Results 211 to 220 of about 14,448 (252)
TR-FRET between engineered nanobodies reveals the existence of endogenous CXCR4 oligomers. [PDF]
Commun BiolHeuninck J +17 more
europepmc +1 more source
Exploiting Nanobodies’ Singular Traits
Annual Review of Immunology, 2018 The unique class of heavy chain–only antibodies, present in Camelidae, can be shrunk to just the variable region of the heavy chain to yield VHHs, also called nanobodies. About one-tenth the size of their full-size counterparts, nanobodies can serve in applications similar to those for conventional antibodies, but they come with a number of signature ...
Jessica R Ingram +2 more
exaly +4 more sources
Seminars in Immunology, 2021 For treatment and diagnosis of cancer, antibodies have proven their value and now serve as a first line of therapy for certain cancers. A unique class of antibody fragments called nanobodies, derived from camelid heavy chain-only antibodies, are gaining increasing acceptance as diagnostic tools and are considered also as building blocks for chimeric ...
Andrew W Woodham, Hidde L Ploegh
exaly +4 more sources
Nanobodies as novel agents for disease diagnosis and therapy
International Journal of Nanomedicine, 2013 Christina G Siontorou Department of Industrial Management and Technology, University of Piraeus, Piraeus, Greece Abstract: The discovery of naturally occurring, heavy-chain only antibodies in Camelidae, and their further development into small ...
Christina G Siontorou
exaly +1 more source
Radiolabeling Strategies of Nanobodies for Imaging Applications
Diagnostics, 2021 Nanobodies are small recombinant antigen-binding fragments derived from camelid heavy-chain only antibodies. Due to their compact structure, pharmacokinetics of nanobodies are favorable compared to full-size antibodies, allowing rapid accumulation to ...
Jim Kuppers +2 more
exaly +2 more sources
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Annual Review of Animal Biosciences, 2021
Unique, functional, homodimeric heavy chain–only antibodies, devoid of light chains, are circulating in the blood of Camelidae. These antibodies recognize their cognate antigen via one single domain, known as VHH or Nanobody. This serendipitous discovery made three decades ago has stimulated a growing number of researchers to generate highly specific ...
openaire +2 more sources
Unique, functional, homodimeric heavy chain–only antibodies, devoid of light chains, are circulating in the blood of Camelidae. These antibodies recognize their cognate antigen via one single domain, known as VHH or Nanobody. This serendipitous discovery made three decades ago has stimulated a growing number of researchers to generate highly specific ...
openaire +2 more sources