Results 121 to 130 of about 3,551 (133)
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Cancer Research, 2023
Abstract Background: N1-methyladenosine (m1A) within tRNAs, an essential and highly conserved RNA modification, has recently emerged as a significant epigenetic modification that plays a pivotal role in tumor progression in some cancers. However, the role of m1A methylation in colorectal cancer (CRC) remains largely unexplored.
SILEI SUI +4 more
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Abstract Background: N1-methyladenosine (m1A) within tRNAs, an essential and highly conserved RNA modification, has recently emerged as a significant epigenetic modification that plays a pivotal role in tumor progression in some cancers. However, the role of m1A methylation in colorectal cancer (CRC) remains largely unexplored.
SILEI SUI +4 more
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N1-methyladenosine methylome in messenger RNA and non-coding RNA
Current Opinion in Chemical Biology, 2018Chemical modifications to rRNA, tRNA and mRNA provide a new regulatory layer of gene expression, which is termed as the `epitranscriptome'. N1-methyladenosine (m1A), first characterized more than 50 years ago, is a well-known modification in rRNA and tRNA.
Xushen, Xiong, Xiaoyu, Li, Chengqi, Yi
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Sensors and Actuators B: Chemical, 2022
Abstract Specific and accurate determination of N1-Methyladenosine (m1A) is of critical significance to better understand its biological functions. Precise quantification of low level of RNA modification against a high background of homologous normal RNA still remains a big challenge.
Yuanyuan Sun +3 more
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Abstract Specific and accurate determination of N1-Methyladenosine (m1A) is of critical significance to better understand its biological functions. Precise quantification of low level of RNA modification against a high background of homologous normal RNA still remains a big challenge.
Yuanyuan Sun +3 more
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Small Molecule‐Inducible and Photoactivatable Cellular RNA N1‐Methyladenosine Editing
Angewandte ChemieAbstractN1‐methyladenosine (m1A) modification is one of the most prevalent epigenetic modifications on RNA. Given the vital role of m1A modification in RNA processing such as splicing, stability and translation, developing a precise and controllable m1A editing tool is pivotal for in‐depth investigating the biological functions of m1A.
Guoyou Xie +12 more
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The Secret Life of N1-methyladenosine: A Review on its Regulatory Functions
Journal of Molecular BiologyN1-methyladenosine (m1A) is a conserved modification on house-keeping RNAs, including tRNAs and rRNAs. With recent advancement on m1A detection and mapping, m1A is revealed to have a secret life with regulatory functions. This includes the regulation of its canonical substrate tRNAs, and expands into new territories such as tRNA fragments, mRNAs and ...
Nhi Yen Tran, Nguyen +3 more
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ACS Chemical Biology
tRNA modifications help maintain tRNA structure and facilitate translation and stress response. Found in all three kingdoms of life, m1A tRNA modification occurs in the T loop of many tRNAs, stabilizes tertiary tRNA structure, and impacts translation.
Marcus Foo +6 more
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tRNA modifications help maintain tRNA structure and facilitate translation and stress response. Found in all three kingdoms of life, m1A tRNA modification occurs in the T loop of many tRNAs, stabilizes tertiary tRNA structure, and impacts translation.
Marcus Foo +6 more
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Methods
With the recent advanced direct RNA sequencing technique that proposed by the Oxford Nanopore Technologies, RNA modifications can be detected and profiled in a simple and straightforward manner. Majority nanopore-based modification studies were devoted to those popular types such as m6A and pseudouridine.
Shenglun, Chen, Jia, Meng, Yuxin, Zhang
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With the recent advanced direct RNA sequencing technique that proposed by the Oxford Nanopore Technologies, RNA modifications can be detected and profiled in a simple and straightforward manner. Majority nanopore-based modification studies were devoted to those popular types such as m6A and pseudouridine.
Shenglun, Chen, Jia, Meng, Yuxin, Zhang
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Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie, 1981
We describe the selective analysis of N-methylated ribonucleosides, i.e., N1-methyl adenosine (m1Ado) and N7-methyl guanosine (m7Guo) in the presence of other nucleosides in urine. m1Ado as well as m7Guo were characterized by use of chromatographic techniques including substance specific chemical reactions.
E, Schlimme, K S, Boos, M, Weise
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We describe the selective analysis of N-methylated ribonucleosides, i.e., N1-methyl adenosine (m1Ado) and N7-methyl guanosine (m7Guo) in the presence of other nucleosides in urine. m1Ado as well as m7Guo were characterized by use of chromatographic techniques including substance specific chemical reactions.
E, Schlimme, K S, Boos, M, Weise
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Method for isolation of 2′-O-methylribonucleosides and N1-methyladenosine from ribonucleic acid
Biochimica et Biophysica Acta, 1963Abstract N1-methyladenosine and the 2′-O-methyl derivatives of adenosine, uridine, guanosine, and cytidine have been isolated from yeast soluble RNA. A nucleoside mixture obtained by enzymic hydrolysis of the RNA was resolved by means of chromatography on partition columns into major fractions.
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Demethylase-assisted site-specific detection of N1-methyladenosine in RNA
Chinese Chemical LettersJun Xiong +8 more
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