Results 31 to 40 of about 213,525 (212)

Development of the Cerebrospinal Fluid in Early Stage after Hemorrhage in the Central Nervous System

Life, 2021
Extravasation of blood in the central nervous system (CNS) represents a very strong damaged associated molecular patterns (DAMP) which is followed by rapid inflammation and can participate in worse outcome of patients.
Petr Kelbich, Aleš Hejčl, Jan Krejsek, Tomáš Radovnický, Inka Matuchová, Jan Lodin, Jan Špička, Martin Sameš, Jan Procházka, Eva Hanuljaková, Petr Vachata   +10 more
doaj   +1 more source

Gut Microbiota in Primary Sarcopenia: Mechanisms and Potential Therapeutic Targets

Frontiers in Bioscience-Landmark
As the global population ages, the risks associated with primary sarcopenia, including falls, fractures, functional decline, and frailty, are becoming increasingly apparent, all of which significantly impair the quality of life in older adults.
Leshan Chen, Youming Chen, Wenzhan Chen, Huiting Tan, Liuyan Ye, Jinsong Chen, Xuejuan Xu   +6 more
doaj   +1 more source

Assays for NAD+-Dependent Reactions and NAD+ Metabolites [PDF]

, 2018
Nicotinamide adenine dinucleotide (NAD+) is an essential redox cofactor and signaling molecule that controls the activity of enzymes involved in metabolism, DNA repair, and cellular survival, such as the PARPs, CD38, and the sirtuins. Here, we describe three methods for measuring the activity of these enzymes: the etheno-NAD+ assay measures NAD ...
Michael B, Schultz, Yuancheng, Lu, Nady, Braidy, David A, Sinclair   +3 more
openaire   +2 more sources

Extracellular vesicles circulating in young organisms promote healthy longevity

Journal of Extracellular Vesicles, 2019
Parabiosis experiments in mice demonstrated that a young environment could partially rejuvenate multiple tissues of old organisms. However, the circulating mediators responsible of such effect have been elusive so far.
Francesco Prattichizzo, Angelica Giuliani, Jacopo Sabbatinelli, Emanuela Mensà, Valeria De Nigris, Lucia La Sala, Paola de Candia, Fabiola Olivieri, Antonio Ceriello   +8 more
doaj   +1 more source

Structural modeling of NAD+ binding modes to PARP-1

Вавиловский журнал генетики и селекции, 2017
The nuclear protein poly (ADP-ribose) polymerase-1 (PARP-1) plays an important role in the signaling and repair of DNA. PARP-1 catalyses covalent binding of poly (ADP-ribose) polymers with itself as well as with other acceptor proteins using NAD+ as a ...
N. V. Ivanisenko, D. A. Zhechev, V. A. Ivanisenko   +2 more
doaj   +1 more source

Historical Agricultural Landforms—Central European Bio-Cultural Heritage Worthy of Attention

Land, 2022
Knowledge about past agricultural land management can bring solutions for future needs. One undervalued historical type of historical rural landscape in temperate Europe is termed plužiny.
Johana Zacharová, Jiří Riezner, Jitka Elznicová, Iva Machová, Karel Kubát, Diana Holcová, Michal Holec, Jan Pacina, Jiří Štojdl, Tomáš Matys Grygar   +9 more
doaj   +1 more source

NAD replenishment restores mitochondrial function and thermogenesis in the brown adipose tissue of mice with obesity

The Journal of Physiology, EarlyView.
Abstract figure legend A high‐fat diet (HFD) induces brown adipose tissue (BAT) whitening, mitochondrial dysfunction (damaged cristae, fragmentation), reduced NAD+ levels and impaired thermogenesis, leading to lower energy expenditure and metabolic inflexibility.
Renata R. Braga, Matheus B. Rocha, Ana P. Morelli, Raul G. da Costa, Marcelo A. S. Mori, Adelino S. R. da Silva, José R. Pauli, Dennys E. Cintra, Eduardo R. Ropelle   +8 more
wiley   +1 more source

Single bolus injection of nicotinamide mono nucleotide increases systemic insulin sensitivity in association with activation of NAD salvage pathway in the liver and adipose tissue in mice

Endocrine Journal
Rising nicotinamide adenine dinucleotide (NAD+) levels mitigate the onset and progression of age-related diseases including metabolic disorders.
Shunsuke Hiroshige, Yasuko Kajimura, Yuko Nagao, Akihiko Taguchi, Ryoko Hatanaka, Chika Yodokawa, Yuka Fujioka, Masaru Akiyama, Yukio Tanizawa, Yasuharu Ohta   +9 more
doaj   +1 more source

Information and Material Support to Environmental Education in Slovakia in the Times of Crisis

Acta Educationis Generalis, 2023
Introduction: The undergoing globalization brings epidemiological, economical, energetical, and environmental security risks. The current task in the field of improving the quality of the environment is educating students in schools for adaptation to the
Bilčík Alexander, Bilčíková Jana, Lajčin Daniel, Barnová Silvia   +3 more
doaj   +1 more source

Timing of NAD Deficiency During Organogenesis Dictates Defect Type and Penetrance

The FASEB Journal, Volume 40, Issue 3, 15 February 2026.
Pregnant mice on a vitamin B3‐free and tryptophan‐limited diet have embryos with Congenital NAD Deficiency Disorder, characterized by malformations and/or death. We longitudinally tracked the maternal NAD metabolome, embryo growth, and malformation occurrence. Mice with lower NAD Salvage Pathway metabolite levels and minimal levels of derived excretion
Kayleigh Bozon, Hartmut Cuny, Nana Sunn, Ella M. M. A. Martin, Delicia Z. Sheng, Gavin Chapman, Sally L. Dunwoodie   +6 more
wiley   +1 more source