Results 111 to 120 of about 19,910 (273)
Non-invasive assessment of murine PD-L1 levels in syngeneic tumor models by nuclear imaging with nanobody tracers [PDF]
, 2017 Blockade of the inhibitory PD-1/PD-L1 immune checkpoint axis is a promising cancer treatment. Nonetheless, a significant number of patients and malignancies do not respond to this therapy.
Breckpot, K +9 more
core +2 more sources
Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases
BMEMat, EarlyView.This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou +6 more
wiley +1 more source
CellsThe immunofluorescence assay is widely used for cellular biology and diagnosis applications. Such an antigen–antibody detection system enables the assessment and visualization of the expression and localization of target proteins.
Wenjie Sheng +10 more
doaj +1 more source
An Affinity-directed PROtein Missile (AdPROM) system for targeted proteolysis [PDF]
, 2016 The von Hippel-Lindau (VHL) protein serves to recruit the hypoxia inducible factor alpha (HIF1α) protein under normoxia to the CUL2 E3 ubiquitin ligase for its ubiquitylation and degradation through the proteasome.
Bozatzi, Polyxeni +5 more
core +3 more sources
Fluorescent Diarylethenes With Polar Groups: Synthesis, Spectra, and Optical Microscopy Applications
Chemistry – A European Journal, EarlyView.Blinking green and flashing red: photo‐switchable and photo‐activatable probes emitting green and red light were prepared and applied as bioconjugates in super‐resolution optical microscopy. ABSTRACT The use of photoactivatable fluorescent diarylethenes (fDAEs) in biology‐related light microscopy has been restricted by the lack of probes having freely ...
Kakishi Uno +6 more
wiley +1 more source
A small protein probe for correlated microscopy of endogenous proteins [PDF]
, 2018 Probes are essential to visualize proteins in their cellular environment, both using light microscopy as well as electron microscopy (EM). Correlated light microscopy and electron microscopy (CLEM) requires probes that can be imaged simultaneously by ...
de Beer, Marit A +3 more
core +2 more sources
Chemistry – A European Journal, EarlyView.The introduction outlines the review scope. Microbial cell factories as living drugs cover host–gut microbiota, bacteria, yeast, and other microbial systems, with comparative host advantages. Engineering strategies include synthetic circuits, quorum sensing, and memory.
Cemile Elif Özçelik +3 more
wiley +1 more source
VNARs: An Ancient and Unique Repertoire of Molecules That Deliver Small, Soluble, Stable and High Affinity Binders of Proteins [PDF]
, 2015 Peer reviewedPublisher ...
Clem +4 more
core +3 more sources
The Canadian Journal of Chemical Engineering, EarlyView.Schematic representation of artificial intelligence approaches in enzyme catalysis, integrating bibliometric analysis, emerging research trends, and machine learning tools for enzyme design, prediction, and industrial biocatalytic applications. Abstract This study systematically explores the applications of artificial intelligence (AI) in enzyme ...
Misael Bessa Sales +6 more
wiley +1 more source
Nanoscopic compartmentalization of membrane protein motion at the axon initial segment [PDF]
, 2016 The axon initial segment (AIS) is enriched in specific adaptor, cytoskeletal, and transmembrane molecules. During AIS establishment, a membrane diffusion barrier is formed between the axonal and somatodendritic domains.
Albrecht, D +5 more
core +1 more source