Results 11 to 20 of about 4,874 (195)

N-Glycolylneuraminic Acid (Neu5Gc) Null Large Animals by Targeting the CMP-Neu5Gc Hydroxylase (CMAH) [PDF]

Frontiers in Immunology, 2019
The two major sialic acids described in mammalian cells are the N-glycolylneuraminic acid (Neu5Gc) and the N-acetylneuraminic acid (Neu5Ac). Neu5Gc synthesis starts from the N-acetylneuraminic acid (Neu5Ac) precursor modified by an hydroxylic group ...
Andrea Perota, Cesare Galli, Cesare Galli   +2 more
doaj   +5 more sources

Preferential Accumulation of 14C-N-Glycolylneuraminic Acid over 14C-N-Acetylneuraminic Acid in the Rat Brain after Tail Vein Injection. [PDF]

PLoS ONE, 2015
The two main molecular species of sialic acid existing in nature are N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc). Neu5Ac is abundant in mammalian brains and plays crucial roles in many neural functions.
Risa Taguchi, Akira Minami, Yukino Matsuda, Tadanobu Takahashi, Tadamune Otsubo, Kiyoshi Ikeda, Takashi Suzuki   +6 more
doaj   +2 more sources

Understanding the Effects of Lactose Hydrolysis Modeling on the Main Oligosaccharides in Goat Milk Whey Permeate [PDF]

Molecules, 2019
Enzymatic hydrolysis of lactose is a crucial step to improve the efficiency and selectivity of membrane-based separations toward the recovery of milk oligosaccharides free from simple sugars.
Caroline Thum, Valerie Weinborn, Daniela Barile, Warren C McNabb, Nicole C Roy, Juliana Maria Leite Nobrega de Moura Bell   +5 more
doaj   +4 more sources

Species-specific N-glycan patterns in animal and human breast milk samples [PDF]

Frontiers in Nutrition
The main components of milk are protein, fat and carbohydrates. Glycans are complex carbohydrate structures covalently bound to proteins and lipids or exist freely in solutions.
Davide Ret, Davide Ret, Salvatore Alessio Gentile, Johanna Rohrhofer, Larissa Koidl, Francesca Cozzi, Eva Untersmayr   +6 more
doaj   +2 more sources

Replication of H9 influenza viruses in the human ex vivo respiratory tract, and the influence of neuraminidase on virus release [PDF]

Scientific Reports, 2017
H9N2 viruses are the most widespread influenza viruses in poultry in Asia. We evaluated the infection and tropism of human and avian H9 influenza virus in the human respiratory tract using ex vivo respiratory organ culture.
Renee W. Y. Chan, Louisa L. Y. Chan, Chris K. P. Mok, Jimmy Lai, Kin P. Tao, Adebimpe Obadan, Michael C. W. Chan, Daniel R. Perez, J. S. Malik Peiris, John M. Nicholls   +9 more
doaj   +2 more sources

Variability of Sialic Acids in Beef Breeds and Nutritional Implications in Red Meat [PDF]

Molecules
This study examines the variability of sialic acids, specifically N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc), in beef from seven cattle breeds (Holstein Friesian, Red Pied, Maremmana, Chianina, Charolais, Limousin, and ...
Michela Contò, Maria Miarelli, Sabrina Di Giovanni, Sebastiana Failla   +3 more
doaj   +2 more sources

A comparative study of N-glycolylneuraminic acid (Neu5Gc) and cytotoxic T cell (CT) carbohydrate expression in normal and dystrophin-deficient dog and human skeletal muscle. [PDF]

PLoS ONE, 2014
The expression of N-glycolylneuraminic acid (Neu5Gc) and the cytotoxic T cell (CT) carbohydrate can impact the severity of muscular dystrophy arising from the loss of dystrophin in mdx mice.
Paul T Martin, Bethannie Golden, Jonathan Okerblom, Marybeth Camboni, Kumaran Chandrasekharan, Rui Xu, Ajit Varki, Kevin M Flanigan, Joe N Kornegay   +8 more
doaj   +2 more sources

Generation of cattle knockout for galactose-α1,3-galactose and N-glycolylneuraminic acid antigens. [PDF]

Xenotransplantation, 2019
AbstractTwo well‐characterized carbohydrate epitopes are absent in humans but present in other mammals. These are galactose‐α1,3‐galactose (αGal) and N‐glycolylneuraminic acid (Neu5Gc) which are introduced by the activities of two enzymes including α(1,3) galactosyltransferase (encoded by the GGTA1 gene) and CMP‐Neu5Gc hydroxylase (encoded by the CMAH ...
Perota A, Lagutina I, Duchi R, Zanfrini E, Lazzari G, Judor JP, Conchon S, Bach JM, Bottio T, Gerosa G, Costa C, Galiñanes M, Roussel JC, Padler-Karavani V, Cozzi E, Soulillou JP, Galli C.   +16 more
europepmc   +8 more sources

Why Is N-Glycolylneuraminic Acid Rare in the Vertebrate Brain? [PDF]

Top Curr Chem, 2015
The sialic acids N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc) differ by a single oxygen atom and are widely found at the terminal position of glycans on vertebrate cell surfaces. In animals capable of synthesizing Neu5Gc, most tissues and cell types express both sialic acids, in proportions that vary between species. However,
Davies LR, Varki A.
europepmc   +4 more sources

Comparison of sialic acid content in bovine and buffalo milk and meat

Revista Científica, 2023
Animal-origin food, such as meat and milk, are important sources of sialic acids (SIAs) with relevant implications for human health. Two significant SIAs in mammals are N-acetyl-neuraminic acid (Neu5Ac) and N- glycolylneuraminic acid (Neu-5Gc).
Michela Contò, Simona Rinaldi, Sebastiana Failla   +2 more
doaj   +1 more source