Biochemical and Biophysical Research Communications, 2018 N-glycolylneuraminic acid (Neu5Gc)-containing glycans are a prominent form of aberrant glycosylation found in human tumor cells and have been proposed as cancer biomarkers. The B subunit of the subtilase cytotoxin (SubB) produced by Shiga toxigenic Escherichia coli recognises Neu5Gc containing glycans. We have previously engineered this lectin, SubB2M,
L.K. Shewell +5 more
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Pathogens, 2023 Porcine meat is the most consumed red meat worldwide. Pigs are also vital tools in biological and medical research. However, xenoreactivity between porcine’s N-glycolylneuraminic acid (Neu5Gc) and human anti-Neu5Gc antibodies poses a significant ...
Oluwamayowa Joshua Ogun +2 more
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A comparison of three methods of decellularization of pig corneas to reduce immunogenicity. [PDF]
, 2014 AIM: To investigate whether decellularization using different techniques can reduce immunogenicity of the cornea, and to explore the decellularized cornea as a scaffold for cultured corneal endothelial cells (CECs).
Cooper, David KC +4 more
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Canine and feline parvoviruses preferentially recognize the non-human cell surface sialic acid N-glycolylneuraminic acid. [PDF]
Virology, 2013 Feline panleukopenia virus (FPV) is a pathogen whose canine-adapted form (canine parvovirus (CPV)) emerged in 1978. These viruses infect by binding host transferrin receptor type-1 (TfR), but also hemagglutinate erythrocytes. We show that hemagglutination involves selective recognition of the non-human sialic acid N-glycolylneuraminic acid (Neu5Gc) but
Löfling J, Lyi SM, Parrish CR, Varki A.
europepmc +3 more sources
Proinflammatory Mechanism of N-Glycolylneuraminic Acid in Mice through Regulating the Gut Microbiota [PDF]
Shipin KexueIn this study, the effect of 18 weeks of dietary supplementation of porcine submaxillary gland mucin (PSM) as an abundant source of N-hydroxyacetylneuraminic acid (Neu5Gc) on the expression of proteins involved in the nuclear factor kappa-B (NF-κB ...
HE Leli, LIU Chuxin, XIAO Yi, SHEN Qingwu, WU Yanyang
doaj +1 more source
Evaluation of human and non-human primate antibody binding to pig cells lacking GGTA1/CMAH/β4GalNT2 genes [PDF]
, 2015 Background Simultaneous inactivation of pig GGTA1 and CMAH genes eliminates carbohydrate xenoantigens recognized by human antibodies. The β4GalNT2 glycosyltransferase may also synthesize xenoantigens.
Adams, A.B. +9 more
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Expression of NeuGc on Pig Corneas and Its Potential Significance in Pig Corneal Xenotransplantation [PDF]
, 2016 PURPOSE: Pigs expressing neither galactose-α1,3-galactose (Gal) nor N-glycolylneuraminic acid (NeuGc) take xenotransplantation one step closer to the clinic. Our aims were (1) to document the lack of NeuGc expression on corneas and aortas and cultured
Ayares, David +10 more
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N-glycolylneuraminic acid and N-acetylneuraminic acid define feline blood group A and B antigens [PDF]
Blood, 1992 Abstract Blood group incompatibility causes transfusion reactions and neonatal isoerythrolysis in cats. We investigated the molecular nature of the blood group antigens from cats that had blood type A, B, and AB erythrocytes. Naturally occurring anti-type B antibodies, Triticum vulgaris lectin, monoclonal antibody (MoAb) 32–27, and MoAb ...
G A, Andrews +3 more
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TRYPANOSOMA-CRUZI TRANS-SIALIDASE and NEURAMINIDASE ACTIVITIES CAN BE MEDIATED BY the SAME ENZYMES [PDF]
, 1992 Trans-sialidase and neuraminidase activities have been detected on the surface membrane of trypomastigotes of Trypanosoma cruzi, and both have been implicated in the parasite's invasion of host cells.
Decarvalho, L. P. +2 more
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Porcine to Human Heart Transplantation: Is Clinical Application Now Appropriate? [PDF]
, 2017 Cardiac xenotransplantation (CXTx) is a promising solution to the chronic shortage of donor hearts. Recent advancements in immune suppression have greatly improved the survival of heterotopic CXTx, now extended beyond 2 years, and life-supporting kidney ...
Byrne, GW, McGregor, CGA
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