Results 131 to 140 of about 11,503 (243)

Seventh Åland Island Meeting on von Willebrand Disease

Haemophilia, EarlyView.
ABSTRACT Introduction The seventh Åland Island Meeting on von Willebrand Disease (VWD) was held on the Åland archipelago in Finland, from 26 to 28 September 2024. Aim The meeting brought together experts in the field of VWD from around the world to share the latest advances and knowledge in VWD.
Riitta Lassila, Ruben Bierings, Nathan T. Connell, Fernando F. Corrales‐Medina, Augusto B. Federici, Veronica H. Flood, Floor Heubel‐Moenen, Jill M. Johnsen, Geoffrey Kuppens, Davide Matino, Carolyn Millar, Ingmar Schoen, Anish Sharda, Robert F. Sidonio Jr, Alok Srivastava, Timea Szanto, Angela C. Weyand, Erik Berntorp   +17 more
wiley   +1 more source

Nanobodies targeting the Epstein-Barr virus EBNA1 DNA binding domain inhibit tumor growth. [PDF]

J Nanobiotechnology
Wu F, Wu Y, Han Y, Ma L, Huang Y, Peng C, Liu J, Gao P, Xu W.   +8 more
europepmc   +1 more source

Mapping of C5‐Blocking Monoclonal Antibodies Reveals New C5 Inhibitory Epitopes and Novel Modes of C5 Inhibition

Immunology, EarlyView.
We identify four distinct C5 inhibitory epitopes, including two novel antibodies that selectively block membrane attack complex (MAC) assembly while preserving C5 cleavage and C5a generation. These findings establish selective MAC inhibition as a new therapeutic strategy for complement‐mediated diseases.
Rebekah Sian Cooke, Kok Yung Lee, Georgina Elizabeth Menzies, Masashi Mizuno, Bryan Paul Morgan, Wioleta Milena Zelek   +5 more
wiley   +1 more source

A nanobody against CD63 for non-destructive exosome labeling. [PDF]

Biol Direct
Chen S, Wang F, Chen C, Cheng Y, Chen M, Li Z, Tang X.   +6 more
europepmc   +1 more source

Bacteriophage P22 Virus‐Like Particles as Nanoscale Protein Scaffolds for Plant Synthetic Biology

Plant Biotechnology Journal, EarlyView.
ABSTRACT Advancing the utility of plant synthetic biology requires the continued development of protein engineering tools. Self‐assembling protein compartments, such as virus‐like particles (VLPs), provide versatile scaffolds for synthetic biology. However, few plant‐expressed VLPs have demonstrated broad amenability to protein engineering, restricting
Maxim D. Harding, Mark A. Jackson, Edward K. Gilding, David J. Craik, Frank Sainsbury, Nicole Lawrence   +5 more
wiley   +1 more source

Nanobodies unlock new mechanisms to target G protein-coupled receptors. [PDF]

Mol Pharmacol
Skiba MA.
europepmc   +1 more source

Harnessing Natural Diversity and Rational Design for Enhanced Plant Immunity

Plant, Cell &Environment, EarlyView.
ABSTRACT Plant pathogens cause crop loss. Genetic resistance, through natural genetic diversity or engineered resistance, can be highly effective in protecting plants from infection. Genetic resistance from wild relatives of crops has been successfully introduced into crops to control pathogen infection.
Nathan Diplock, Jennifer D. Lewis
wiley   +1 more source

Computational nanobody design using graph neural networks and Metropolis Monte Carlo sampling. [PDF]

Brief Bioinform
Wang L, He X, Qian X, Guo G, Huang Q.
europepmc   +1 more source

Role of RIPK1/RIPK3/MLKL signalling pathway in sepsis‐associated acute kidney injury

Experimental Physiology, EarlyView.
Abstract Sepsis‐associated acute kidney injury (SA‐AKI) is a common clinical syndrome in critically ill patients, and its high mortality rate is closely related to complex pathological mechanisms. Existing studies have shown that the pathophysiological process of SA‐AKI involves complex multi‐mechanism interactions, including an uncontrolled systemic ...
Huijun Yin, Jingyi Wang, Huirong Han
wiley   +1 more source

Conformation-sensitive nanobody immunoassay enables differentiation of live and heat-inactivated Salmonella Typhimurium for food safety monitoring. [PDF]

Food Chem
Pan J, He Q, Xu Z, Zhang Y, Li W, Chen J, Hu L, Shi X, Hammock BD, Li D.   +9 more
europepmc   +1 more source