Results 71 to 80 of about 4,874 (195)

Genetic Divergence and Antibody Expression Influence the N‐Glycomes of CHO‐K1 and CHO‐S Cells

Biotechnology and Bioengineering, Volume 122, Issue 11, Page 3160-3175, November 2025.
ABSTRACT While Chinese hamster ovary (CHO) cells continue to be the workhorse of recombinant therapeutic protein production, decades of genetic divergence in the industrially relevant CHO‐K1 and CHO‐S cell lines, are likely to have resulted in differing glycosylation capabilities. Glycosylation can influence the efficacy, serum half‐life, and safety of
Roberto Donini, Pat Blundell, Richard J. Pleass, Dongli Lu, Anne Dell, Cleo Kontoravdi, Stuart M. Haslam   +6 more
wiley   +1 more source

Structure of a Sialo-Oligosaccharide from Glycophorin in Carp Red Blood Cell Membranes

Membranes, 2014
We isolated a high-purity carp glycophorin from carp erythrocyte membranes and prepared the oligosaccharide fraction from glycophorin by β-elimination [1].
Takahiko Aoki, Kenji Chimura, Hikaru Sugiura, Yasuko Mizuno   +3 more
doaj   +1 more source

Acupuncture for Major Depressive Disorder: Exploring the Gut Microbiota as a Novel Therapeutic Pathway

Brain and Behavior, Volume 15, Issue 11, November 2025.
Acupuncture at GV20 and ST36 alleviates depression by modulating gut microbiota, increasing beneficial bacteria, and enhancing neuroactive metabolites like Sphinganine 1‐phosphate, thereby restoring neuronal activity and reducing depressive behaviors. ABSTRACT Aims This study investigates the efficacy of acupuncture at Baihui (GV20) and Zusanli (ST36 ...
Cailing Wei, Yijun Li, Jiarong Tian, Pu Lei, Yuanyuan Ding, Wen Lu, Xiaoyan He, Ya'ni Yang, Hao Zhu, Ruina Liu   +9 more
wiley   +1 more source

Isolation and Characterization of Glycophorin from Carp Red Blood Cell Membranes

Membranes, 2014
We isolated a high-purity carp glycophorin from carp erythrocyte membranes following extraction using the lithium diiodosalicylate (LIS)-phenol method and streptomycin treatment.
Takahiko Aoki, Kenji Chimura, Nobuhiro Nakao, Yasuko Mizuno   +3 more
doaj   +1 more source

Transposable element insertions have strongly affected human evolution [PDF]

, 2010
Comparison of a full collection of the transposable element (TE) sequences of vertebrates with genome sequences shows that the human genome makes 655 perfect full-length matches.
Britten, Roy J.
core   +2 more sources

Potential Effects of Three Forms of Sialic Acid on Intestinal Health in Obese Mice Fed With a High‐Fat Diet

Food Frontiers, Volume 6, Issue 6, Page 3090-3107, November 2025.
A high‐fat diet impairs intestinal health by disrupting the mucus layer, widening epithelial gaps, triggering inflammation, and causing microbial dysbiosis, ultimately leading to obesity and metabolic disorders. Sialic acid interventionsparticularly bound forms (3ʹ‐SL and EBN)outperform free Neu5Ac in restoring microbial balance, alleviating ...
Xinyue Wang, Wei Zhang, Xinyuan Huang, Linlin Zhou, Xinning Zhao, Hanying Zheng, Xudan Shen, Xinyi Wang, Lili Pan, Yahui Li, Hongwei Li   +10 more
wiley   +1 more source

Immunobiological barriers to xenotransplantation [PDF]

, 2015
Binding of natural anti-pig antibodies in humans and nonhuman primates to carbohydrate antigens expressed on the transplanted pig organ, the most important of which is galactose-α1,3-galactose (Gal), activate the complement cascade, which results in ...
Cooper, David K. C., Ekser, Burcin, Tector, A. Joseph   +2 more
core   +1 more source

Revolutionizing Heart Valve Therapy: A Translational Framework for Combining Decellularized Scaffolds With Genetic Modification

Journal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 113, Issue 11, November 2025.
ABSTRACT Valvular heart disease (VHD) represents a significant global health challenge, affecting over 2.5% of the population and disproportionately impacting older adults due to age‐related degenerative processes. Current treatment options—mechanical and bioprosthetic valves—both present substantial limitations that impact patient quality of life and ...
Nikolaos P. Tzavellas, Natalia Atzemoglou, Efstathios L. Pavlidis, Alkinoos Nikolis, Georgios S. Markopoulos, Konstantinos I. Tsamis, Dimitrios Peschos, Yannis V. Simos, Lampros Lakkas   +8 more
wiley   +1 more source

Straightforward access to 2,3- and 3,4-unsaturated derivatives of N-glycolylneuraminic acid

Tetrahedron, 2020
Abstract The facile syntheses of previously unreported 2,3- and 3,4-unsaturated derivatives of N-glycolylneuraminic acid are herein described. The procedure involves a ring-opening of the 4,5-oxazoline of N-acetylneuraminic acid, the acylation of the intermediate free amine, its conversion into the 4,5-oxazoline of N-glycolylneuraminic acid and the ...
P. Rota, P. La Rocca, V. Franco, P. Allevi   +3 more
openaire   +2 more sources

Streptococcus pneumoniae NanC. Structural insights into the specificity and mechanism of a sialidase that produces a sialidase inhibitor [PDF]

, 2015
This work was supported by the Biotechnology and Biological Sciences Research Council (UK) and the Medical Research Council (UK).Streptococcus pneumoniae is an important human pathogen that causes a range of disease states.
Lukacik, Petra, Owen, C. David, Potter, Jane A., Sleator, Olivia, Taylor, Garry L., Walsh, Martin A.   +5 more
core   +1 more source