of liposomes indicated that the myotoxins were
RUFINI, STEFANO, Cesaroni, P, DESIDERI, ALESSANDRO, Farias, R, Gubensek, F, Gutiérrez, J, LULY, PAOLO, MASSOUD, RENATO, Morero, R, PEDERSEN, JENS ZACHO   +9 more
openaire   +7 more sources